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Scaffolds for Bone Tissue Engineering II

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 1054

Special Issue Editors


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Guest Editor
Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal
Interests: biocomposites; tissue regeneration; extracellular matrix proteins/peptides; target-molecule delivery systems; antibacterial strategies
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Guest Editor
Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal
Interests: bone regeneration; bone-graft substitutes; calcium-phosphate biomaterials; implant-associated infections; antibacterials

Special Issue Information

Dear Colleagues,

Bone disorders and conditions such as osteoporosis, bone fractures and bone infections are increasing. These are mainly  related to an increase in life expectancy together with obesity and poor physical activity in aging populations.

Bone tissue engineering is one of the most promising strategies for the treatment of patients, as well as for active aging, using a combination of biomaterials, cells and target molecular signals mimicking the bone microenvironment. Several 3D matrices can be applied to induce new functional bone regeneration as ceramic materials, natural polymers, and ceramic- and polymer-based biocomposites. Scaffolds for bone tissue engineering need to comply with several requirements, particularly biocompatibility, osteoconduction and osteoinduction. Moreover, this field is rapidly evolving into new areas of innovation. Particularly, a new generation of bone scaffolds has emerged in the last few years with features for improved regeneration, such as combined levels of porosity (macro-, micro-, and nanoporosity) and immobilized biomolecules. Frequently, this new generation of scaffolds can also function in other simultaneous processes such as vascularization, inflammation and, sometimes, infection. For successful commercialization, these materials should also be easy to handle and implant during surgical procedures, as well as being cost-effective and having reasonable shelf-lives.

Following our nomination as Editors of a Special Issue of the Journal Materials, published by MDPI and dedicated to “Scaffolds for Bone Tissue Engineering”, it is our pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications and reviews are all welcome.

Prof. Dr. Susana R. Sousa
Dr. Catarina C. Coelho
Guest Editors

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Keywords

  • scaffolds
  • bone tissue engineering
  • bone regeneration
  • bone-graft substitutes
  • bone infection
  • antibacterial materials
  • ceramic-based biomaterials

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Published Papers (1 paper)

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24 pages, 3039 KiB  
Systematic Review
Local Antibiotic Delivery Ceramic Bone Substitutes for the Treatment of Infected Bone Cavities and Bone Regeneration: A Systematic Review on What We Have Learned from Animal Models
by Nuno Alegrete, Susana R. Sousa, Bárbara Peleteiro, Fernando J. Monteiro and Manuel Gutierres
Materials 2023, 16(6), 2387; https://doi.org/10.3390/ma16062387 - 16 Mar 2023
Cited by 5 | Viewed by 1645
Abstract
Aims: the focus of this study is to evaluate if the combination of an antibiotic with a ceramic biomaterial is effective in treating osteomyelitis in an infected animal model and to define which model and protocol are best suited for in vivo experiments [...] Read more.
Aims: the focus of this study is to evaluate if the combination of an antibiotic with a ceramic biomaterial is effective in treating osteomyelitis in an infected animal model and to define which model and protocol are best suited for in vivo experiments of local bone infection treatment. Methods: a systematic review was carried out based on PRISMA statement guidelines. A PubMed search was conducted to find original papers on animal models of bone infections using local antibiotic delivery systems with the characteristics of bone substitutes. Articles without a control group, differing from the experimental group only by the addition of antibiotics to the bone substitute, were excluded. Results: a total of 1185 records were retrieved, and after a three-step selection, 34 papers were included. Six manuscripts studied the effect of antibiotic-loaded biomaterials on bone infection prevention. Five articles studied infection in the presence of foreign bodies. In all but one, the combination of an antibiotic with bioceramic bone substitutes tended to prevent or cure bone infection while promoting biomaterial osteointegration. Conclusions: this systematic review shows that the combination of antibiotics with bioceramic bone substitutes may be appropriate to treat bone infection when applied locally. The variability of the animal models, time to develop an infection, antibiotic used, way of carrying and releasing antibiotics, type of ceramic material, and endpoints limits the conclusions on the ideal therapy, enhancing the need for consistent models and guidelines to develop an adequate combination of material and antimicrobial agent leading to an effective human application. Full article
(This article belongs to the Special Issue Scaffolds for Bone Tissue Engineering II)
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