Biofunctionalized Scaffolds in Regenerative Medicine
A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 85
Special Issue Editors
Interests: regenerative medicine; stem cells; oral stem cells; biomaterials; extracellular vesicles; exosomes; epithelial- mesenchymal transition
Special Issues, Collections and Topics in MDPI journals
Interests: regenerative medicine; stem cells; biomaterials; extracellular vesicles; exosomes; cardiac regeneration; cardiomyocytes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The use of biofunctionalized scaffolds in combination with cells and/or soluble factors has emerged as a promising approach in the field of regenerative medicine. A biomaterial serves as a matrix that provides a specific environment to support growth and development. An ideal scaffold must be biocompatible and non-toxic, enhancing cell viability, adhesion, and proliferation.
This Special Issue aims to provide an overview of ongoing scientific research focusing primarily on bone tissue regeneration while also addressing the broader applications involving other tissues, such as cartilage, nerve, and skin regeneration. We seek to highlight innovative aspects of biofunctionalized scaffolds, including their design modifications, the incorporation of mesenchymal stem cells (MSCs) that promote bone regeneration through osteogenic differentiation, and the priming of scaffolds with soluble molecules, including growth factors that perform therapeutic actions.
In addition to these broad themes, we invite submissions that specifically explore the following topics:
- Advances in scaffold fabrication techniques for enhanced biofunctionality;
- The role of MSCs in synergy with biofunctionalized scaffolds for tissue repair;
- Mechanistic studies on cellular responses to biofunctionalized environments;
- Evaluation of scaffold performance in both in vitro and in vivo models;
- Innovative strategies for the delivery of growth factors from scaffolds;
- Clinical translation challenges and opportunities for biofunctionalized scaffolds.
Through this Special Issue, we aim to deepen our understanding of the molecular mechanisms involved in tissue regeneration and evaluate the potential of biofunctionalized scaffolds for future clinical applications. We believe that contributions from various in vitro and/or in vivo studies could significantly impact the development of stem cell-based regeneration strategies and the identification of key biological regulatory processes.
Sincerely,
Dr. Francesca Diomede
Dr. Jacopo Pizzicannella
Guest Editors
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Keywords
- biofunctionalized scaffolds
- regenerative medicine
- biocompatibility
- tissue engineering
- mesenchymal stem cells
- 3D constructs
- cell–biomaterial interactions
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