Oxidant Stress in Liver Diseases
A special issue of Livers (ISSN 2673-4389).
Deadline for manuscript submissions: closed (12 February 2024) | Viewed by 11083
Special Issue Editors
Interests: drug-induced liver injury; acetaminophen; acute liver failure; hepatic ischemia-reperfusion injury; obstructive cholestasis
Special Issues, Collections and Topics in MDPI journals
Interests: drug induced liver injury; acute liver failure; innate immune response; mitochondrial dysfunction; oxidative and nitrosative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidant stress is a commonly invoked cause of cell death in many acute and chronic liver diseases, including liver injury caused by alcohol, drugs, and other xenobiotics; cholestasis; alcoholic and non-alcoholic steatohepatitis; acute inflammation; fibrosis; and even cancer. This Special Issue will cover all aspects of oxidant stress as a cause of cell death, as well as the identification of the sources and specific species of reactive oxygen and reactive nitrogen during various liver pathophysiologies. This also includes investigations into the modulation of endogenous defense mechanisms against oxidant stress. Although oxidant stress has been implicated in all liver diseases, there is a lack of clinically approved therapeutic interventions that specifically target reactive oxygen and reactive nitrogen species. The main reason for the limited translation of the preclinical data is the lack of a detailed mechanistic understanding of these events beyond correlative studies in relevant disease models and in patients. This Special Issue invites original contributions and expert reviews to close this gap in knowledge which can lay the foundation for identifying therapeutic targets and intervention strategies against oxidant stress that can have clinical relevance.
Prof. Dr. Hartmut W. Jaeschke
Dr. Anup Ramachandran
Dr. Mitchell R. McGill
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Livers is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ferroptosis
- lipid peroxidation
- iron
- desferoxamine
- antioxidants
- inflammation
- drug hepatotoxicity
- hepatic ischemia–reperfusion injury
- mitochondria
- glutathione
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