Global Perspectives on Sepsis: Epidemiology, Awareness and Treatment Strategies

Dear Colleagues,

Sepsis, a life-threatening condition resulting from a dysregulated host response to infection, has been a significant global health concern for decades. Despite advances in medicine, sepsis continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries. The condition has complex etiologies, making it difficult to diagnose and treat, especially in resource-limited settings. Historical milestones in understanding sepsis include the early recognition of its systemic inflammatory nature and the development of protocols such as the "Surviving Sepsis Campaign." However, the increasing prevalence of antimicrobial resistance and disparities in healthcare delivery have added new dimensions to this age-old challenge, necessitating renewed focus and collaborative global strategies.

This Special Issue, Global Perspectives on Sepsis: Epidemiology, Awareness and Treatment Strategies, will provide a comprehensive platform for discussing the latest developments in sepsis research, prevention, and management. By integrating insights from epidemiological studies, clinical advancements, and public health efforts, this Special Issue will address global disparities in sepsis outcomes and resource allocation. It emphasizes the importance of innovative diagnostic tools, effective treatment protocols, and global awareness campaigns for reducing the burden of sepsis. This Special Issue will serve as a multidisciplinary forum for advancing understanding, fostering collaboration, and shaping policies to improve sepsis care globally.

This Special Issue will feature cutting-edge research that explores novel approaches to diagnosing, treating, and managing sepsis. Topics of interest include the following:

• Development and implementation of biomarkers and rapid diagnostic tools;
• Artificial intelligence and machine learning applications in sepsis prediction and management;
• Innovations in antimicrobial therapies and strategies to combat resistance;
• Insights into the immunopathology and molecular mechanisms of sepsis;
• Advances in personalized medicine, such as precision therapeutics tailored to individual patient profiles;
• Global epidemiological trends, highlighting disparities in incidence, outcomes, and resource availability;
• Evaluation of awareness campaigns and their impacts on early detection and treatment;
• Health systems approaches for improving sepsis care in low-resource settings.

We invite original research articles, reviews, meta-analyses, clinical case studies, and commentaries that align with the following themes:

• Epidemiological studies examining the global and regional burden of sepsis;
• Research on diagnostic innovations, including biomarkers and imaging techniques;
• Studies on treatment protocols, including the use of advanced therapies and supportive care;
• Investigations into the role of antimicrobial resistance in sepsis outcomes;
• Papers highlighting the challenges and successes of awareness campaigns;
• Research on healthcare disparities and access to sepsis care in different regions;
• Contributions on public health policies and interventions for improving sepsis outcomes;
• Translational research bridging basic science findings with clinical applications;
• Perspectives on sepsis management in specialized populations, such as neonates, the elderly, and immunocompromised patients.

Dr. Alice Dragoescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• sepsis
• global health
• treatment strategies
• early diagnosis
• personalized medicine
• immunopathology
• awareness campaigns