Climate Change and Marine Natural Products

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 5005

Special Issue Editors


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Guest Editor
Department of Drug Discovery, Medical University of South Carolina, Charleston, SC 29425, USA
Interests: marine natural products chemistry; infectious diseases; cancer; spectroscopy; drug discovery and development
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA
Interests: natural products; medicinal plants; GI microbiome

Special Issue Information

Dear Colleagues,

Since the 1950s, a growing number of secondary metabolites have been characterized from marine invertebrates, plants, algae, and microbes, which has provided a vast array of structural diversity and potential drug leads. However, the diversity of the oceans and coral reef communities in general is challenged like no other as a product of climate change. At the same time, climate change is having a growing influence in the emergence of a variety of human health issues. Of course, the recent Nobel Prizes awarded to William Campbell, Satoshi Omura, and Tu Youyou for their pioneering work in the development of treatments for roundworm parasites and malaria emphasize the significance of natural product discoveries in the control of emerging diseases.

In this Special Issue of Marine Drugs, we are encouraging investigators to provide preliminary communications, expert opinions, research papers, and reviews covering the impact that climate change is having and will have on the future of emerging diseases, marine species diversity, drug discovery, and human health. In this compilation of papers, we will also assess the impact climate change is having on the marine environment, human health, and our ability of react with new chemical entities from the oceans. We would also encourage contributions that assess climate change and the impact climate change is having on both marine biodiversity as well as the global prevalence of emerging diseases.

Prof. Mark Hamann
Dr. Xiaoyan Chen
Guest Editors

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Keywords

  • marine therapeutics and species diversity
  • climate change and its impact on the oceans
  • tropical neglected diseases
  • drug discovery and development
  • natural products synthesis
  • methodologies in natural products discovery
  • climate change and emerging diseases

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Published Papers (1 paper)

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Research

22 pages, 1911 KiB  
Article
Comparative Analysis of the Soluble Proteome and the Cytolytic Activity of Unbleached and Bleached Millepora complanata (“Fire Coral”) from the Mexican Caribbean
by Víctor Hugo Hernández-Elizárraga, Norma Olguín-López, Rosalina Hernández-Matehuala, Andrea Ocharán-Mercado, Andrés Cruz-Hernández, Ramón Gerardo Guevara-González, Juan Caballero-Pérez, César Ibarra-Alvarado, Judith Sánchez-Rodríguez and Alejandra Rojas-Molina
Mar. Drugs 2019, 17(7), 393; https://doi.org/10.3390/md17070393 - 3 Jul 2019
Cited by 8 | Viewed by 4532
Abstract
Coral bleaching caused by global warming has resulted in massive damage to coral reefs worldwide. Studies addressing the consequences of elevated temperature have focused on organisms of the class Anthozoa, and up to now, there is little information regarding the mechanisms by which [...] Read more.
Coral bleaching caused by global warming has resulted in massive damage to coral reefs worldwide. Studies addressing the consequences of elevated temperature have focused on organisms of the class Anthozoa, and up to now, there is little information regarding the mechanisms by which reef forming Hydrozoans face thermal stress. In this study, we carried out a comparative analysis of the soluble proteome and the cytolytic activity of unbleached and bleached Millepora complanata (“fire coral”) that inhabited reef colonies exposed to the 2015–2016 El Niño-Southern Oscillation in the Mexican Caribbean. A differential proteomic response involving proteins implicated in key cellular processes, such as glycolysis, DNA repair, stress response, calcium homeostasis, exocytosis, and cytoskeleton organization was found in bleached hydrocorals. Four of the proteins, whose levels increased in bleached specimens, displayed sequence similarity to a phospholipase A2, an astacin-like metalloprotease, and two pore forming toxins. However, a protein, which displayed sequence similarity to a calcium-independent phospholipase A2, showed lower levels in bleached cnidarians. Accordingly, the hemolytic effect of the soluble proteome of bleached hydrocorals was significantly higher, whereas the phospholipase A2 activity was significantly reduced. Our results suggest that bleached M. complanata is capable of increasing its toxins production in order to balance the lack of nutrients supplied by its symbionts. Full article
(This article belongs to the Special Issue Climate Change and Marine Natural Products)
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