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Marine Drugs
Special Issues
Marine Drugs Research in Spain 2nd Edition
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Marine Drugs Research in Spain 2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 8234

Special Issue Editors

Dr. Fernando Reyes

E-Mail Website
Guest Editor
Fundación MEDINA, Avda del Conocimiento 34, Parque Tecnológico Ciencias Salud, E-18016 Granada, Spain
Interests: chromatography; mass spectrometry; liquid chromatography; natural product chemistry; nuclear magnetic resonance; bioactivity; medicinal chemistry; NMR structure elucidation; LC-MS/MS; MIC; compound isolation; structure elucidation; natural products; metabolite identification; alkaloids; pharmacognosy; bioassays; HPLC-UV; bioactive secondary metabolites; marine natural products
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jaime Rodríguez

E-Mail Website
Guest Editor
Centro de Investigacións Científicas Avanzadas (CICA) e Departamento de Química, Facultade de Ciencias, Universidade de A Coruña, 15071 A Coruña, Spain
Interests: organic structure elucidation; stereochemistry and configurational analysis by NMR and computational methods; organic synthesis of natural products; siderophores; pathogenic bacteria in aquaculture
Special Issues, Collections and Topics in MDPI journals
Dr. Javier Fernández

E-Mail Website
Guest Editor
Instituto Universitario de Bio-Orgáncia Antonio González (IUBOAG), Universidad de la Laguna (ULL), 38206 San Cristobal de La Laguna, Spain
Interests: marine natural products; marine toxins; marine polyether; marine microalgae; biosynthesis; Laurencia; antiparasitic substances; phosphatase inhibitors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Spain is outlined by nearly 8000 km of coastline, which makes it one of the most important countries to study the chemistry and the biology of marine life. The first marine natural product reports from Spain date back to the early 1970s, with publications on marine organisms collected in the Atlantic Ocean authored by one of the pioneers of marine natural products in Spain, the late Prof. Antonio Gonzalez from the University of La Laguna in the Canary Islands. These publications constituted the seed for the study of marine organisms and their natural products by some other research groups, including the universities of Cadiz, Salamanca, Santiago de Compostela, and CSIC.

Following the success of the first Special Issue on “Marine Drugs Research in Spain”, which was composed of more than 10 published papers, we will continue paying tribute to these marine research schools with this second edition, providing Spanish researchers and institutions with a platform for publishing biomedical and chemical studies on substances of marine origin. We welcome papers focused on the isolation, structure elucidation and synthesis of marine compounds, metabolomics of marine extracts, biosynthetic aspects of marine metabolites and/or any other biological aspects of marine macro- or microorganism research.

Dr. Fernando Reyes
Prof. Dr. Jaime Rodríguez
Dr. Javier Fernández
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • structure elucidation
  • isolation
  • synthesis
  • metabolomics
  • biosynthesis
  • bioactive compounds

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Published Papers (4 papers)

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Research

19 pages, 1553 KiB  
Article
Chitosan-Based Oleogels: Emulsion Drying Kinetics and Physical, Rheological, and Textural Characteristics of Olive Oil Oleogels
by Mario Lama, Leticia Montes, Daniel Franco, Amaya Franco-Uría and Ramón Moreira
Mar. Drugs 2024, 22(7), 318; https://doi.org/10.3390/md22070318 - 17 Jul 2024
Viewed by 1000
Abstract
Oleogels are of high interest as promising substitutes for trans fats in foods. An emulsion-templated method was used to trap olive oil in the chitosan crosslinked with vanillin matrix. Oil in water emulsions (50:50 w/w) with different chitosan content (0.7 [...] Read more.
Oleogels are of high interest as promising substitutes for trans fats in foods. An emulsion-templated method was used to trap olive oil in the chitosan crosslinked with vanillin matrix. Oil in water emulsions (50:50 w/w) with different chitosan content (0.7 and 0.8% w/w) with a constant vanillin/chitosan ratio (1.3) were air-dried at different temperatures (50, 60, 70, and 80 °C) and freeze-dried (−26 °C and 0.1 mbar) to produce oleogels. Only falling rate periods were determined during air-drying kinetics and were successfully modeled with empirical and diffusional models. At a drying temperature of 70 °C, the drying kinetics were the fastest. The viscoelasticity of oleogels showed that the elastic modulus significantly increased after drying at 60 and 70 °C, and those dried at 50 °C and freeze-dried were weaker. All oleogels showed high oil binding capacity (>91%), but the highest values (>97%) were obtained in oleogels with a threshold elastic modulus (50,000 Pa). The oleogels’ color depended on the drying temperature and chitosan content (independent of the drying method). Significant differences were observed between air-dried and freeze-dried oleogels with respect to oxidative stability. Oxidation increased with the air-drying time regardless of chitosan content. The found results indicated that drying conditions must be carefully selected to produce oleogels with specific features. Full article
(This article belongs to the Special Issue Marine Drugs Research in Spain 2nd Edition)
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16 pages, 2818 KiB  
Article
Synthetic Antimicrobial Peptides Fail to Induce Leucocyte Innate Immune Functions but Elicit Opposing Transcriptomic Profiles in European Sea Bass and Gilthead Seabream
by Laura Cervera, Elena Chaves-Pozo and Alberto Cuesta
Mar. Drugs 2024, 22(2), 86; https://doi.org/10.3390/md22020086 - 14 Feb 2024
Cited by 1 | Viewed by 1845
Abstract
Antimicrobial peptides (AMPs) are promising molecules in diverse fields, including aquaculture. AMPs possess lytic effects on a wide range of pathogens, resulting in a potential replacement for traditional antimicrobials in aquaculture. In addition, they also have modulatory effects on host immune responses. Thus, [...] Read more.
Antimicrobial peptides (AMPs) are promising molecules in diverse fields, including aquaculture. AMPs possess lytic effects on a wide range of pathogens, resulting in a potential replacement for traditional antimicrobials in aquaculture. In addition, they also have modulatory effects on host immune responses. Thus, the objective of this work was to evaluate the immunomodulatory capability of three known synthetic AMPs derived from European sea bass, NK-lysin (Nkl), hepcidin (Hamp), and dicentracin (Dic), in head-kidney cell suspensions from European sea bass and gilthead seabream. The tested peptides were neither cytotoxic for European sea bass nor gilthead seabream cells and failed to modulate the respiratory burst and phagocytosis activities. However, they modified the pattern of transcription of immune-related genes differently in both species. Peptides were able to promote the expression of marker genes for anti-inflammatory (il10), antiviral (mx, irf3), cell-mediated cytotoxicity (nccrp1, gzmb), and antibody responses (ighm) in European sea bass, with the Nkl peptide being the most effective. Contrary to this, the effects of those peptides on gilthead seabream mainly resulted in the suppression of immune responses. To conclude, European sea bass-derived peptides can be postulated as potential tools for immunostimulation in European sea bass fish farms, but more efforts are required for their universal use in other species. Full article
(This article belongs to the Special Issue Marine Drugs Research in Spain 2nd Edition)
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15 pages, 2539 KiB  
Article
New Eremophilane-Type Sesquiterpenes from the Marine Sediment-Derived Fungus Emericellopsis maritima BC17 and Their Cytotoxic and Antimicrobial Activities
by Jorge R. Virués-Segovia, Carlos Millán, Cristina Pinedo, Victoria E. González-Rodríguez, Sokratis Papaspyrou, David Zorrilla, Thomas A. Mackenzie, María C. Ramos, Mercedes de la Cruz, Josefina Aleu and Rosa Durán-Patrón
Mar. Drugs 2023, 21(12), 634; https://doi.org/10.3390/md21120634 - 11 Dec 2023
Cited by 4 | Viewed by 3124
Abstract
The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima. On the basis of the one strain–many compounds (OSMAC) approach, four new eremophilane-type sesquiterpenes (1–4 [...] Read more.
The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima. On the basis of the one strain–many compounds (OSMAC) approach, four new eremophilane-type sesquiterpenes (1–4), together with thirteen known derivatives (5–17) and two reported diketopiperazines (18, 19), were isolated from this strain. The chemical structures and absolute configurations of the new compounds were determined through extensive NMR and HRESIMS spectroscopic studies and ECD calculation. Thirteen of the isolated eremophilanes were examined for cytotoxic and antimicrobial activities. PR toxin (16) exhibited cytotoxic activity against HepG2, MCF-7, A549, A2058, and Mia PaCa-2 human cancer cell lines with IC50 values ranging from 3.75 to 33.44 µM. (+)-Aristolochene (10) exhibited selective activity against the fungal strains Aspergillus fumigatus ATCC46645 and Candida albicans ATCC64124 at 471 µM. Full article
(This article belongs to the Special Issue Marine Drugs Research in Spain 2nd Edition)
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19 pages, 1869 KiB  
Article
Rugulopteryx-Derived Spatane, Secospatane, Prenylcubebane and Prenylkelsoane Diterpenoids as Inhibitors of Nitric Oxide Production
by Belén Cuevas, Ana I. Arroba, Carolina de los Reyes and Eva Zubía
Mar. Drugs 2023, 21(4), 252; https://doi.org/10.3390/md21040252 - 19 Apr 2023
Cited by 5 | Viewed by 1693
Abstract
This study aimed to evaluate the anti-inflammatory potential of the different classes of diterpenoids produced by algae of the genus Rugulopteryx. First, sixteen diterpenoids (1–16), including spatane, secospatane, prenylcubebane, and prenylkelsoane metabolites, were isolated from the extract of [...] Read more.
This study aimed to evaluate the anti-inflammatory potential of the different classes of diterpenoids produced by algae of the genus Rugulopteryx. First, sixteen diterpenoids (1–16), including spatane, secospatane, prenylcubebane, and prenylkelsoane metabolites, were isolated from the extract of the alga Rugulopteryx okamurae collected at the southwestern Spanish coasts. Eight of the isolated diterpenoids are new compounds whose structures were determined by spectroscopic means: the spatanes okaspatols A-D (1–4); the secospatane rugukamural D (8); the prenylcubebanes okacubols A (13) and B (14); and okamurol A (16), which exhibits an unusual diterpenoid skeleton featuring a kelsoane-type tricyclic nucleus. Second, anti-inflammatory assays were performed on microglial cells Bv.2 and macrophage cells RAW 264.7. Compounds 1, 3, 6, 12, and 16 caused significant inhibition of the NO overproduction induced by LPS in Bv.2 cells, and compounds 3, 5, 12, 14, and 16 significantly decreased levels of NO in LPS-stimulated RAW 264.7 cells. The most active compound was okaspatol C (3), which completely suppressed the effects of LPS stimulation, both in Bv.2 and in RAW 264.7 cells. Full article
(This article belongs to the Special Issue Marine Drugs Research in Spain 2nd Edition)
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