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Marine Drugs
Special Issues
Marine Products for Health and Beauty
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Marine Products for Health and Beauty

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 December 2017) | Viewed by 57024

Special Issue Editors

Prof. Dr. Anake Kijjoa

E-Mail Website
Guest Editor
ICBAS-Instituto de Ciências Biomédicas de Abel Salazar and CIMAR Universidade do Porto, 4099-003 Porto Portugal
Interests: antibacterial compounds from higher plants; marine invertebrates; soil and marine-derived fungi; cosmetic ingredients from marine resources; natural biopesticides
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Emília De Sousa

E-Mail Website1 Website2
Guest Editor
1. Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), 4450-208 Porto, Portugal
2. Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: medicinal chemistry; organic synthesis; heterocycles; P-glycoprotein; anticancer; antimicrobials; chiral drugs; marine natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our exploitation of the living wealth of the sea, which constitutes more than 70% of the world’s surface, is longstanding. Today, several industries have emerged from our mining of the ocean’s resources, based on bioactives from marine microbes; hydrocolloids, antioxidants and essential fatty acids from microalgae and seaweeds; and biomaterials, such as coral skeleton and collagen for human body repair. Marine-derived compounds have been proved to have great potentials as anti-cancer, anti-inflammatory, anti-parasitic and especially antimicrobial agents since their modes of action are often completely unrelated to terrestrial biochemistries, and, therefore, are able to overcome human and animal pathogen and cancer-cell defense mechanisms. Moreover, the incidence of obesity, has dramatically risen in recent years and many epidemic studies have shown that a prevalence of obesity-related diseases is lower in seafood-consuming population, suggesting a beneficial role of marine foods against obesity. It is believed that some functional ingredients in marine foods account for their anti-obesity effect. Antioxidant pigments (lutein and carotenoids), glucosamine, omega-3 fatty acids and minerals (calcium and magnesium) are also nutritionals from marine sources. On the other hand, marine molecules are expected to contribute strongly to cosmetics as well, because of increasing interest in antioxidants, anti-ageing and skin protection. Therefore, marine bioresources are expected to give rise to ‘marine biotechnology’ products, particularly functional ingredients for nutritionals, cosmetics and pharmaceuticals.

This Special Issue of Marine Drugs on “Marine Products for Health and Beauty” welcomes submission of previously unpublished manuscripts from original work or reviews on all the above aspects, including chemistry and biological activity of chemopreventive and anti-obesogenic compounds, marine products used in cosmeceuticals and nutraceuticals, health and beauty product development and innovation. We plan to receive submissions until 30 October 2017.

Prof. Dr. Anake Kijjoa
Prof. Dr. Maria Emília Sousa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine-derived compounds

  • Marine organisms

  • Nutraceuticals

  • Cosmeceuticals

  • Anti-ageing

  • Skin-protection

  • Anti-obesity

  • Chemoprevention

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Published Papers (7 papers)

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Research

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1377 KiB  
Article
A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213
by Decha Kumla, Tin Shine Aung, Suradet Buttachon, Tida Dethoup, Luís Gales, José A. Pereira, Ângela Inácio, Paulo M. Costa, Michael Lee, Nazim Sekeroglu, Artur M. S. Silva, Madalena M. M. Pinto and Anake Kijjoa
Mar. Drugs 2017, 15(12), 375; https://doi.org/10.3390/md15120375 - 1 Dec 2017
Cited by 37 | Viewed by 7922
Abstract
A previously unreported dihydrochromone dimer, paecilin E (1), was isolated, together with eleven known compounds: β-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (2), helvolic acid, secalonic acid A and fellutanine A, [...] Read more.
A previously unreported dihydrochromone dimer, paecilin E (1), was isolated, together with eleven known compounds: β-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (2), helvolic acid, secalonic acid A and fellutanine A, from the culture filtrate extract of the marine sponge-associated fungus Neosartorya fennelliae KUFA 0811. Nine previously reported metabolites, including a chromanol derivative (3), (3β, 5α, 22E), 3,5-dihydroxyergosta-7,22-dien-6-one (4), byssochlamic acid, hopan-3β,22-diol, chevalone C, sartorypyrone B, helvolic acid, lumichrome and the alkaloid harmane were isolated from the culture of the marine-sponge associated fungus Neosartorya tsunodae KUFC 9213. Paecilin E (1), dankasterone A (2), a chromanol derivative (3), (3β, 5α, 22E)-3,5-dihydroxyergosta-7,22-dien-6-one (4), hopan-3β,22-diol (5), lumichrome (6), and harmane (7) were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. While paecilin E (1) was active against S. aureus ATCC 29213 and E. faecalis ATCC 29212, dankastetrone A (2) was only effective against E. faecalis ATCC 29212 and the multidrug-resistant VRE E. faecalis A5/102. Both compounds neither inhibit biofilm mass production in any of the strains at the concentrations tested nor exhibit synergistic association with antibiotics. Full article
(This article belongs to the Special Issue Marine Products for Health and Beauty)
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4348 KiB  
Article
Different Levels of Skin Whitening Activity among 3,6-Anhydro-l-galactose, Agarooligosaccharides, and Neoagarooligosaccharides
by Ji Hye Kim, Eun Ju Yun, Sora Yu, Kyoung Heon Kim and Nam Joo Kang
Mar. Drugs 2017, 15(10), 321; https://doi.org/10.3390/md15100321 - 20 Oct 2017
Cited by 71 | Viewed by 7018
Abstract
3,6-Anhydro-l-galactose (AHG), a major monomeric constituent of red macroalgae (Rhodophyta), was recently reported to possess skin whitening activity. Moreover, AHG-containing oligosaccharides, such as agarooligosaccharides (AOSs) and neoagarooligosaccharides (NAOSs), have various physiological activities, including anti-inflammatory, antioxidant, and skin moisturizing effects. [...] Read more.
3,6-Anhydro-l-galactose (AHG), a major monomeric constituent of red macroalgae (Rhodophyta), was recently reported to possess skin whitening activity. Moreover, AHG-containing oligosaccharides, such as agarooligosaccharides (AOSs) and neoagarooligosaccharides (NAOSs), have various physiological activities, including anti-inflammatory, antioxidant, and skin moisturizing effects. In this study, AHG and NAOSs were produced from agarose by enzymatic reactions catalyzed by an endo-type β-agarase, an exo-type β-agarase, and a neoagarobiose hydrolase. In a cell proliferation assay, AHG, AOSs, and NAOSs at 12.5, 25, and 50 μg/mL concentrations did not exhibit cytotoxicity toward murine B16 melanoma cells or human epidermal melanocytes. In an in vitro skin whitening activity assay of AHG, AOSs, and NAOSs at 50 μg/mL, AHG showed the highest skin whitening activity in both murine B16 melanoma cells and human epidermal melanocytes; this activity was mediated by the inhibition of melanogenesis. Neoagarotetraose and neoagarohexaose also exhibited in vitro skin whitening activity, whereas neoagarobiose and AOSs with degrees of polymerization of 3 (agarotriose), 5 (agaropentaose), and 7 (agaroheptaose) did not. Therefore, AHG is responsible for the skin whitening activity of agar-derived sugars, and the structural differences among the AHG-containing oligosaccharides may be responsible for their different skin whitening activities. Full article
(This article belongs to the Special Issue Marine Products for Health and Beauty)
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3180 KiB  
Article
Construction of a Fluorescent H2O2 Biosensor with Chitosan 6-OH Immobilized β-Cyclodextrin Derivatives
by Wenbo Dong, Weiping Li, Yu Chen, Yanchun Ye and Shaohua Jin
Mar. Drugs 2017, 15(9), 284; https://doi.org/10.3390/md15090284 - 4 Sep 2017
Cited by 4 | Viewed by 4844
Abstract
In the present work, a fluorescent H2O2 biosensor was constructed by encapsulating fluorescent probe Rhodamine B (RhmB) in the hydrophobic cavity of the cyclodextrin (β-CD) and immobilizing catalase (CAT) on the 2-NH2 of chitosan (CTS) in a chitosan 6-OH [...] Read more.
In the present work, a fluorescent H2O2 biosensor was constructed by encapsulating fluorescent probe Rhodamine B (RhmB) in the hydrophobic cavity of the cyclodextrin (β-CD) and immobilizing catalase (CAT) on the 2-NH2 of chitosan (CTS) in a chitosan 6-OH immobilized β-cyclodextrin derivative (CTS-6-CD). The inclusion complex of CTS-6-CD to RhmB (CTS-6-CD-RhmB) was prepared by a solution method. Its structure and inclusion efficiency were determined by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and fluorescence spectroscopy (FL). CAT was immobilized on CTS-6-CD-RhmB to eventually form the functional membrane, CTS-6-CD-RhmB-CAT, via glutaraldehyde crosslinking, which was further characterized by FTIR and FL, and used as a H2O2 biosensor. The functional membrane was used to simultaneously oxidize and detect H2O2. The detection condition was optimized as pH 8, a reaction temperature of 25 °C, and an immobilized enzyme concentration of 2 × 10−4 mol/L. The fluorescence response of the biosensor exhibited a good linear relationship with the concentration of H2O2 in the range of 20 mΜ–300 μM and the detection limit of 10−8 mol/L. Full article
(This article belongs to the Special Issue Marine Products for Health and Beauty)
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4385 KiB  
Article
Genome Sequence of Pseudomonas stutzeri 273 and Identification of the Exopolysaccharide EPS273 Biosynthesis Locus
by Shimei Wu, Rikuan Zheng, Zhenxia Sha and Chaomin Sun
Mar. Drugs 2017, 15(7), 218; https://doi.org/10.3390/md15070218 - 10 Jul 2017
Cited by 15 | Viewed by 6494
Abstract
Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P. stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of [...] Read more.
Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P. stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus containing 18 genes was predicted to be involved in the biosynthesis of EPS273. In order to confirm this prediction, two adjacent genes (eps273-H and eps273-I) encoding glycosyltransferases and one gene (eps273-O) encoding tyrosine protein kinase within the genetic locus were deleted and biosynthesis of EPS273 was checked in parallel. The molecular weight profile of EPS purified from the mutant Δeps273-HI was obviously different from that purified from wild-type P. stutzeri 273, while the corresponding EPS was hardly detected from the mutant Δeps273-O, which indicated the involvement of the proposed 18-gene cluster in the biosynthesis of EPS273. Moreover, the mutant Δeps273-HI had the biofilm formed earlier compared with the wild type, and the mutant Δeps273-O almost completely lost the ability of biofilm formation. Therefore, EPS273 might facilitate the biofilm formation for its producing strain P. stutzeri 273 while inhibiting the biofilm formation of P. aeruginosa PAO1. This study can contribute to better understanding of the biosynthesis of EPS273 and disclose the biological function of EPS273 for its producing strain P. stutzeri 273. Full article
(This article belongs to the Special Issue Marine Products for Health and Beauty)
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3460 KiB  
Article
A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-Obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces stipitatus KUFA 0207
by Jidapa Noinart, Suradet Buttachon, Tida Dethoup, Luís Gales, José A. Pereira, Ralph Urbatzka, Sara Freitas, Michael Lee, Artur M. S. Silva, Madalena M. M. Pinto, Vítor Vasconcelos and Anake Kijjoa
Mar. Drugs 2017, 15(5), 139; https://doi.org/10.3390/md15050139 - 16 May 2017
Cited by 48 | Viewed by 7617
Abstract
A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22-tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), questinol (4b), citreorosein ( [...] Read more.
A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22-tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), questinol (4b), citreorosein (4c), fallacinol (4d), rheoemodin (4e) and secalonic acid A (5), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis, and in the case of talarosterone (1), the absolute configurations of its stereogenic carbons were determined by X-ray crystallographic analysis. The structure and stereochemistry of cyathisterone (2) was also confirmed by X-ray analysis. The anthraquinones 4a–e and secalonic acid A (5) were tested for their anti-obesity activity using the zebrafish Nile red assay. Only citreorosein (4c) and questinol (4b) exhibited significant anti-obesity activity, while emodin (4a) and secalonic acid A (5) caused toxicity (death) for all exposed zebrafish larvae after 24 h. Full article
(This article belongs to the Special Issue Marine Products for Health and Beauty)
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Review

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663 KiB  
Review
Mycosporine-Like Amino Acids: Potential Health and Beauty Ingredients
by Ewelina Chrapusta, Ariel Kaminski, Kornelia Duchnik, Beata Bober, Michal Adamski and Jan Bialczyk
Mar. Drugs 2017, 15(10), 326; https://doi.org/10.3390/md15100326 - 21 Oct 2017
Cited by 141 | Viewed by 13370
Abstract
Human skin is constantly exposed to damaging ultraviolet radiation (UVR), which induces a number of acute and chronic disorders. To reduce the risk of UV-induced skin injury, people apply an additional external protection in the form of cosmetic products containing sunscreens. Nowadays, because [...] Read more.
Human skin is constantly exposed to damaging ultraviolet radiation (UVR), which induces a number of acute and chronic disorders. To reduce the risk of UV-induced skin injury, people apply an additional external protection in the form of cosmetic products containing sunscreens. Nowadays, because of the use of some chemical filters raises a lot of controversies, research focuses on exploring novel, fully safe and highly efficient natural UV-absorbing compounds that could be used as active ingredients in sun care products. A promising alternative is the application of multifunctional mycosporine-like amino acids (MAAs), which can effectively compete with commercially available filters. Here, we outline a complete characterization of these compounds and discuss their enormous biotechnological potential with special emphasis on their use as sunscreens, activators of cells proliferation, anti-cancer agents, anti-photoaging molecules, stimulators of skin renewal, and functional ingredients of UV-protective biomaterials. Full article
(This article belongs to the Special Issue Marine Products for Health and Beauty)
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1280 KiB  
Review
Hypopigmenting Effects of Brown Algae-Derived Phytochemicals: A Review on Molecular Mechanisms
by Mohammed Shariful Azam, Jinkyung Choi, Min-Sup Lee and Hyeung-Rak Kim
Mar. Drugs 2017, 15(10), 297; https://doi.org/10.3390/md15100297 - 24 Sep 2017
Cited by 50 | Viewed by 8335
Abstract
There is a rapid increase in the demand for natural hypopigmenting agents from marine sources for cosmeceutical and pharmaceutical applications. Currently, marine macroalgae are considered as a safe and effective source of diverse bioactive compounds. Many research groups are exploring marine macroalgae to [...] Read more.
There is a rapid increase in the demand for natural hypopigmenting agents from marine sources for cosmeceutical and pharmaceutical applications. Currently, marine macroalgae are considered as a safe and effective source of diverse bioactive compounds. Many research groups are exploring marine macroalgae to discover and characterize novel compounds for cosmeceutical, nutraceutical, and pharmaceutical applications. Many types of bioactive secondary metabolites from marine algae, including phlorotannins, sulfated polysaccharides, carotenoids, and meroterpenoids, have already been documented for their potential applications in the pharmaceutical industry. Among these metabolites, phlorotannins from brown algae have been widely screened for their pharmaceutical and hypopigmenting effects. Unfortunately, the majority of these articles did not have detailed investigations on molecular targets, which is critical to fulfilling the criteria for their cosmeceutical and pharmaceutical use. Very recently, a few meroterpenoids have been discovered from Sargassum sp., with the examination of their anti-melanogenic properties and mechanisms. Despite the scarcity of in vivo and clinical investigations of molecular mechanistic events of marine algae-derived hypopigmenting agents, identifying the therapeutic targets and their validation in humans has been a major challenge for future studies. In this review, we focused on available data representing molecular mechanisms underlying hypopigmenting properties of potential marine brown alga-derived compounds. Full article
(This article belongs to the Special Issue Marine Products for Health and Beauty)
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