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Marine Drugs
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20 Years Commemorative Issue in Honor of Professor Paul J....
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20 Years Commemorative Issue in Honor of Professor Paul J. Scheuer

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 7209

Special Issue Editors

Prof. Dr. Bill J. Baker

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Guest Editor
Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE 205, Tampa, FL 33620-5250, USA
Interests: biodiscovery; cold-water chemistry; infectious disease drug discovery; marine invertebrates, fungi, algae; chemical ecology; biosynthesis; genome mining
Prof. Dr. Mark T. Hamann

E-Mail Website
Guest Editor
Department of Drug Discovery, Medical University of South Carolina, Charleston, SC 29425, USA
Interests: marine natural products chemistry; infectious diseases; cancer; spectroscopy; drug discovery and development
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yoichi Nakao

E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
Interests: chemical biology; marine natural products; functional food science; epigenetics; stem cell biology; (including all above words in a concept of) chemical epigenomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the memory of Professor Paul J. Scheuer (1915–2003). In his more than fifty years at the University of Hawaii, Paul pioneered in marine toxin discovery and marine chemical ecological research, co-funded the modern marine natural product chemistry, authored over 300 scientific papers, and edited books inspiring many marine chemists and biologists. We invite those who knew Paul, those who were inspired by him, and others who want to commemorate his life’s work to contribute to this Special Issue.

Prof. Dr. Bill J. Baker
Prof. Dr. Mark T. Hamann
Prof. Dr. Yoichi Nakao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Editorial

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2 pages, 162 KiB  
Editorial
Commemorative Issue in Honor of Professor Paul J. Scheuer
by Bill J. Baker, Mark T. Hamann and Yoichi Nakao
Mar. Drugs 2022, 20(11), 678; https://doi.org/10.3390/md20110678 - 28 Oct 2022
Viewed by 1147
Abstract
This Special Issue is dedicated to the memory of Professor Paul J [...] Full article
(This article belongs to the Special Issue 20 Years Commemorative Issue in Honor of Professor Paul J. Scheuer)

Research

Jump to: Editorial

19 pages, 2163 KiB  
Article
Toxicogenomic Effects of Dissolved Saxitoxin on the Early Life Stages of the Longfin Yellowtail (Seriola rivoliana)
by Colleen Guinle, Erick Julián Núñez-Vázquez, Leyberth José Fernández-Herrera, Daniela Alejandra Corona-Rojas and Dariel Tovar-Ramírez
Mar. Drugs 2023, 21(11), 597; https://doi.org/10.3390/md21110597 - 18 Nov 2023
Cited by 2 | Viewed by 1935
Abstract
Harmful algal blooms (HABs) can produce a variety of noxious effects and, in some cases, the massive mortality of wild and farmed marine organisms. Some HAB species produce toxins that are released into seawater or transferred via food webs (particulate toxin fraction). The [...] Read more.
Harmful algal blooms (HABs) can produce a variety of noxious effects and, in some cases, the massive mortality of wild and farmed marine organisms. Some HAB species produce toxins that are released into seawater or transferred via food webs (particulate toxin fraction). The objective of the present study was to identify the toxicological effects of subacute exposure to saxitoxin (STX) during embryonic and early larval stages in Seriola rivoliana. Eggs were exposed to dissolved 19 STX (100 μg L−1). The toxic effects of STX were evaluated via the hatching percentage, the activity of three enzymes (protein and alkaline phosphatases and peroxidase), and the expression of four genes (HSF2, Nav1.4b, PPRC1, and DUSP8). A low hatching percentage (less than 5%) was observed in 44 hpf (hours post fertilization) embryos exposed to STX compared to 71% in the unexposed control. At this STX concentration, no oxidative stress in the embryos was evident. However, STX induced the expression of the NaV1.4 channel α-subunit (NaV1.4b), which is the primary target of this toxin. Our results revealed the overexpression of all four candidate genes in STX-intoxicated lecithotrophic larvae, reflecting the activation of diverse cellular processes involved in stress responses (HSF2), lipid metabolism (PPRC1), and MAP kinase signaling pathways associated with cell proliferation and differentiation (DUSP8). The effects of STX were more pronounced in young larvae than in embryos, indicating a stage-specific sensitivity to the toxin. Full article
(This article belongs to the Special Issue 20 Years Commemorative Issue in Honor of Professor Paul J. Scheuer)
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16 pages, 842 KiB  
Article
Hydantoanabaenopeptins from Lake Kinneret Microcystis Bloom, Isolation, and Structure Elucidation of the Possible Intermediates in the Anabaenopeptins Biosynthesis
by Shira Weisthal Algor, Assaf Sukenik and Shmuel Carmeli
Mar. Drugs 2023, 21(7), 401; https://doi.org/10.3390/md21070401 - 13 Jul 2023
Cited by 6 | Viewed by 1401
Abstract
Anabaenopeptins are common metabolites of cyanobacteria. In the course of reisolation of the known aeruginosins KT608A and KT608B for bioassay studies, we noticed the presence of some unknown anabaenopeptins in the extract of a Microcystis cell mass collected during the 2016 spring bloom [...] Read more.
Anabaenopeptins are common metabolites of cyanobacteria. In the course of reisolation of the known aeruginosins KT608A and KT608B for bioassay studies, we noticed the presence of some unknown anabaenopeptins in the extract of a Microcystis cell mass collected during the 2016 spring bloom event in Lake Kinneret, Israel. The 1H NMR spectra of some of these compounds presented a significant difference in the appearance of the ureido bridge protons, and their molecular masses did not match any one of the 152 known anabaenopeptins. Analyses of the 1D and 2D NMR, HRMS, and MS/MS spectra of the new compounds revealed their structures as the hydantoin derivatives of anabaenopeptins A, B, F, and 1[Dht]-anabaenopeptin A and oscillamide Y (1, 2, 3, 6, and 4, respectively) and a new anabaenopeptin, 1[Dht]-anabaenopeptin A (5). The known anabaenopeptins A, B, and F and oscillamide Y (7, 8, 9, and 10, respectively) were present in the extract as well. We propose that 1–4 and 6 are the possible missing intermediates in the previously proposed partial biosynthesis route to the anabaenopeptins. Compounds 1–6 were tested for inhibition of the serine proteases trypsin and chymotrypsin and found inactive at a final concentration of ca. 54 μM. Full article
(This article belongs to the Special Issue 20 Years Commemorative Issue in Honor of Professor Paul J. Scheuer)
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14 pages, 2602 KiB  
Article
Expanding the Utility of Bioinformatic Data for the Full Stereostructural Assignments of Marinolides A and B, 24- and 26-Membered Macrolactones Produced by a Chemically Exceptional Marine-Derived Bacterium
by Min Cheol Kim, Jaclyn M. Winter, Reiko Cullum, Alexander J. Smith and William Fenical
Mar. Drugs 2023, 21(6), 367; https://doi.org/10.3390/md21060367 - 20 Jun 2023
Cited by 1 | Viewed by 1955
Abstract
Marinolides A and B, two new 24- and 26-membered bacterial macrolactones, were isolated from the marine-derived actinobacterium AJS-327 and their stereostructures initially assigned by bioinformatic data analysis. Macrolactones typically possess complex stereochemistry, the assignments of which have been one of the most difficult [...] Read more.
Marinolides A and B, two new 24- and 26-membered bacterial macrolactones, were isolated from the marine-derived actinobacterium AJS-327 and their stereostructures initially assigned by bioinformatic data analysis. Macrolactones typically possess complex stereochemistry, the assignments of which have been one of the most difficult undertakings in natural products chemistry, and in most cases, the use of X-ray diffraction methods and total synthesis have been the major methods of assigning their absolute configurations. More recently, however, it has become apparent that the integration of bioinformatic data is growing in utility to assign absolute configurations. Genome mining and bioinformatic analysis identified the 97 kb mld biosynthetic cluster harboring seven type I polyketide synthases. A detailed bioinformatic investigation of the ketoreductase and enoylreductase domains within the multimodular polyketide synthases, coupled with NMR and X-ray diffraction data, allowed for the absolute configurations of marinolides A and B to be determined. While using bioinformatics to assign the relative and absolute configurations of natural products has high potential, this method must be coupled with full NMR-based analysis to both confirm bioinformatic assignments as well as any additional modifications that occur during biosynthesis. Full article
(This article belongs to the Special Issue 20 Years Commemorative Issue in Honor of Professor Paul J. Scheuer)
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