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Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 3272

Special Issue Editor


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Guest Editor
1. Founder and Director of BioMAT’X R&D&I (HAiDAR I+D+i )LABs, Las Condes, Santiago, Chile
2. Professor and Scientific Director—Research, Development and Innovation, Faculty of Dentistry, Universidad de los Andes, Santiago, Chile
3. Professor, Dental Sciences Doctoral Program, Faculty of Dentistry, Universidad de los Andes, Santiago, Chile
4. Professor, CiiB, BioMedicine Doctoral Program, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
Interests: patient-oriented development and evaluation of bionanotechnology; biopolymers; bioceramics and drug delivery systems for the repair; restoration, reconstruction and regeneration of challenging craniofacial and orthopaedic defects, and beyond
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues.

It is my privilege to invite you to submit a manuscript for an upcoming Special Issue of Materials, entitled “Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine”.

Innovative tissue engineering and regenerative medicine solutions that incorporate nanobiotechnology, advanced biomaterials, computer assistance, three-dimensional printing, and robotic systems offer extensive potential for augmenting and improving the functional and esthetic cranio-maxillo-facial and oro-dental health profile of patients.

A good example, perhaps, is nanodentistry, clearly multidisciplinary and interdisciplinary, building on existing knowledge and accruing expertise in different scientific and technological fields, seeking persistent refinement of traditional approaches, via the development and/or incorporation of advanced functional biomaterials, cell-/gene-/drug-delivery systems, new tools, and pharmacological formulations to improve overall oro-dental practice and care, which is slowly-evolving yet expected to provide dentists with more precision-made and tailored materials, drugs, and equipment, by which safety, esthetics, function, and patient compliance are enhanced. Due to the complex nature of such “outside-the-box” oro-dental and cranio-maxillo-facial (head and neck) healthcare-related engineering technologies, they have attracted experts from physics, chemistry, biology, materials science, pharmaceutics, robotics, and bioengineering, as well as industry.

This Special Issue is dedicated to the state-of-the-art in oro-dental and cranio-maxillo-facial tissue engineering (restoration, replacement, reconstruction, regeneration and repair)-related topics and emphasizes the bionanotechnology-, functional biomaterial-, and three-dimensional-related topics for innovative alternative solution design, characterization, evaluation and optimization. Hence, the focus is on demonstrating physico-chemico-mechanical/rheological, cellular, histomorphometrical and immunohistochemical parameters and safety (cyto-/bio-compatibility) and efficacy (pre-clinical and clinical) characteristics of functional biomaterials for tissue engineering and regenerative medicine.

Through a collection of original papers, this Special Issue aims to exhibit the latest state-of-the-art in R&D&i ideas, concepts, findings, achievements, and future projections and promote awareness of this rapidly-evolving and enabling multidisciplinary technology, thereby encouraging bridging the gap between medicine, dentistry, pharmacy, material sciences and engineering (including sub-specialities, extending to the head and neck, orthopaedics, oncology, amongst others) for research collaboration across the fields to address the critical and urgent bio-dental/bio-medical concerns. Clinicians and researchers are invited to contribute with their original evidence-based articles, as well as critical literature review manuscripts, summarizing the most recent and exciting innovative developments.

Potential topics include, but are not limited to, the following:

  • Biomimetic nanobiomaterials
  • Bioceramics and bioglasses
  • Exosomes and multi-vesicular bodies as drug carriers and delivery vehicles
  • Functional scaffolds for craniomaxillofacial tissue engineering applications
  • Stimuli-responsive biomaterials for tissue engineering
  • Smart and multifunctional biomaterials for tissue engineering
  • Functional biomaterials and cell/tissue–material interactions
  • Natural polymer-based biomaterials for tissue engineering
  • Nanodentistry and the role of nanobiotechnology in biomaterials, pharmaceutics, and biodental tissue engineering
  • Image-guided surgery and medico-dental robotics
  • 3-D printing and surgical engineering in the craniomaxillofacial complex
  • Computer-aided planning and intraoperative navigation in dental implantology and craniomaxillofacial surgery
  • Biomaterial fabrication and evaluation techniques: freeze drying, electrospinning, etc.
  • Drug/Gene delivery and Cell therapy
  • Injectable biomaterials for pharmaceutic agent (cell, gene, drug) delivery
  • Cosmetology and orofacial surgery
  • Microfabrication approaches for engineering functional tissues
  • Platelet concentrates and platelet-rich fibrin for tissue repair
  • Translational functional biomaterials: bench-top to bed-side/market

You may choose our Joint Special Issue in JFB.

Prof. Dr. Ziyad S. Haidar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • tissue engineering
  • regenerative medicine
  • bionanotechnology
  • biopolymers
  • bioceramics
  • drug delivery
  • restoration
  • orthopaedic

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Published Papers (1 paper)

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Research

11 pages, 6591 KiB  
Article
Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses
by Mahfuza Toshmatova, Sentaro Nakanishi, Yukiharu Sugimura, Vera Schmidt, Artur Lichtenberg, Alexander Assmann and Payam Akhyari
Materials 2019, 12(20), 3351; https://doi.org/10.3390/ma12203351 - 15 Oct 2019
Cited by 8 | Viewed by 2506
Abstract
Decellularization of non-autologous biological implants reduces the immune response against foreign tissue. Striving for in vivo repopulation of aortic prostheses with autologous cells, thereby improving the graft biocompatibility, we examined surface coating with laminin in a standardized rat implantation model. Detergent-decellularized aortic grafts [...] Read more.
Decellularization of non-autologous biological implants reduces the immune response against foreign tissue. Striving for in vivo repopulation of aortic prostheses with autologous cells, thereby improving the graft biocompatibility, we examined surface coating with laminin in a standardized rat implantation model. Detergent-decellularized aortic grafts from donor rats (n = 37) were coated with laminin and systemically implanted into Wistar rats. Uncoated implants served as controls. Implant re-colonization and remodeling were examined by scanning electron microscopy (n = 10), histology and immunohistology (n = 18). Laminin coating persisted over eight weeks. Two weeks after implantation, no relevant neoendothelium formation was observed, whereas it was covering the whole grafts after eight weeks, with a significant acceleration in the laminin group (p = 0.0048). Remarkably, the intima-to-media ratio, indicating adverse hyperplasia, was significantly diminished in the laminin group (p = 0.0149). No intergroup difference was detected in terms of medial recellularization (p = 0.2577). Alpha-smooth muscle actin-positive cells originating from the adventitial surface invaded the media in both groups to a similar extent. The amount of calcifying hydroxyapatite deposition in the intima and the media did not differ between the groups. Inflammatory cell markers (CD3 and CD68) proved negative in coated as well as uncoated decellularized implants. The coating of decellularized aortic implants with bioactive laminin caused an acceleration of the autologous recellularization and a reduction of the intima hyperplasia. Thereby, laminin coating seems to be a promising strategy to enhance the biocompatibility of tissue-engineered vascular implants. Full article
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