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Physico-Chemical Modification of Materials for Biomedical Application
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Physico-Chemical Modification of Materials for Biomedical Application

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 863

Special Issue Editors

Prof. Dr. Bernadeta Dobosz

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Guest Editor
Functional Materials Physics Division, Faculty of Physics, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 2, 61-614 Poznań, Poland
Interests: nanomedicine; biomaterials; electron spin resonance application; biosignals; medical physics
Special Issues, Collections and Topics in MDPI journals
Dr. Joanna Czwartos

E-Mail Website
Guest Editor
Biomedical Engineering Centre, Institute of Optoelectronics, Military University of Technology, 2 Kaliskiego St., 00-908 Warsaw, Poland
Interests: interaction of soft X-ray/extreme ultraviolet (SXR/EUV) radiation and low-temperature plasma with polymers; surface modification; polymeric biomaterials; scaffolds; surface bioactivation; cytocompatibility enhancement; AFM; SEM; XPS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We cordially invite you to contribute to this Special Issue by showcasing your achievements in material modifications for biomedical applications.

Despite the development of technology, new and better solutions that could be used in medicine are still being sought. Various types of materials, including polymers, carbon-based materials, and nanoparticles, are attracting interest for their use in medical diagnostics and therapy.

In this Special Issue, we focus on new ideas and perspectives for material modification methods, such as plasma treatment, exposure to SXR/EUV/UV radiation, laser processing, chemical modification, surface coating, and grafting with nanoparticles. Functionalization with various molecules and drugs in order to improve the effectiveness of disease detection and treatment is also within the scope of this issue.

It is our pleasure to invite you to contribute an original research paper, a short communication, or a review to this issue.

Prof. Dr. Bernadeta Dobosz
Dr. Joanna Czwartos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical modification
  • surface coating
  • functionalization with biomolecules and drugs
  • plasma treatment
  • exposure to SXR/EUV/UV radiation
  • laser processing
  • grafting with nanoparticles
  • polymers
  • carbon materials
  • nanoparticles (metal, lipid, polymer)

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Published Papers (2 papers)

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Research

17 pages, 1743 KiB  
Article
Fabrication and Characterization of Electrospun DegraPol® Tubes Releasing TIMP-1 Protein to Modulate Tendon Healing
by Julia Rieber, Roger Khalid Niederhauser, Pietro Giovanoli and Johanna Buschmann
Materials 2025, 18(3), 665; https://doi.org/10.3390/ma18030665 (registering DOI) - 3 Feb 2025
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Abstract
Background: Tendon rupture repair can result from fibrotic scar formation through imbalanced ECM deposition during remodeling. The tissue inhibitors of matrix metalloprotease (TIMPs) not only decrease ECM degradation, regulated by matrix metalloproteases (MMPs), but also restrict TGF-β1 activation and thus diminish fibrosis. Methods: [...] Read more.
Background: Tendon rupture repair can result from fibrotic scar formation through imbalanced ECM deposition during remodeling. The tissue inhibitors of matrix metalloprotease (TIMPs) not only decrease ECM degradation, regulated by matrix metalloproteases (MMPs), but also restrict TGF-β1 activation and thus diminish fibrosis. Methods: Rabbit tenocytes (rbTenocytes) and rabbit adipose-derived stem cells (rbASCs) were cultivated under different TIMP-1 concentrations. Proliferation and gene expression were assessed. TIMP-1 was incorporated into emulsion electrospun DegraPol® (DP) tubes that were characterized by SEM for fiber thickness, pore size, and wall thickness. Static and dynamic water contact angles, FTIR spectra, and TIMP-1 release kinetics were determined. Results: While the proliferation of rbTenocytes and rbACS was not affected by TIMP-1 supplementation in vitro, the gene expression of Col1A1 was increased in rbTenocytes, the gene expression of ki67 was increased in both cell types, the gene expression of tenomodulin was increased in both cell types at 100 ng/mL TIMP-1, and alkaline phosphatase expression ALP rose significantly in rbASCs. Electrospun TIMP-1/DP fibers had a ~5 μm diameter, a ~10 μm pore size, and a mesh thickness of ~200 μm. TIMP-1/DP meshes were more hydrophilic than pure DP meshes. TIMP-1 was released from the meshes with a sustained release of up to 7 days. Conclusions: TIMP-1/DP tubes may be used to modulate the fibrotic tissue reaction when applied around conventionally sutured tendon ruptures. Full article
(This article belongs to the Special Issue Physico-Chemical Modification of Materials for Biomedical Application)
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21 pages, 9715 KiB  
Article
Effect of Doping Cement Mortar with Triclosan, Hypochlorous Acid, Silver Nanoparticles and Graphene Oxide on Its Mechanical and Biological Properties
by Mikołaj Paciejewski, Agata Lange, Sławomir Jaworski, Marta Kutwin, Aneta Bombalska, Jarosław Siwiński, Klaudia Olkowicz, Jadwiga Mierczyk, Kamila Narojczyk, Zdzisław Bogdanowicz and Barbara Nasiłowska
Materials 2024, 17(24), 6288; https://doi.org/10.3390/ma17246288 - 23 Dec 2024
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Abstract
In order to improve the performance of cement mortar (Portland cement), it was enriched with triclosan, hypochlorous acid, silver nanoparticles and graphene oxide. Cement mortar is used, among other things, to fill the gaps between the tiles of building porcelain stoneware. A number [...] Read more.
In order to improve the performance of cement mortar (Portland cement), it was enriched with triclosan, hypochlorous acid, silver nanoparticles and graphene oxide. Cement mortar is used, among other things, to fill the gaps between the tiles of building porcelain stoneware. A number of structural, mechanical and biological tests were carried out. The structural tests included microscopic analysis and contact angle, reflectance and IR spectra, while the mechanical tests involved static bending and compression testing. These tests showed that the additions of graphene oxide and hypochlorous acid were most beneficial. These additions, although not detected by spectral methods, resulted in a significant increase in contact angle and mechanical properties. Studies of the viability of the bacteria Pseudomonas aeruginosa and Staphylococcus aureus showed that all the additives used resulted in a decrease in viability compared to the undoped cement mortar. There was also a beneficial decrease in the viability of fungi of the genus Fusarium on cement mortar mainly doped with silver nanoparticles. Full article
(This article belongs to the Special Issue Physico-Chemical Modification of Materials for Biomedical Application)
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