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Dr. Sylwia Męczyńska-Wielgosz

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Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
Interests: nanotoxicology; oxidative stress; free radicals; radiopharmaceuticals

Special Issue Information

Dear Colleagues,

A rapid development of nanotechnology observed in recent years causes an increase in exposure of humans and the natural environment to the potentially adverse effect of. An unfavourable impact of an increase in the number of products containing nanoparticles is their uncontrolled release into the environment. Despite an increasing number of studies indicating benefits from the use of nanomaterials in daily life, relatively little is known about the risk, which they cause for human health. Due to the size and mobility of nanoparticles, they may overcome barriers in the body, and accumulate in the brain or other organs, leading probably to their damage. Nanoparticles have been reported to induce oxidative stress, DNA damage, inflammation, and many other adverse effects which are known to be crucial for the development of lifestyle diseases. This Special Issue focuses on the use of organic/inorganic nanomaterials for health care applications (diagnosis and treatment) and also on the in vitro and in vivo interactions of nanomaterials with biological systems from biological macromolecules through to cells, tissues, and up to the whole organism. It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Dr. Sylwia Męczyńska-Wielgosz
Guest Editor

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Research

16 pages, 16616 KiB

Open AccessArticle

Silver Nanoparticles Inhibit Metastasis of 4T1 Tumor in Mice after Intragastric but Not Intravenous Administration

by Kamil Brzóska, Maria Wojewódzka, Małgorzata Szczygiel, Agnieszka Drzał, Martyna Sniegocka, Dominika Michalczyk-Wetula, Eva Biela, Martyna Elas, Małgorzata Kucińska, Hanna Piotrowska-Kempisty, Lucyna Kapka-Skrzypczak, Marek Murias, Krystyna Urbańska and Marcin Kruszewski

Materials 2022, 15(11), 3837; https://doi.org/10.3390/ma15113837 - 27 May 2022

Cited by 7 | Viewed by 2114

Abstract

The potential anticancer activity of different silver nanoformulations is increasingly recognized. In the present work, we use the model of 4T1 tumor in BALB/ccmdb immunocompetent mice to analyze the impact of citrate- and PEG-coated silver nanoparticles (AgNPs) on the development and metastatic potential of breast cancer. One group of mice was intragastrically administered with 1 mg/kg body weight (b.w.) of AgNPs daily from day 1 to day 14 after cancer cells implantation (total dose 14 mg/kg b.w.). The second group was intravenously administered twice with 1 or 5 mg/kg b.w. of AgNPs. A tendency for lowering tumor volume on day 21 (mean volumes 491.31, 428.88, and 386.83 mm³ for control, AgNPs-PEG, and AgNPs-citrate, respectively) and day 26 (mean volumes 903.20, 764.27, and 672.62 mm³ for control, AgNPs-PEG, and AgNPs-citrate, respectively) has been observed in mice treated intragastrically, but the effect did not reach the level of statistical significance. Interestingly, in mice treated intragastrically with citrate-coated AgNPs, the number of lung metastases was significantly lower, as compared to control mice (the mean number of metastases 18.89, 14.90, and 8.03 for control, AgNPs-PEG, and AgNPs-citrate, respectively). No effect of AgNPs treatment on the number of lung metastases was observed after intravenous administration (the mean number of metastases 12.44, 9.86, 12.88, 11.05, and 10.5 for control, AgNPs-PEG 1 mg/kg, AgNPs-PEG 5 mg/kg, AgNPs-citrate 1 mg/kg, and AgNPs-citrate 5 mg/kg, respectively). Surprisingly, inhibition of metastasis was not accompanied by changes in the expression of genes associated with epithelial–mesenchymal transition. Instead, changes in the expression of inflammation-related genes were observed. The presented results support the antitumor activity of AgNPs in vivo, but the effect was limited to the inhibition of metastasis. Moreover, our results clearly point to the importance of AgNPs coating and route of administration for its anticancer activity. Finally, our study supports the previous findings that antitumor AgNPs activity may depend on the activation of the immune system and not on the direct action of AgNPs on cancer cells. Full article

(This article belongs to the Special Issue Nanoparticles and Nanomaterials for Medicine and Biology)

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16 pages, 1965 KiB

Open AccessArticle

Silver Nanoparticles Effects on In Vitro Germination, Growth, and Biochemical Activity of Tomato, Radish, and Kale Seedlings

by Alicja Tymoszuk

Materials 2021, 14(18), 5340; https://doi.org/10.3390/ma14185340 - 16 Sep 2021

Cited by 36 | Viewed by 3723

Abstract

The interactions between nanoparticles and plant cells are still not sufficiently understood, and studies related to this subject are of scientific and practical importance. Silver nanoparticles (AgNPs) are one of the most commonly produced and used nanomaterials. This study aimed to investigate the influence of AgNPs applied at the concentrations of 0, 50, and 100 mg·L⁻¹ during the process of in vitro germination as well as the biometric and biochemical parameters of developed seedlings in three vegetable species: Solanum lycopersicum L. ‘Poranek’, Raphanus sativus L. var. sativus ‘Ramona’, and Brassica oleracea var. sabellica ‘Nero di Toscana’. The application of AgNPs did not affect the germination efficiency; however, diverse results were reported for the growth and biochemical activity of the seedlings, depending on the species tested and the AgNPs concentration. Tomato seedlings treated with nanoparticles, particularly at 100 mg·L⁻¹, had shorter shoots with lower fresh and dry weights and produced roots with lower fresh weight. Simultaneously, at the biochemical level, a decrease in the content of chlorophylls and carotenoids and an increase in the anthocyanins content and guaiacol peroxidase (GPOX) activity were reported. AgNPs-treated radish plants had shorter shoots of higher fresh and dry weight and longer roots with lower fresh weight. Treatment with 50 mg·L⁻¹ and 100 mg·L⁻¹ resulted in the highest and lowest accumulation of chlorophylls and carotenoids in the leaves, respectively; however, seedlings treated with 100 mg·L⁻¹ produced less anthocyanins and polyphenols and exhibited lower GPOX activity. In kale, AgNPs-derived seedlings had a lower content of chlorophylls, carotenoids, and anthocyanins but higher GPOX activity of and were characterized by higher fresh and dry shoot weights and higher heterogeneous biometric parameters of the roots. The results of these experiments may be of great significance for broadening the scope of knowledge on the influence of AgNPs on plant cells and the micropropagation of the vegetable species. Future studies should be aimed at testing lower or even higher concentrations of AgNPs and other NPs and to evaluate the genetic stability of NPs-treated vegetable crops and their yielding efficiency. Full article

(This article belongs to the Special Issue Nanoparticles and Nanomaterials for Medicine and Biology)

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