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Medicina
Special Issues
Percutaneous Ablation: Hot Topics, Established and Advanced Indications
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Percutaneous Ablation: Hot Topics, Established and Advanced Indications

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (17 May 2023) | Viewed by 7564

Special Issue Editors

Dr. Dimitrios Filippiadis

E-Mail Website
Guest Editor
2nd Department of Radiology, University General Hospital "ATTIKON" Medical School, National and Kapodistrian University of Athens, Athens, Greece
Interests: interventional oncology; ablation; vertebral augmentation; MSK interventions
Special Issues, Collections and Topics in MDPI journals
Dr. Laura Crocetti

E-Mail Website
Guest Editor
1. Division of Interventional Radiology, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
2. Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy
Interests: interventional oncology; liver; ablation; intra-arterial; solid tumors
Special Issues, Collections and Topics in MDPI journals
Dr. Govindarajan Narayanan

E-Mail Website
Guest Editor
1. Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA
2. Miami Cardiac and Vascular, Baptist Health South Florida, Miami, FL 33176, USA
3. Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
Interests: HCC; pancreas cancer; cancer ablation; IRE; mCRC
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Percutaneous ablation constitutes a nonsurgical treatment for various cancers using image guidance. Ablative techniques are minimally invasive procedures which can be used to treat patients with benign or malignant (primary and metastatic) tumors as well as patients who are nonsurgical or poor surgical candidates due to co-morbidities. The percutaneous injection of ethanol was the first reported ablation technique, which was followed by thermal (radiofrequency, laser, microwave and cryoablation) and non-thermal (irreversible electroporation) ablation options. Furthermore, recent innovations contribute to the constant evolution of ablative techniques, and currently, established and advanced indications are governing the clinical practice of ablation for tumor management.

The purpose of this Special Issue is to provide an inside view into different ablation techniques used for the achievement of both curative and palliative goals and to introduce the basic concepts and advancements in the field. It will offer an overview of the different ablation modalities available for tumor management, focusing on advantages and future applications.

This Special Issue welcomes original articles that present experimental and clinical studies as well as reviews of the literature describing the current state of the art.

Potential topics include (but are not limited to):

  • Established and advanced indications of ablative options for local tumor control;
  • Established and advanced palliative indications of ablative options;
  • The efficacy and safety of ablation in tumor management;
  • Simulation, navigation and verification software in ablation;
  • Combination therapies;
  • Ablation and immuno-oncology.

Dr. Dimitrios Filippiadis
Dr. Laura Crocetti
Dr. Govindarajan Narayanan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • interventional oncology
  • ablation
  • ethanol
  • radiofrequency
  • microwave
  • cryoablation
  • irreversible electroporation
  • high-intensity focused ultrasound
  • histotripsy

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Published Papers (4 papers)

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Review

12 pages, 2926 KiB  
Review
Oncologic Outcomes after Percutaneous Ablation for Colorectal Liver Metastases: An Updated Comprehensive Review
by David-Dimitris Chlorogiannis, Vlasios S. Sotirchos and Constantinos T. Sofocleous
Medicina 2024, 60(9), 1536; https://doi.org/10.3390/medicina60091536 - 20 Sep 2024
Viewed by 1230
Abstract
Colorectal cancer is a major cause of cancer-related mortality, with liver metastases occurring in over a third of patients, and is correlated with poor prognosis. Despite surgical resection being the primary treatment option, only about 20% of patients qualify for surgery. Current guidelines [...] Read more.
Colorectal cancer is a major cause of cancer-related mortality, with liver metastases occurring in over a third of patients, and is correlated with poor prognosis. Despite surgical resection being the primary treatment option, only about 20% of patients qualify for surgery. Current guidelines recommend thermal ablation either alone or combined with surgery to treat limited hepatic metastases, provided that all visible disease can be effectively eradicated. Several ablation modalities, including radiofrequency ablation, microwave ablation, cryoablation, irreversible electroporation and histotripsy, are part of the percutaneous ablation armamentarium. Thermal ablation, including radiofrequency, microwave ablation and cryoablation, can offer local tumor control rates comparable to limited resection for selected tumors that can be ablated with margins. This review aims to encapsulate the current clinical evidence regarding the efficacy and oncologic outcomes after percutaneous ablation for the treatment of colorectal liver metastatic disease. Full article
(This article belongs to the Special Issue Percutaneous Ablation: Hot Topics, Established and Advanced Indications)
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19 pages, 3406 KiB  
Review
Irreversible Electroporation of the Hepatobiliary System: Current Utilization and Future Avenues
by Govindarajan Narayanan, Yilun Koethe and Nicole Gentile
Medicina 2024, 60(2), 251; https://doi.org/10.3390/medicina60020251 - 31 Jan 2024
Cited by 1 | Viewed by 1879
Abstract
Liver cancer remains a leading cause of cancer-related deaths worldwide despite numerous advances in treatment. While surgical resection remains the gold standard for curative treatment, it is only possible for a minority of patients. Thermal ablation is an effective option for the treatment [...] Read more.
Liver cancer remains a leading cause of cancer-related deaths worldwide despite numerous advances in treatment. While surgical resection remains the gold standard for curative treatment, it is only possible for a minority of patients. Thermal ablation is an effective option for the treatment of smaller tumors; however, its use is limited to tumors that are not located in proximity to sensitive structures due to the heat sink effect and the potential of thermal damage. Irreversible electroporation (IRE) is a non-thermal ablative modality that can deliver targeted treatment and the effective destruction of tumors that are in close proximity to or even surrounding vascular or biliary ducts with minimal damage to these structures. IRE produces short pulses of high-frequency energy which opens pores in the lipid bilayer of cells leading to apoptosis and cell death. IRE has been utilized clinically for over a decade in the treatment of liver cancers with multiple studies documenting an acceptable safety profile and high efficacy rates. Full article
(This article belongs to the Special Issue Percutaneous Ablation: Hot Topics, Established and Advanced Indications)
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13 pages, 3455 KiB  
Review
Image-Guided Prostate Cryoablation: State-of-the-Art
by Vijay Ramalingam, Colin J. McCarthy, Spencer Degerstedt and Muneeb Ahmed
Medicina 2023, 59(9), 1589; https://doi.org/10.3390/medicina59091589 - 2 Sep 2023
Cited by 1 | Viewed by 1916
Abstract
Image-guided focal therapy has increased in popularity as a treatment option for patients with primary and locally recurrent prostate cancer. This review will cover the basic indications, evaluation, treatment algorithm, and follow-up for patients undergoing image-guided ablation of the prostate. Additionally, this paper [...] Read more.
Image-guided focal therapy has increased in popularity as a treatment option for patients with primary and locally recurrent prostate cancer. This review will cover the basic indications, evaluation, treatment algorithm, and follow-up for patients undergoing image-guided ablation of the prostate. Additionally, this paper will serve as an overview of some technical approaches to cases so that physicians can familiarize themselves with working in this space. While the focus of this paper is prostate cryoablation, readers will obtain a basic literature overview of some of the additional available image-guided treatment modalities for focal prostate therapy. Full article
(This article belongs to the Special Issue Percutaneous Ablation: Hot Topics, Established and Advanced Indications)
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12 pages, 867 KiB  
Review
Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma
by Georgios Charalampopoulos, Roberto Iezzi, Maria Tsitskari, Argyro Mazioti, Olympia Papakonstantinou, Alexis Kelekis, Nikolaos Kelekis and Dimitrios Filippiadis
Medicina 2023, 59(7), 1186; https://doi.org/10.3390/medicina59071186 - 22 Jun 2023
Cited by 3 | Viewed by 1974
Abstract
Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. There is a [...] Read more.
Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. There is a growing literature suggesting percutaneous ablative techniques for the management of patients with iCCA measuring ≤3 cm with contraindications to surgery as well as for recurrent or residual tumors aiming to provide local cancer treatment and control. Most used ablative therapies for iCCA include radiofrequency and microwave ablation with irreversible electroporation, cryoablation and reversible electroporation (electrochemotherapy) being less commonly encountered techniques. Due to the infiltrative margins of the lesion, there is a need for larger safety margins and ablation zone; multi-apparatus ablation or other variations of the technique such as balloon-assisted approaches can be utilized aiming to increase size of the zone of necrosis. The present review paper focuses upon the current role of percutaneous ablative techniques for the therapeutic management of iCCA. The purpose of this review is to present the current minimally invasive ablative techniques in the treatment of iCCA, including local control and survival rates. Full article
(This article belongs to the Special Issue Percutaneous Ablation: Hot Topics, Established and Advanced Indications)
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