Radiotherapy for Brain Metastasis and Long-Term Survival
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1757
Special Issue Editors
Interests: CyberKnife; radiosurgery; SBRT; FSRT; radiotherapy
Special Issues, Collections and Topics in MDPI journals
Interests: neurosurgery; CyberKnife; radiosurgery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Patients with brain metastases can benefit from radiotherapy, although the long‐term benefits of radiotherapy remain unclear. Stereotactic radiosurgery (SRS) improves the local control of brain metastases. Furthermore, the QUARTZ trial revealed that whole-brain radiotherapy (WBRT) provides limited benefits, relative to best supportive care alone, for patients with brain metastases from non-small cell lung cancer. The literature data revealed that poor overall survival after WBRT was associated with poor performance status, older age, >3 intracranial metastases, and uncontrolled primary tumors. Based on these conflicting findings, questions have emerged regarding the benefits of radiotherapy for brain metastases that were determined based on previous clinical studies. The combined evidence suggests that WBRT offers no substantial benefit to most patients with brain metastases from lung cancer in terms of improved survival, overall quality of life, or reduction in steroid use. The implication for clinical care is that optimal supportive care is as effective as supportive care plus WBRT, and the implication for future research is that potential new treatments could be assessed in addition to supportive care, rather than in addition to, or in place of, WBRT. Given the lack of long-term analyses of the benefits of radiotherapy in this setting, it is necessary to compare the long-term results of radiotherapy for brain metastases.
Therefore, we encourage authors to submit their original research articles, reviews, systematic reviews, case reports, clinical outcome studies or new surgical techniques and oncological therapies regarding this subject.
Dr. Antonio Pontoriero
Dr. Alfredo Conti
Guest Editors
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Keywords
- whole-brain irradiation
- stereotactic radiosurgery
- brain metastasis
- median survival
- risk factor and long-term survival
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