Human-Specific RNA Metabolism: Mechanisms, Dysregulation, and Disease Implications
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 245
Special Issue Editor
2. Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL 33701, USA
Interests: lncRNA; cardiometabolic diseases; human genetics
Special Issue Information
Dear Colleagues,
RNA metabolism includes the transcription, splicing, modification, transportation, translation, and degradation of RNA molecules. As almost all key elements involved in RNA metabolism, including promoters, splicing signals, and untranslated regions of mRNA, are poorly conserved among different species, our knowledge of animal models cannot be easily applied to humans. Meanwhile, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), which are largely non-conserved, are emerging as crucial regulators of many fundamental biological processes; dysregulation of these non-coding RNAs contributes to human diseases ranging from cardiometabolic defects to cancer. The recent discovery that mRNA also undergoes extensive methylation modulated by distinct protein regulators, including “writers”, “erasers”, and “readers”, reveals another layer of RNA metabolism affecting human pathophysiology. Given the significance of RNA metabolism and its lack of conservation across species, we urgently need to improve our understanding of human-specific RNA metabolism, from its mechanisms and dysregulation to disease implications. We welcome submissions of original research articles or comprehensive reviews relating to human-specific RNA metabolism for this Special Issue.
Dr. Xiangbo Ruan
Guest Editor
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Keywords
- human-specific RNA metabolism
- mechanisms
- dysregulation
- disease implications
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