Impact of Anesthetics on Cancer Behavior and Outcome
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 6645
Special Issue Editors
Interests: regional anesthesia; peri and postoperative pain; cancer recurrence
Special Issue Information
Dear Colleagues,
Background and history of this topic: Clinical and basic science studies have demonstrated the antiinflammatory properties of local anesthetics. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. The potential beneficial effects of regional anesthesia have been attributed mainly to the inhibition of the neuroendocrine stress response to surgery and to the reduction in the requirements of volatile anesthetics and opioids. Because cancer is linked to inflammation and local anesthetics have anti-inflammatory effects, these agents may participate in reducing the risk of metastasis, buth their mechanism of action is unknown. We demonstrated in vitro that amide local anesthetics attenuate tumor cell migration as well as signaling pathways enhancing tumor growth and metastasis. This has provided the first evidence of a molecular mechanism by which regional anesthesia might inhibit or reduce cancer metastases.
Aim and scope of the special issue: To summarize the most recent evidence of how drugs used in anesthesia can or cannot influence cancer behavior and outcome
Cutting edge research: This issue will collect and display the biomolecular and gene expression findings associated with the infusion of local anesthetics in this context.
Dr. Alain Borgeat
Dr. Jose A. Aguirre
Guest Editors
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Keywords
- local anesthetics
- cancer behavior
- biomolecular mechanisms
- gene expression
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