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Hydrogels: Preparation, Characterization, and Applications
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Hydrogels: Preparation, Characterization, and Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 5778

Special Issue Editor

Dr. Evangelos Delivopoulos

E-Mail Website
Guest Editor
Biomedical Engineering, School of Biological Sciences, University of Reading, Reading, UK
Interests: hydrogels; alginate; chitosan; agarose; PLGA; collagen; gelatin; Matrigel; hyaluronic acid; PDMS; PEG; differentiation; stem cells; elasticity; porosity; viscosity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels have propelled the field of tissue engineering in the past two decades. Three-dimensional environments encapsulating cells are now being fabricated from natural (animal and plant) and synthetic (polymer and peptide) biomaterials. These scaffolds have adjustable mechanical and chemical properties, while their geometries can be specified with high precision. Therefore, hydrogel platforms can recapitulate the native microenvironment of a variety of tissues and stem cells. Through the hydrogel encapsulation of stem cells and the targeted delivery of growth factors, exciting organoids have been proposed either as research tools or as potentially transplantable, functional organs. From bone repair via biodegradable structures to neural tissue engineering via hybrid platforms, hydrogels are ubiquitous and are revolutionizing medicine. In this Special Issue, we are interested in publishing novel hydrogel formulations and their characterization, fabrication, and assembly techniques, including 3D bioprinting and applications from the research lab to the clinic.  

It is our pleasure to invite you to submit a manuscript for this Special Issue. We welcome the submission of full papers, communications, and reviews.

Dr. Evangelos Delivopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carboxylated agarose
  • alginate hydrogels
  • matrigel
  • gelatin methacryloyl hydrogels (GelMA)
  • electroconductive hydrogels—PEDOT, CMCS
  • decellularized extracellular matrix hydrogels
  • hyaluronic acid hydrogels
  • 3D bioprinting of scaffolds
  • mechanical characterization of scaffolds
  • neural induction of stem cells

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Published Papers (2 papers)

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Research

15 pages, 2461 KiB  
Article
Evaluation of Selected Properties of Sodium Alginate-Based Hydrogel Material—Mechanical Strength, μDIC Analysis and Degradation
by Jagoda Kurowiak, Agnieszka Mackiewicz, Tomasz Klekiel and Romuald Będziński
Materials 2022, 15(3), 1225; https://doi.org/10.3390/ma15031225 - 6 Feb 2022
Cited by 10 | Viewed by 2822
Abstract
The search for ideal solutions for the treatment of urethral stenosis continues. This includes developing the material, design, while maintaining its optimal and desired properties. This paper presents the results of the research conducted on sodium alginate-based hydrogel material (AHM), which may be [...] Read more.
The search for ideal solutions for the treatment of urethral stenosis continues. This includes developing the material, design, while maintaining its optimal and desired properties. This paper presents the results of the research conducted on sodium alginate-based hydrogel material (AHM), which may be used as a material for stents dedicated to the treatment of pathologies occurring in the genitourinary system. In order to determine the selected parameters of the AHM samples, strength and degradation tests, as well as analysis of the micro changes occurring on the surface of the material using a digital image correlation (µDIC) system, were performed. This study shows that the material possessed good mechanical strength parameters, the knowledge of which is particularly important from the point of view of the stent-tissue interaction. The degradation analysis performed showed that the AHM samples degrade in an artificial urine environment, and that the degradation time mainly depends on the chemical composition of the material. The novel µDIC method performed allowed us to characterize the homogeneity of the material structure depending on the cross-linking agent used. Full article
(This article belongs to the Special Issue Hydrogels: Preparation, Characterization, and Applications)
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18 pages, 4904 KiB  
Article
Ce/Sm/Sr-Incorporating Ceramic Scaffolds Obtained via Sol-Gel Route
by Sorin-Ion Jinga, Ana-Maria Anghel, Silvia-Florena Brincoveanu, Raluca-Maria Bucur, Andrei-Dan Florea, Bianca-Irina Saftau, Stefania-Cristina Stroe, Andreea-Ioana Zamfirescu and Cristina Busuioc
Materials 2021, 14(6), 1532; https://doi.org/10.3390/ma14061532 - 21 Mar 2021
Cited by 3 | Viewed by 2148
Abstract
Three different inorganic scaffolds were obtained starting from the oxide system SiO2‒P2O5‒CaO‒MgO, to which Ce4+/Sm3+/Sr2+ cations were added in order to propose novel materials with potential application in the field of hard [...] Read more.
Three different inorganic scaffolds were obtained starting from the oxide system SiO2‒P2O5‒CaO‒MgO, to which Ce4+/Sm3+/Sr2+ cations were added in order to propose novel materials with potential application in the field of hard tissue engineering. Knowing the beneficial effects of each element, improved features in terms of mechanical properties, antibacterial activity and cellular response are expected. The compositions were processed in the form of scaffolds by a common sol-gel method, followed by a thermal treatment at 1000 and 1200 °C. The obtained samples were characterized from thermal, compositional, morphological and mechanical point of view. It was shown that each supplementary component triggers the modification of the crystalline phase composition, as well as microstructural details. Moreover, the shrinkage behavior is well correlated with the attained compression strength values. Sm was proven to be the best choice, since in addition to a superior mechanical resistance, a clear beneficial influence on the viability of 3T3 fibroblast cell line was observed. Full article
(This article belongs to the Special Issue Hydrogels: Preparation, Characterization, and Applications)
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