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Smart Nanomaterials: Molecular Design for Advanced Medicine

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 June 2022) | Viewed by 5024

Special Issue Editors


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Guest Editor
Department of Chemical, Materials and Production Engineering (DICMaPI), University of Naples Federico II, p. le V. Tecchio 80, 80125 Naples, Italy
Interests: photocatalysis; nanomaterials synthesis; structure–function relationships; thermo-analytical methodologies; hybrid materials design
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Chemical, Materials and Production Engineering (DICMaPI) University of Naples Federico II Piazzale Tecchio, 80 80125 Napoli, Italy
Interests: nanomaterials synthesis; hybrid materials design, bioinspired multifunctional systems; surface functionalization of nanostructured materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The marriage between nanotechnology and biomaterials science promises to revolutionize medical practice.  Actually, nanomaterials, featuring superior size-tunable properties, high intrinsic reactivity, and sizes comparable with those of functional moieties in biology can establish strong interactions with biological systems, thus triggering key biological events and ultimately driving cells fate.  Materials design at the nanoscale allows fine tuning of their physical-chemical properties, providing unique tools for scientists to unveil biochemical pathways and set up more personalized treatment with enhanced therapeutic efficacy. 

This Special Issue aims to collect theoretical, experimental, and review contributions to show the most recent advances in nanomaterials in medicine as well as the challenges and opportunities provided by the materials design at the nanoscale in the field of biomedical devices.

We commit to providing contributions from leading research groups and from the multidisciplinary community of chemists, physicists, biologists, material scientists and engineers, focusing on molecular design of nanomaterials especially, but not exclusively, in the following areas:

  • Antimicrobial devices
  • Regenerative Medicine
  • Diagnosis and therapy
  • New Imaging Devices
  • Drug-Delivery
  • Tissue Engineering
  • Environmental and toxicity concern

Prof. Dr. Giuseppina Luciani
Prof. Dr. Brigida Silvestri
Guest Editors

Manuscript Submission Information

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Keywords

  • Nanomaterials design and processing
  • Processing-structure-property relationships
  • Surface functionalization of nanostructured materials Tissue Engineering
  • Smart Drug-Delivery
  • Imaging
  • Regenerative medicine
  • Nanotoxicity

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Published Papers (2 papers)

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Research

11 pages, 2430 KiB  
Article
Experimental Investigation on the Bioprotective Role of Trehalose on Glutamine Solutions by Infrared Spectroscopy
by Maria Teresa Caccamo and Salvatore Magazù
Materials 2022, 15(12), 4329; https://doi.org/10.3390/ma15124329 - 18 Jun 2022
Cited by 1 | Viewed by 1691
Abstract
Glutamine plays a significant role in several basic metabolic processes and is an important regulator of heat shock protein response. The present work is focused on the analysis of the thermal response of aqueous solutions of Glutamine and aqueous solutions of Glutamine in [...] Read more.
Glutamine plays a significant role in several basic metabolic processes and is an important regulator of heat shock protein response. The present work is focused on the analysis of the thermal response of aqueous solutions of Glutamine and aqueous solutions of Glutamine in the presence of Trehalose by means of infrared absorption technique. The performed study shows how in the case of a multicomponent system, characterized by a huge number of spectral contributions whose assignment are questionable, the Spectral Distance (SD) and the Cross Wavelet Correlation (XWT) approaches are able to furnish explanatory parameters that can characterize the variations in the spectra behaviour, which is an efficient tool for quantitative comparisons. With this purpose, the analysis has been performed by evaluating the SD and the XWT parameters for the whole investigated spectral range, i.e., 4000–400 cm−1, for scans collected as a function of temperature in the range 20 °C ÷ 60 °C both for Glutamine/Water compounds and for Glutamine /Water/Trehalose mixtures. By means of these analyses, it is found that in aqueous solutions of Glutamine, with respect to aqueous solutions of Glutamine in the presence of Trehalose, the SD and XWT temperature trends follow a linear behaviour where the angular coefficient for Glutamine /Water/Trehalose compounds are lower than that of the Glutamine-Water system in both cases. The obtained findings suggest that Trehalose stabilizes Glutamine against heat treatment. Full article
(This article belongs to the Special Issue Smart Nanomaterials: Molecular Design for Advanced Medicine)
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21 pages, 6050 KiB  
Article
The Mechanisms of Antibacterial Activity of Magnesium Alloys with Extreme Wettability
by Alexandre M. Emelyanenko, Alexander G. Domantovsky, Valery V. Kaminsky, Ivan S. Pytskii, Kirill A. Emelyanenko and Ludmila B. Boinovich
Materials 2021, 14(18), 5454; https://doi.org/10.3390/ma14185454 - 21 Sep 2021
Cited by 16 | Viewed by 2528
Abstract
In this study, we applied the method of nanosecond laser treatment for the fabrication of superhydrophobic and superhydrophilic magnesium-based surfaces with hierarchical roughness when the surface microrelief is evenly decorated by MgO nanoparticles. The comparative to the bare sample behavior of such surfaces [...] Read more.
In this study, we applied the method of nanosecond laser treatment for the fabrication of superhydrophobic and superhydrophilic magnesium-based surfaces with hierarchical roughness when the surface microrelief is evenly decorated by MgO nanoparticles. The comparative to the bare sample behavior of such surfaces with extreme wettability in contact with dispersions of bacteria cells Pseudomonas aeruginosa and Klebsiella pneumoniae in phosphate buffered saline (PBS) was studied. To characterize the bactericidal activity of magnesium samples with different wettability immersed into a bacterial dispersion, we determined the time variation of the planktonic bacterial titer in the dispersion. To explore the anti-bacterial mechanisms of the magnesium substrates, a set of experimental studies on the evolution of the magnesium ion concentration in liquid, pH of the dispersion medium, surface morphology, composition, and wettability was performed. The obtained data made it possible to reveal two mechanisms that, in combination, play a key role in the bacterial decontamination of the liquid. These are the alkalization of the dispersion medium and the collection of bacterial cells by microrods growing on the surface as a result of the interaction of magnesium with the components of the buffer solution. Full article
(This article belongs to the Special Issue Smart Nanomaterials: Molecular Design for Advanced Medicine)
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