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Medicina
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Recent Advances in Cardiac Arrest
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Recent Advances in Cardiac Arrest

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 2853

Special Issue Editor

Dr. Mitsuaki Nishikimi

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Guest Editor
Laboratory for Critical Care Physiology, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030, USA
Interests: cardiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiac arrest (CA) is a significant public health problem, affecting over 60,000 individuals in Japan and over 300,000 individuals in the US each year. Although their survival rates have been improved through updated resuscitation guidelines, their neurological outcomes remain poor, and there many patients have been left in a vegetative state or a coma after CA, even if they successfully achieved a return of spontaneous circulation (ROSC) and received intensive care treatment after CA. So far, numerous clinical trials have attempted to discover novel therapies for improving their neurological outcomes, but no established treatments exist except targeted temperature management, which means we need to further facilitate the research to improve their outcomes.

This Special Issue aims to discuss knowledge gaps and research priorities in the field of resuscitation science for CA, as well as to present potential novel treatment strategies to improve their outcomes. The scope of this Special Issue intentionally encompasses a wide range of topics and perspectives related to the research for CA. This not only includes basic research, but also clinical research, review articles, and case reports related to pre-hospital medicine, extracorporeal cardiopulmonary resuscitation, outcome prediction, pediatric CA, the pathophysiology of CA (particularly brain injury after CA), training/education in resuscitation, as well as pre-, intra-, and post-CA care.

Dr. Mitsuaki Nishikimi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac arrest
  • post-cardiac arrest syndrome
  • brain injury after cardiac arrest
  • resuscitation science

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Published Papers (2 papers)

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Research

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11 pages, 1541 KiB  
Article
Optimal Targeted Temperature Management for Patients with Post-Cardiac Arrest Syndrome
by Tsukasa Yagi, Eizo Tachibana, Wataru Atsumi, Keiichiro Kuronuma, Kazuki Iso, Satoshi Hayashida, Shonosuke Sugai, Yusuke Sasa, Yoshikuni Shoji, Satoshi Kunimoto, Shigemasa Tani, Naoya Matsumoto and Yasuo Okumura
Medicina 2024, 60(10), 1575; https://doi.org/10.3390/medicina60101575 - 25 Sep 2024
Viewed by 853
Abstract
Background: To prevent hypoxic–ischemic brain damage in patients with post-cardiac arrest syndrome (PCAS), international guidelines have emphasized performing targeted temperature management (TTM). However, the most optimal targeted core temperature and cooling duration reached no consensus to date. This study aimed to clarify [...] Read more.
Background: To prevent hypoxic–ischemic brain damage in patients with post-cardiac arrest syndrome (PCAS), international guidelines have emphasized performing targeted temperature management (TTM). However, the most optimal targeted core temperature and cooling duration reached no consensus to date. This study aimed to clarify the optimal targeted core temperature and cooling duration, selected according to the time interval from collapse to return of spontaneous circulation (ROSC) in patients with PCAS due to cardiac etiology. Methods: Between 2014 and 2020, the targeted core temperature was 34 °C or 35 °C, and the cooling duration was 24 h. If the time interval from collapse to ROSC was within 20 min, we performed the 35 °C targeted core temperature (Group A), and, if not, we performed the 34 °C targeted core temperature (Group B). Between 2009 and 2013, the targeted core temperature was 34 °C, and the cooling duration was 24 or 48 h. If the interval was within 20 min, we performed the 24 h cooling duration (Group C), and, if not, we performed the 48 h cooling duration (Group D). Results: The favorable neurological outcome rates at 30 days following cardiac arrest were 45.7% and 45.5% in Groups A + B and C + D, respectively (p = 0.977). In patients with ROSC within 20 min, the favorable neurological outcome rates at 30 days following cardiac arrest were 75.6% and 86.4% in Groups A and C, respectively (p = 0.315). In patients with ROSC ≥ 21 min, the favorable neurological outcome rates at 30 days following cardiac arrest were 29.3% and 18.2% in Groups B and D, respectively (p = 0.233). Conclusions: Selecting the optimal target core temperature and the cooling duration for TTM, according to the time interval from collapse to ROSC, may be helpful in patients with PCAS due to cardiac etiology. Full article
(This article belongs to the Special Issue Recent Advances in Cardiac Arrest)
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Review

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11 pages, 262 KiB  
Review
Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest
by Shu Utsumi, Mitsuaki Nishikimi, Shinichiro Ohshimo and Nobuaki Shime
Medicina 2024, 60(3), 510; https://doi.org/10.3390/medicina60030510 - 21 Mar 2024
Cited by 2 | Viewed by 1498
Abstract
Out-of-hospital cardiac arrest (OHCA) is heterogeneous in terms of etiology and severity. Owing to this heterogeneity, differences in outcome and treatment efficacy have been reported from case to case; however, few reviews have focused on the heterogeneity of OHCA. We conducted a literature [...] Read more.
Out-of-hospital cardiac arrest (OHCA) is heterogeneous in terms of etiology and severity. Owing to this heterogeneity, differences in outcome and treatment efficacy have been reported from case to case; however, few reviews have focused on the heterogeneity of OHCA. We conducted a literature review to identify differences in the prognosis and treatment efficacy in terms of CA-related waveforms (shockable or non-shockable), age (adult or pediatric), and post-CA syndrome severity and to determine the preferred treatment for patients with OHCA to improve outcomes. Full article
(This article belongs to the Special Issue Recent Advances in Cardiac Arrest)
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