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Advances in Biological Nanomaterials (Volume II)
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Advances in Biological Nanomaterials (Volume II)

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 3959

Special Issue Editor

Dr. Camelia Ungureanu

E-Mail Website
Guest Editor
Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology POLITEHNICA Bucharest, Gheorghe Polizu 1-7 Street, 011061 Bucharest, Romania
Interests: biotechnology; food chemistry; antimicrobial activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research on novel materials and advances in biological nanomaterials has expanded in recent years, attracting interest from academic and industrial researchers worldwide, particularly in the biomedical applications of nanotechnology, driven by the outstanding benefits that their translation can offer, e.g., an enhancement of the sensitivity, efficacy, and safety of existing diagnostic, treatment, and combination strategies.

In this Special Issue, we expect contributions from a broad community of scientists working on diverse applications of nanotechnology in biology/medicine and interdisciplinary teams focusing on nanotechnology.

In particular, the topics of interest include but are not limited to, the safety of novel nanomaterials intended for use on humans.

Dr. Camelia Ungureanu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocarriers for drug delivery
  • multifunctional nanoprobes
  • biocompatible and antimicrobial nanomaterials
  • diagnostic nanosystems and sensors
  • personalized nanomedicines
  • nanomaterials safety

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Published Papers (2 papers)

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Research

14 pages, 3203 KiB  
Article
Assessing the Adjuvant Effect of Layered Double Hydroxides (LDH) on BALB/c Mice
by Dania O. Govea-Alonso, Mariano J. García-Soto, Emilio Sebastián Mendoza-Pérez, Susan Farfán-Castro, Diana Fuente, Omar González-Ortega and Sergio Rosales-Mendoza
Materials 2023, 16(15), 5467; https://doi.org/10.3390/ma16155467 - 4 Aug 2023
Cited by 4 | Viewed by 1571
Abstract
The discovery and validation of new adjuvants are critical areas for vaccinology. Mineral materials (e.g., alum microparticles) have been used for a long time as adjuvants in human vaccine formulations. Nonetheless, the use of nanosized materials is a promising approach to diversify the [...] Read more.
The discovery and validation of new adjuvants are critical areas for vaccinology. Mineral materials (e.g., alum microparticles) have been used for a long time as adjuvants in human vaccine formulations. Nonetheless, the use of nanosized materials is a promising approach to diversify the properties of adjuvants. Nanoclays are potential adjuvants proposed by some research groups. However, their adjuvant mechanisms and safety have not been fully elucidated. Herein, we aimed at expanding the knowledge on the potential adjuvanticity of layered double hydroxide (LDH) nanoparticles by reporting a detailed method for the synthesis and characterization of LDHs and the adsorption of a model antigen (bovine serum albumin, BSA). LDHs varying in diameter (from 56 to 88 nm) were obtained, and an in vitro evaluation revealed that the LDHs are not inherently toxic. BSA was passively adsorbed onto the LDHs, and the immunogenicity in mice of the conjugates obtained was compared to that of free BSA and BSA co-administered with alum (Alum–BSA). The LDH–BSA conjugates induced a higher humoral response that lasted for a longer period compared with that of free BSA and Alum–BSA, confirming that LDH exerts adjuvant effects. The 56 nm LDH particles were deemed as the more efficient carrier since they induced a higher and more balanced Th1/Th2 response than the 88 nm particles. This study is a contribution toward expanding the characterization and use of nanoclays in vaccinology and justifies further studies with pathogen-specific antigens. Full article
(This article belongs to the Special Issue Advances in Biological Nanomaterials (Volume II))
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25 pages, 14411 KiB  
Article
Phytosynthesis of Silver Nanoparticles Using Leonurus cardiaca L. Extracts
by Ioana Catalina Fierascu, Irina Fierascu, Anda Maria Baroi, Camelia Ungureanu, Simona Spinu, Sorin Marius Avramescu, Raluca Somoghi, Radu Claudiu Fierascu and Cristina Elena Dinu-Parvu
Materials 2023, 16(9), 3472; https://doi.org/10.3390/ma16093472 - 29 Apr 2023
Cited by 7 | Viewed by 1944
Abstract
The present work describes, for the first time in the literature, the phytosynthesis of silver nanoparticles using Leonurus cardiaca L. extracts. The influence of the extraction method (classical temperature extraction and microwave extraction), as well as of the extract concentration on the characteristics [...] Read more.
The present work describes, for the first time in the literature, the phytosynthesis of silver nanoparticles using Leonurus cardiaca L. extracts. The influence of the extraction method (classical temperature extraction and microwave extraction), as well as of the extract concentration on the characteristics of the nanoparticles, was studied using analytical methods, such as UV-Vis spectrometry, X-ray diffraction, dynamic light scattering, and transmission electron microscopy. Experimental data suggest that use of lower extract concentration leads to smaller dimensions nanoparticles, the same effect using the extract obtained by microwave-assisted extraction. The smallest recorded crystallite sizes (by X-ray diffraction) were under 3 nm. The antioxidant properties (determined by the DPPH assay) and the antimicrobial potential (determined against Gram-negative and Gram-positive strains) are enhanced by the phytosynthesis process (as demonstrated by the comparison of the nanoparticles’ properties with the parent extracts). The present work could also represent an important step in obtaining nanoparticles with enhanced properties and controlled morphologies, but also offers information on the phytosynthesis of metallic nanoparticles using low extract concentrations. Full article
(This article belongs to the Special Issue Advances in Biological Nanomaterials (Volume II))
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