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Synthesis, Degradation and Biocompatibility of Bioresorbable Materials
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Synthesis, Degradation and Biocompatibility of Bioresorbable Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2260

Special Issue Editors

Dr. Sandra Carolina Cifuentes Cuéllar

E-Mail Website
Guest Editor
Department of Applied Mathematics, Materials Science and Engineering and Electronic Technology, ESCET, Universidad Rey Juan Carlos, Madrid, Spain
Interests: bioresorbable metals and polymers; polymer/metal composites; bioactive ceramics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Juan Pablo Fernández Hernán

E-Mail Website
Guest Editor Assistant
Área de Ciencia e Ingeniería de Materiales, ESCET, Universidad Rey Juan Carlos, Madrid, Spain
Interests: biomaterials; sol–gel; plasma electrolytic oxidation; bioabsorbable metals; biocompatibility; cell culture

Special Issue Information

Dear Colleagues,

Biomaterials play a significant role in medicine, improving the quality of life of patients. The search to develop appropriate implants or adequate methods that allow the healing of human tissues enhances the need for understanding the behavior of biomaterials in the human body. The use of bioresorbable materials in different medical applications is increasing, as there is a need to develop medical devices that are metabolized by the human body once they have fulfilled their task. In this sense, the main objective of this Special Issue is to highlight knowledge on the synthesis, degradation, and biocompatibility of bioresorbable materials. We welcome novel scientific research on themes including, but not limited to, the following:

(i) Bioresorbable metals and alloys;

(ii) Biopolymers and gels;

(iii) Bioactive ceramics and glasses;

(iv) Biocomposites;

(v) Surface treatments.

Dr. Sandra Carolina Cifuentes Cuéllar
Guest Editor
Prof. Dr. Juan Pablo Fernández Hernán
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthesis
  • degradation
  • biocompatibility
  • bioactivity
  • antibacterial response
  • bioresorbable metals
  • biopolymers
  • bioceramics

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Published Papers (2 papers)

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Research

19 pages, 6047 KiB  
Article
Characterization of Iron Oxide Nanotubes Obtained by Anodic Oxidation for Biomedical Applications—In Vitro Studies
by Rita de Cássia Reis Rangel, André Luiz Reis Rangel, Kerolene Barboza da Silva, Ana Lúcia do Amaral Escada, Javier Andres Munoz Chaves, Fátima Raquel Maia, Sandra Pina, Rui L. Reis, Joaquim M. Oliveira and Ana Paula Rosifini Alves
Materials 2024, 17(15), 3627; https://doi.org/10.3390/ma17153627 - 23 Jul 2024
Cited by 1 | Viewed by 925
Abstract
To improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 V–30 [...] Read more.
To improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 V–30 min, using an ethylene glycol solution containing 0.3% NH4F and 3% H2O, at a speed of 100 rpm). A nanotube layer composed mainly of α-Fe2O3 with diameters between 60 and 70 nm was obtained. The effect of the Fe-oxide nanotube layer on cell viability and morphology was evaluated by in vitro studies using a human osteosarcoma cell line (SaOs-2 cells). The results showed that the presence of this layer did not harm the viability or morphology of the cells. Furthermore, cells cultured on anodized surfaces showed higher metabolic activity than those on non-anodized surfaces. This research suggests that growing a layer of Fe oxide nanotubes on pure Fe is a promising method for functionalizing and improving the cytocompatibility of iron substrates. This opens up new opportunities for biomedical applications, including the development of cardiovascular stents or osteosynthesis implants. Full article
(This article belongs to the Special Issue Synthesis, Degradation and Biocompatibility of Bioresorbable Materials)
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21 pages, 5652 KiB  
Article
Dynamic Adhesive Behavior and Biofilm Formation of Staphylococcus aureus on Polylactic Acid Surfaces in Diabetic Environments
by María Fernández-Grajera, Miguel A. Pacha-Olivenza, María Coronada Fernández-Calderón, María Luisa González-Martín and Amparo M. Gallardo-Moreno
Materials 2024, 17(13), 3349; https://doi.org/10.3390/ma17133349 - 6 Jul 2024
Viewed by 909
Abstract
Interest in biodegradable implants has focused attention on the resorbable polymer polylactic acid. However, the risk of these materials promoting infection, especially in patients with existing pathologies, needs to be monitored. The enrichment of a bacterial adhesion medium with compounds that are associated [...] Read more.
Interest in biodegradable implants has focused attention on the resorbable polymer polylactic acid. However, the risk of these materials promoting infection, especially in patients with existing pathologies, needs to be monitored. The enrichment of a bacterial adhesion medium with compounds that are associated with human pathologies can help in understanding how these components affect the development of infectious processes. Specifically, this work evaluates the influence of glucose and ketone bodies (in a diabetic context) on the adhesion dynamics of S. aureus to the biomaterial polylactic acid, employing different approaches and discussing the results based on the physical properties of the bacterial surface and its metabolic activity. The combination of ketoacidosis and hyperglycemia (GK2) appears to be the worst scenario: this system promotes a state of continuous bacterial colonization over time, suppressing the stationary phase of adhesion and strengthening the attachment of bacteria to the surface. In addition, these supplements cause a significant increase in the metabolic activity of the bacteria. Compared to non-enriched media, biofilm formation doubles under ketoacidosis conditions, while in the planktonic state, it is glucose that triggers metabolic activity, which is practically suppressed when only ketone components are present. Both information must be complementary to understand what can happen in a real system, where planktonic bacteria are the ones that initially colonize a surface, and, subsequently, these attached bacteria end up forming a biofilm. This information highlights the need for good monitoring of diabetic patients, especially if they use an implanted device made of PLA. Full article
(This article belongs to the Special Issue Synthesis, Degradation and Biocompatibility of Bioresorbable Materials)
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