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Marine Drugs
Special Issues
Marine Anti-Biofilm Compounds from Natural to Synthetic Compounds
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Marine Anti-Biofilm Compounds from Natural to Synthetic Compounds

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 6920

Special Issue Editors

Dr. Marie-Lise Bourguet-Kondracki

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Guest Editor
Molécules de Communication et Adaptation des Microorganismes, UMR 7245 CNRS, Muséum National d’Histoire Naturelle, 57 rue Cuvier (CP54), 75005 Paris, France
Interests: marine natural product chemistry; marine sponges; marine microbiology; marine chemical ecology; bioactivity; antifouling, anti-biofilm compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Jean Michel Brunel

E-Mail Website
Guest Editor
UMR_MD1, Faculté de Pharmacie, Aix-Marseille Universite, 27 Bd Jean Moulin, CEDEX 5, 13385 Marseille, France
Interests: antimicrobial agents; antibiotic enhancers; organic chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Melissa M. Cadelis

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Guest Editor
School of Medical Sciences, University of Auckland, Auckland 1142, New Zealand
Interests: natural product; medicinal chemistry; organic chemistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Brent R. Copp

E-Mail Website
Guest Editor
School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand
Interests: marine natural product; medicinal chemistry; organic chemistry

Special Issue Information

Dear Colleagues,

Biofilms are characterized as complex communities of microorganisms (bacteria, fungi, yeasts, algae, protozoa and viruses) that can adhere to any surface and interact with each other and their environment. They play an important role in bacterial resistance. As there is an urgent need for new antibiotics, alternative strategies to combat bacterial resistance are being actively sought. Anti-biofilm agents, which can act at different stages of biofilm formation, have emerged as a promising avenue. The exploration of the marine world, which is a unique source of promising new bioactive compounds, could be crucial to overcoming this serious global public health crisis. 

Therefore, any discovery of new or synthetic compounds with antibiofilm/antibiotic or antifouling activity or with activity related to the quorum sensing, EPS matrix and genes involved in formation and adhesion are highly welcome for this vast Special Issue. The potential multiple applications in medicine, industry and aquatic environment are other aspects of this topic that can also be explored and presented in this issue.

Dr. Marie-Lise Bourguet-Kondracki
Dr. Jean Michel Brunel
Dr. Melissa M. Cadelis
Prof. Dr. Brent R. Copp
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural or synthetic products
  • antibiofilm
  • antimicrobial
  • antibiotics
  • antifouling
  • quorum sensing
  • EPS matrix

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Published Papers (3 papers)

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Research

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18 pages, 5059 KiB  
Article
Batzelladine D, a Marine Natural Product, Reverses the Fluconazole Resistance Phenotype Mediated by Transmembrane Transporters in Candida albicans and Interferes with Its Biofilm: An In Vitro and In Silico Study
by Levy T. S. Domingos, Daniel C. de Moraes, Mário F. C. Santos, José A. R. Curvelo, Brayan Bayona-Pacheco, Edgar A. Marquez, Anthony W. B. Martinez, Roberto G. S. Berlinck and Antonio Ferreira-Pereira
Mar. Drugs 2024, 22(11), 502; https://doi.org/10.3390/md22110502 - 5 Nov 2024
Viewed by 651
Abstract
Numerous Candida species are responsible for fungal infections; however, Candida albicans stands out among the others. Treatment with fluconazole is often ineffective due to the resistance phenotype mediated by transmembrane transporters and/or biofilm formation, mechanisms of resistance commonly found in C. albicans strains. [...] Read more.
Numerous Candida species are responsible for fungal infections; however, Candida albicans stands out among the others. Treatment with fluconazole is often ineffective due to the resistance phenotype mediated by transmembrane transporters and/or biofilm formation, mechanisms of resistance commonly found in C. albicans strains. A previous study by our group demonstrated that batzelladine D can inhibit the Pdr5p transporter in Saccharomyces cerevisiae. In the present study, our aim was to investigate the efficacy of batzelladine D in inhibiting the main efflux pumps of Candida albicans, CaCdr1p and CaCdr2p, as well as to evaluate the effect of the compound on C. albicans biofilm. Assays were conducted using a clinical isolate of Candida albicans expressing both transporters. Additionally, to allow the study of each transporter, S. cerevisiae mutant strains overexpressing CaCdr1p or CaCdr2p were used. Batzelladine D was able to reverse the fluconazole resistance phenotype by acting on both transporters. The compound synergistically improved the effect of fluconazole against the clinical isolate when tested in the Caenorhabditis elegans animal model. Moreover, the compound disrupted the preformed biofilm. Based on the obtained data, the continuation of batzelladine D studies as a potential new antifungal agent and/or chemosensitizer in Candida albicans infections can be suggested. Full article
(This article belongs to the Special Issue Marine Anti-Biofilm Compounds from Natural to Synthetic Compounds)
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Review

Jump to: Research

22 pages, 2518 KiB  
Review
Anti-Biofilm Extracts and Molecules from the Marine Environment
by Flore Caudal, Catherine Roullier, Sophie Rodrigues, Alain Dufour, Sébastien Artigaud, Gwenaelle Le Blay, Alexis Bazire and Sylvain Petek
Mar. Drugs 2024, 22(7), 313; https://doi.org/10.3390/md22070313 - 10 Jul 2024
Cited by 1 | Viewed by 4486
Abstract
Pathogenic bacteria and their biofilms are involved in many diseases and represent a major public health problem, including the development of antibiotic resistance. These biofilms are known to cause chronic infections for which conventional antibiotic treatments are often ineffective. The search for new [...] Read more.
Pathogenic bacteria and their biofilms are involved in many diseases and represent a major public health problem, including the development of antibiotic resistance. These biofilms are known to cause chronic infections for which conventional antibiotic treatments are often ineffective. The search for new molecules and innovative solutions to combat these pathogens and their biofilms has therefore become an urgent need. The use of molecules with anti-biofilm activity would be a potential solution to these problems. The marine world is rich in micro- and macro-organisms capable of producing secondary metabolites with original skeletons. An interest in the chemical strategies used by some of these organisms to regulate and/or protect themselves against pathogenic bacteria and their biofilms could lead to the development of bioinspired, eco-responsible solutions. Through this original review, we listed and sorted the various molecules and extracts from marine organisms that have been described in the literature as having strictly anti-biofilm activity, without bactericidal activity. Full article
(This article belongs to the Special Issue Marine Anti-Biofilm Compounds from Natural to Synthetic Compounds)
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26 pages, 1555 KiB  
Review
Proof of Concept of Natural and Synthetic Antifouling Agents in Coatings
by Daniela Pereira, Joana R. Almeida, Honorina Cidade and Marta Correia-da-Silva
Mar. Drugs 2024, 22(7), 291; https://doi.org/10.3390/md22070291 - 24 Jun 2024
Cited by 1 | Viewed by 1267
Abstract
Marine biofouling, caused by the deposition and accumulation of marine organisms on submerged surfaces, represents a huge concern for the maritime industries and also contributes to environmental pollution and health concerns. The most effective way to prevent this phenomenon is the use of [...] Read more.
Marine biofouling, caused by the deposition and accumulation of marine organisms on submerged surfaces, represents a huge concern for the maritime industries and also contributes to environmental pollution and health concerns. The most effective way to prevent this phenomenon is the use of biocide-based coatings which have proven to cause serious damage to marine ecosystems. Several research groups have focused on the search for new environmentally friendly antifoulants, including marine and terrestrial natural products and synthetic analogues. Some of these compounds have been incorporated into marine coatings and display interesting antifouling activities caused by the interference with the biofilm-forming species as well as by the inhibition of the settlement of macroorganisms. This review highlights the proof-of-concept studies of emerging natural or synthetic antifouling compounds in coatings, from lab-made to commercial ones, performed between 2019 and 2023 and their results in the field or in in vivo laboratorial tests. Full article
(This article belongs to the Special Issue Marine Anti-Biofilm Compounds from Natural to Synthetic Compounds)
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