Latest Findings in Diagnosis and Treatment of Gynecological Malignancies—2nd Edition

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 1053

Special Issue Editor

Special Issue Information

Dear Colleagues,

Gynecological cancers still represent one of the leading causes of female death around the world. Nevertheless, the mortality and morbidity of these diseases have been on a downward trend in recent years, thanks to technological advances in surgery, oncology, and palliative care.

This Special Issue was created with the intention of collecting the latest findings in the scientific field that may refine a clinical practice or clarify the “grey areas” still present in the scientific literature. This Special Issue comes in the light of major and groundbreaking scientific discoveries that have revolutionized the approach to major gynecologic oncologic diseases, such as the LACC trial by Ramirez, which questioned the appropriateness of minimally invasive approaches in the surgical treatment of cervical carcinoma, or the SOLO-1 Trial, which introduced the use of PARP-Inhibitors for the treatment of ovarian carcinomas, opening up new scenarios still to be explored today. In addition, the increasing spread of robotic surgery, as well as the refinement of laparoscopic instruments, offer new technical horizons previously difficult to imagine. Further, the growing knowledge regarding the molecular signature of gynecological cancer and radio diagnostic advantages offers physicians the opportunity to diagnose and treat gynecological cancer early and personalize treatment. Finally, a not insignificant aspect in the management of gynecologic oncology patients is the important scientific progress that has occurred with the application of ERAS protocols and the optimization of palliative care. The scientific community is experiencing a very prosperous period that is resulting in a steady improvement in clinical care. Our Special Issue was created to collect the latest findings in these areas. We, therefore, invite our authors to contribute their most important testimonials in the form of case reports, original articles, review articles, and meta-analyses.

Dr. Stefano Cianci
Guest Editor

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Keywords

  • gynecologic oncology
  • gynecological surgery
  • cancer treatment
  • cancer diagnosis

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Published Papers (1 paper)

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Review

15 pages, 717 KiB  
Review
New Insights into the Assessment of Peri-Operative Risk in Women Undergoing Surgery for Gynecological Neoplasms: A Call for a New Tool
by Alfred-Dieter Krutsch, Cristina Tudoran and Alexandru Catalin Motofelea
Medicina 2024, 60(10), 1679; https://doi.org/10.3390/medicina60101679 - 13 Oct 2024
Viewed by 732
Abstract
Existing tools for predicting postoperative complications in women undergoing surgery for gynecological neoplasms are evaluated in this narrative review. Although surgery is a very efficient therapy for gynecological tumors, it is not devoid of the possibility of negative postoperative outcomes. Widely used tools [...] Read more.
Existing tools for predicting postoperative complications in women undergoing surgery for gynecological neoplasms are evaluated in this narrative review. Although surgery is a very efficient therapy for gynecological tumors, it is not devoid of the possibility of negative postoperative outcomes. Widely used tools at present, such as the Surgical Apgar Score and the Modified Frailty Index, fail to consider the complex characteristics of gynecological malignancies and their related risk factors. A thorough search of the PubMed database was conducted for our review, specifically targeting studies that investigate several aspects impacting postoperative outcomes, including nutritional status, obesity, albumin levels, sodium levels, fluid management, and psychological well-being. Research has shown that both malnutrition and obesity have a substantial impact on postoperative mortality and morbidity. Diminished sodium and albumin levels together with compromised psychological well-being can serve as reliable indicators of negative consequences. The role of appropriate fluid management in enhancing patient recovery was also investigated. The evidence indicates that although current mechanisms are useful, they have limitations in terms of their range and do not thoroughly address these recently identified risk factors. Therefore, there is a need for a new, more comprehensive tool that combines these developing elements to more accurately forecast postoperative problems and enhance patient results in gynecological oncology. This paper highlights the need to create such a tool to improve clinical practice and the treatment of patients. Full article
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