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Nanozyme: Synthesis, Mechanisms, and Applications

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 15444

Special Issue Editors

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
Interests: biomaterials; metal–organic frameworks; nanozymes; cancer treatment; antibacteria
Special Issues, Collections and Topics in MDPI journals
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
Interests: biogenic nanoparticles; catalysts; nanozymes; cancer treatment; antibacteria

Special Issue Information

Dear Colleagues,

Natural phenomena are associated with enzymes, including many proteases with non-metal or metal as their catalytically active center (cofactor), which contribute to the efficiency of biochemical reactions and play a role in maintaining normal activities in living systems on Earth. Nanozymes are nanomaterials with enzyme-mimicking activities. Nanozymes are advantageous compared to natural enzymes due to their low cost, high stability, and long-term resistance to harsh conditions, and to date, numerous nanomaterials have been reported with enzyme-mimicking activities, such as Fe3O4 nanoparticles, noble metal nanoparticles, carbon nanostructures, metal–organic frameworks, etc. The enzymatic activities of nanozymes are usually associated with many factors, such as shape, facet, size, and even surface properties of nanomaterials. Thus, the development of nanozymes mainly relies on trial-and-error strategies, and our understanding of their mechanisms and the rules guiding their synthesis is limited. This greatly compromises the development of highly active and selective nanozymes.

To meet these challenges, the rational design of high-performance nanozymes is extremely important. The aim of this issue is to showcase unique enzyme-mimicking activities, explore solutions improving the catalytic ability of nanozymes, and study the mechanisms of catalytic reactions of nanozymes. By collecting knowledge in this field and covering a large number of synthesis methods and nanozyme applications, we aim to increase their scientific and commercial value in the field of cancer treatment, biosensing/imaging, antibacteria, ROS scavengers, environmental protection, heterogeneous catalysis, and enzymatic catalysis. Topics of interest may be related to the following areas:

  1. Synthetic strategies and applications of various enzyme-mimicking nanomaterials;
  2. Precise tailoring of the enzymatic activities of nanozymes;
  3. Mechanism understanding of nanozymes;
  4. Structural identification of nanozymes;
  5. DFT calculations of nanozymes;
  6. Single-atomic nanozymes.

Dr. Dongdong Wang
Dr. Jiawei Liu
Guest Editors

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Keywords

  • nanozymes
  • enzyme-mimicking
  • artificial enzymes
  • cancer treatment
  • biosensing/imaging
  • antibacteria
  • ROS scavenger
  • pollutant elimination
  • enzymatic catalysis
  • advanced catalysis

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Published Papers (2 papers)

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Review

24 pages, 2348 KiB  
Review
Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications
by Dario Presutti, Tarun Agarwal, Atefeh Zarepour, Nehar Celikkin, Sara Hooshmand, Chinmay Nayak, Matineh Ghomi, Ali Zarrabi, Marco Costantini, Birendra Behera and Tapas Kumar Maiti
Materials 2022, 15(1), 337; https://doi.org/10.3390/ma15010337 - 4 Jan 2022
Cited by 36 | Viewed by 9171
Abstract
Nanozymes, a type of nanomaterial with enzyme-like properties, are a promising alternative to natural enzymes. In particular, transition metal dichalcogenides (TMDCs, with the general formula MX2, where M represents a transition metal and X is a chalcogen element)-based nanozymes have demonstrated [...] Read more.
Nanozymes, a type of nanomaterial with enzyme-like properties, are a promising alternative to natural enzymes. In particular, transition metal dichalcogenides (TMDCs, with the general formula MX2, where M represents a transition metal and X is a chalcogen element)-based nanozymes have demonstrated exceptional potential in the healthcare and diagnostic sectors. TMDCs have different enzymatic properties due to their unique nano-architecture, high surface area, and semiconducting properties with tunable band gaps. Furthermore, the compatibility of TMDCs with various chemical or physical modification strategies provide a simple and scalable way to engineer and control their enzymatic activity. Here, we discuss recent advances made with TMDC-based nanozymes for biosensing and therapeutic applications. We also discuss their synthesis strategies, various enzymatic properties, current challenges, and the outlook for future developments in this field. Full article
(This article belongs to the Special Issue Nanozyme: Synthesis, Mechanisms, and Applications)
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25 pages, 1521 KiB  
Review
Potentiality of Nanoenzymes for Cancer Treatment and Other Diseases: Current Status and Future Challenges
by Rakesh K. Sindhu, Agnieszka Najda, Prabhjot Kaur, Muddaser Shah, Harmanpreet Singh, Parneet Kaur, Simona Cavalu, Monika Jaroszuk-Sierocińska and Md. Habibur Rahman
Materials 2021, 14(20), 5965; https://doi.org/10.3390/ma14205965 - 11 Oct 2021
Cited by 37 | Viewed by 4866
Abstract
Studies from past years have observed various enzymes that are artificial, which are issued to mimic naturally occurring enzymes based on their function and structure. The nanozymes possess nanomaterials that resemble natural enzymes and are considered an innovative class. This innovative class has [...] Read more.
Studies from past years have observed various enzymes that are artificial, which are issued to mimic naturally occurring enzymes based on their function and structure. The nanozymes possess nanomaterials that resemble natural enzymes and are considered an innovative class. This innovative class has achieved a brilliant response from various developments and researchers owing to this unique property. In this regard, numerous nanomaterials are inspected as natural enzyme mimics for multiple types of applications, such as imaging, water treatment, therapeutics, and sensing. Nanozymes have nanomaterial properties occurring with an inheritance that provides a single substitute and multiple platforms. Nanozymes can be controlled remotely via stimuli including heat, light, magnetic field, and ultrasound. Collectively, these all can be used to increase the therapeutic as well as diagnostic efficacies. These nanozymes have major biomedical applications including cancer therapy and diagnosis, medical diagnostics, and bio sensing. We summarized and emphasized the latest progress of nanozymes, including their biomedical mechanisms and applications involving synergistic and remote control nanozymes. Finally, we cover the challenges and limitations of further improving therapeutic applications and provide a future direction for using engineered nanozymes with enhanced biomedical and diagnostic applications. Full article
(This article belongs to the Special Issue Nanozyme: Synthesis, Mechanisms, and Applications)
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