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Advances in Nanomaterials for Medical Application, Drug Delivery and Bone Tissue Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 4398

Special Issue Editor

Prof. Marco Biondi

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples “Federico II”, via Domenico Montesano 49, 80131 Napoli, Italy
Interests: preparation of micro- and nanoparticles for controlled or targeted drug delivery; pharmaceutical applications of zeolitic materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue, entitled “Advances in Nanomaterials for Medical Application, Drug Delivery and Bone Tissue Engineering”, of Materials will focus on the latest developments in the field of nanomaterials and their applications in medicine. The Special Issue will cover a range of topics, including the use of nanomaterials for drug delivery, tissue engineering, and medical implants. The included articles will explore the potential of these materials to revolutionize healthcare by improving the effectiveness of treatments and reducing side effects. The Special Issue will also highlight the challenges that need to be overcome to fully realize the potential of nanomaterials in medicine, such as biocompatibility and toxicity. Overall, this Special Issue promises to provide a comprehensive overview of state-of-the-art nanomaterials for medical applications and their potential to transform healthcare.

Prof. Marco Biondi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • biocompatibility
  • tissue engineering
  • drug delivery
  • medical implants
  • nanotechnology
  • biodegradability
  • scaffolds
  • stem cells
  • medical imaging

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Published Papers (3 papers)

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Research

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14 pages, 2327 KiB  
Article
Silibinin-Loaded Amphiphilic PLGA–Poloxamer Nanoparticles: Physicochemical Characterization, Release Kinetics, and Bioactivity Evaluation in Lung Cancer Cells
by Fabrizio Villapiano, Miriam Piccioni, Federica D’Aria, Stefania Crispi, Giovanna Rassu, Paolo Giunchedi, Elisabetta Gavini, Concetta Giancola, Carla Serri, Marco Biondi and Laura Mayol
Materials 2024, 17(22), 5480; https://doi.org/10.3390/ma17225480 - 10 Nov 2024
Viewed by 629
Abstract
Despite its potential against several carcinomas, the pharmacological efficacy of silibinin (SLB) is hampered by poor solubility, absorption, and oral bioavailability. To face these issues, we developed polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) coated with hydrophilic polyethene oxide (PEO) for controlled and targeted SLB [...] Read more.
Despite its potential against several carcinomas, the pharmacological efficacy of silibinin (SLB) is hampered by poor solubility, absorption, and oral bioavailability. To face these issues, we developed polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) coated with hydrophilic polyethene oxide (PEO) for controlled and targeted SLB delivery. NPs were produced at two different SLB loadings and presented a spherical shape with smooth surfaces and stable size in water and cell culture medium. The encapsulation efficiencies were found to be >84%, and thermal analysis revealed that the SLB was present in an amorphous state within the NPs. In vitro SLB release experiments revealed that at the lowest SLB loading, desorption of the active molecule from the surface or nanoporosities of the NPs mainly dictates release. In contrast, at the highest SLB loading, diffusion primarily regulates release, with negligible contributions from other mechanisms. Cell experiments showed that, compared with the free drug, SLB loaded in the produced NPs significantly increased the bioactivity against H1299, H1975, and H358 cells. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Medical Application, Drug Delivery and Bone Tissue Engineering)
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21 pages, 15617 KiB  
Article
Combustion Synthesis of Functionalized Carbonated Boron Nitride Nanoparticles and Their Potential Application in Boron Neutron Capture Therapy
by Stanisław Cudziło, Bożena Szermer-Olearnik, Sławomir Dyjak, Mateusz Gratzke, Kamil Sobczak, Anna Wróblewska, Agnieszka Szczygieł, Jagoda Mierzejewska, Katarzyna Węgierek-Ciura, Andrzej Rapak, Paulina Żeliszewska, Dawid Kozień, Zbigniew Pędzich and Elżbieta Pajtasz-Piasecka
Materials 2024, 17(10), 2438; https://doi.org/10.3390/ma17102438 - 18 May 2024
Cited by 1 | Viewed by 998
Abstract
In this research, we developed boron-rich nanoparticles that can be used for boron neutron capture therapy as potential carriers for boron delivery to cancerous tissues. Functionalized carbonated boron nitride nanostructures (CBNs) were successfully synthesized in self-propagating combustion waves in mixtures of high-nitrogen explosives [...] Read more.
In this research, we developed boron-rich nanoparticles that can be used for boron neutron capture therapy as potential carriers for boron delivery to cancerous tissues. Functionalized carbonated boron nitride nanostructures (CBNs) were successfully synthesized in self-propagating combustion waves in mixtures of high-nitrogen explosives and boron compounds. The products’ composition, morphology, and structural features were investigated using Fourier transform infrared spectroscopy, powder X-ray diffraction, low-temperature nitrogen sorption analysis, thermogravimetric analysis, high-resolution scanning electron microscopy, and high-resolution transmission electron microscopy. The extreme conditions prevailing in combustion waves favor the formation of nanosized CBN hollow grains with highly disordered structures that are properly functionalized on the surface and inside the particles. Therefore, they are characterized by high porosity and good dispersibility in water, which are necessary for medical applications. During biological tests, a concentration-dependent effect of the obtained boron nitride preparations on the viability of normal and neoplastic cells was demonstrated. Moreover, the assessment of the degree of binding of fluorescently labeled nanoparticles to selected cells confirmed the relationships between the cell types and the concentration of the preparation at different incubation time points. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Medical Application, Drug Delivery and Bone Tissue Engineering)
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Review

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35 pages, 4279 KiB  
Review
Nano-Innovations in Cancer Therapy: The Unparalleled Potential of MXene Conjugates
by Sanjay Kulkarni, Soji Soman, Prerana D. Navti, Amrita Arup Roy, Ajinkya Nitin Nikam, P. Vineeth, Jahnavi Kulkarni, Krishnaraj Somayaji Shirur, Abhijeet Pandey, Sajan D. George and Srinivas Mutalik
Materials 2024, 17(6), 1423; https://doi.org/10.3390/ma17061423 - 20 Mar 2024
Cited by 4 | Viewed by 2254
Abstract
MXenes are two-dimensional transition metal carbides, nitrides, and carbonitrides that have become important materials in nanotechnology because of their remarkable mechanical, electrical, and thermal characteristics. This review emphasizes how crucial MXene conjugates are for several biomedical applications, especially in the field of cancer. [...] Read more.
MXenes are two-dimensional transition metal carbides, nitrides, and carbonitrides that have become important materials in nanotechnology because of their remarkable mechanical, electrical, and thermal characteristics. This review emphasizes how crucial MXene conjugates are for several biomedical applications, especially in the field of cancer. These two-dimensional (2D) nanoconjugates with photothermal, chemotherapeutic, and photodynamic activities have demonstrated promise for highly effective and noninvasive anticancer therapy. MXene conjugates, with their distinctive optical capabilities, have been employed for bioimaging and biosensing, and their excellent light-to-heat conversion efficiency makes them perfect biocompatible and notably proficient nanoscale agents for photothermal applications. The synthesis and characterization of MXenes provide a framework for an in-depth understanding of various fabrication techniques and their importance in the customized formation of MXene conjugates. The following sections explore MXene-based conjugates for nanotheranostics and demonstrate their enormous potential for biomedical applications. Nanoconjugates, such as polymers, metals, graphene, hydrogels, biomimetics, quantum dots, and radio conjugates, exhibit unique properties that can be used for various therapeutic and diagnostic applications in the field of cancer nanotheranostics. An additional layer of understanding into the safety concerns of MXene nanoconjugates is provided by detailing their toxicity viewpoints. Furthermore, the review concludes by addressing the opportunities and challenges in the clinical translation of MXene-based nanoconjugates, emphasizing their potential in real-world medical practices. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Medical Application, Drug Delivery and Bone Tissue Engineering)
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