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Medicina
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Current Advancements in Menopause Treatment and Management
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Current Advancements in Menopause Treatment and Management

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 6618

Special Issue Editor

Dr. Richa Sood

E-Mail Website
Guest Editor
Menopause and Women’s Sexual Health Clinic, General Internal Medicine, Mayo Clinic, Rochester, MN, USA
Interests: menopause; hormone therapy; genitourinary syndrome of menopause; female sexual dysfunction; female pelvic floor dysfunction; resilience; mindfulness

Special Issue Information

Dear Colleagues,

Menopause, a by-product of longer human lifespans, can be a very challenging experience for some as it is often accompanied by the occurrence of vasomotor symptoms, sleep disturbance, vaginal dryness, and sexual dysfunction; 85 percent of women experience at least one of the symptoms which affects their quality of life. A greater concern is that 1 in 2 women develop osteoporosis later in menopause, and menopausal hormonal changes increase women’s risk of cardiovascular disease.

Fortunately, the last few years have witnessed a significant transformation in how we approach menopausal care. Three impactful changes shaping menopausal medicine are better information dissemination, innovation in drug development, and integration of artificial intelligence. Rapid growth in information access and open communications are helping to normalize the menopausal experience and empowering women to make informed choices. The recent movement towards more equitable and democratized care is likely to expand this progress globally.

Innovation in drug development using computer-aided drug designs have resulted in more precise contender molecules and drugs. The recent approval of the neurokinin-3 receptor antagonist Fezolinetant for vasomotor symptoms is one such example of innovation positively impacting menopausal medicine.

Despite all such progress, many questions still remain unanswered. Can we predict who will have sustained debilitating hot flashes? Who will experience a premature menopause? We hope that these questions, and many more, could be answered in the coming years using machine learning and artificial intelligence as they have the potential to analyze large volumes of data, and eventually personalize menopause management.

In this context, we cordially invite scholars and experts to contribute their original research, review articles or meta-analyses to this Special Issue, ‘Current Advancements in Menopause Treatment and Management’.

Dr. Richa Sood
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • menopause
  • vasomotor symptoms
  • hormone therapy
  • tele-medicine
  • drug innovation
  • machine learning
  • artificial intelligence
  • cardiovascular
  • osteoporosis

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Published Papers (3 papers)

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Research

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10 pages, 684 KiB  
Article
DXA Android-to-Gynoid Ratio and Cardiovascular Risk Assessment in Age and BMI Propensity-Matched Early Postmenopausal Women
by Irina Manuela Nistor, Simona Fica, Sorina Carmen Martin, Theodor Mustata, Theodor Eugen Oprea, Anca Elena Sirbu and Carmen Gabriela Barbu
Medicina 2024, 60(7), 1096; https://doi.org/10.3390/medicina60071096 - 4 Jul 2024
Cited by 1 | Viewed by 2009
Abstract
Background and Objectives: The literature suggests that physiological menopause (MP) seems linked with increased adiposity with a preference for intra-abdominal fat accumulation, greater than what can be attributed only by aging, which could magnify this period’s increased cardiovascular risk. Materials and Methods [...] Read more.
Background and Objectives: The literature suggests that physiological menopause (MP) seems linked with increased adiposity with a preference for intra-abdominal fat accumulation, greater than what can be attributed only by aging, which could magnify this period’s increased cardiovascular risk. Materials and Methods: We retrospectively analyzed two age and body mass index (BMI) propensity-matched subgroups each formed of 90 clinically healthy, 40–60-year-old postmenopausal women, within the first 5 and 5–10 years of MP. The 10-year ASCVD risk was assessed using medical history, anthropometric data, and lipid profile blood tests. The android-to-gynoid (A/G) ratio was computed using Lunar osteodensitometry lumbar spine and hip scans. Results: The A/G ratio was significantly higher for the subgroup evaluated in years 5–10 of MP than in the first 5 years of MP, even after controlling for BMI (1.05 vs. 0.99, p = 0.005). While displaying a significant negative correlation with HDL cholesterol (r = 0.406), the A/G ratio also had positive correlations with systolic blood pressure (BP) values (r = 0.273), triglycerides (r = 0.367), and 10-year ASCVD risk (r = 0.277). After adjusting for smoking, hypertension treatment, and type 2 diabetes, the 10-year ASCVD risk became significantly different for women in the first 5 years (3.28%) compared to those in years 5–10 of MP (3.74%), p = 0.047. Conclusions: In women with similar age and BMI, the A/G ratio appears to vary based on the number of years since menopause onset and correlates with either independent cardiovascular risk parameters like BP, triglycerides, and HDL cholesterol or with composite scores, such as 10-year ASCVD risk. Full article
(This article belongs to the Special Issue Current Advancements in Menopause Treatment and Management)
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Review

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17 pages, 1071 KiB  
Review
Navigating the Proteomic Landscape of Menopause: A Review
by Basant E. Katamesh, Pragyat Futela, Ann Vincent, Bright Thilagar, Mary Whipple, Abdul Rhman Hassan, Mohamed Abuelazm, Sanjeev Nanda, Christopher Anstine and Abhinav Singla
Medicina 2024, 60(9), 1473; https://doi.org/10.3390/medicina60091473 - 9 Sep 2024
Viewed by 1499
Abstract
Background and Objectives: Proteomics encompasses the exploration of protein composition, regulation, function, and pathways. Its influence spans diverse clinical fields and holds promise in addressing various women’s health conditions, including cancers, osteoporosis, and cardiovascular disorders. However, no comprehensive summary of proteomics and [...] Read more.
Background and Objectives: Proteomics encompasses the exploration of protein composition, regulation, function, and pathways. Its influence spans diverse clinical fields and holds promise in addressing various women’s health conditions, including cancers, osteoporosis, and cardiovascular disorders. However, no comprehensive summary of proteomics and menopausal health exists. Our objective was to summarize proteomic profiles associated with diseases and disorders in peri- and postmenopausal women. Materials and Methods: We conducted a comprehensive search of databases including PubMed, Google Scholar, the Cochrane database, Elsevier, and ScienceDirect until 2022. A total of 253 studies were identified, and 41 studies met the inclusion criteria to identify data of interest. These included the study design, disease, and proteomics/proteins of significance, as described by the authors. Results: The 41 studies covered diverse areas, including bone disorders (10 studies), cardiovascular diseases (5 studies), oncological malignancies (10 studies), and various conditions, such as obesity, nonalcoholic liver disease, the effects of hormone replacement therapy, and neurological diseases (16 studies). The results of our study indicate that proteomic profiles correlate with heart disease in peri- and postmenopausal women, with distinct sex differences. Furthermore, proteomic profiles significantly differ between women with and without osteoporosis. Additionally, patients with breast, ovarian, and endometrial cancer exhibit notable variations in proteomic profiles compared to those without these conditions. Conclusions: Proteomics has the potential to enhance risk assessment and disease monitoring in peri- and postmenopausal women. By analyzing unique protein profiles, clinicians can identify individuals with heightened susceptibility to specific diseases or those already affected by established conditions. This review suggests that there is sufficient preliminary data related to proteomics in peri- and postmenopausal women for early identification of cardiovascular disease, osteoporosis, and cancers, disease monitoring, and tailoring individualized therapies. Rigorous validation studies involving large populations are essential before drawing definitive conclusions regarding the clinical applicability of proteomic findings. Full article
(This article belongs to the Special Issue Current Advancements in Menopause Treatment and Management)
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16 pages, 600 KiB  
Review
Clinical Management of Endometriosis in Menopause: A Narrative Review
by Dhruva Dave, Heidi E. Page and Aakriti R. Carrubba
Medicina 2024, 60(8), 1341; https://doi.org/10.3390/medicina60081341 - 18 Aug 2024
Viewed by 2406
Abstract
Endometriosis, an inflammatory disease primarily affecting the pelvis and peritoneum, manifests with pelvic pain, dysmenorrhea, dyschezia, dyspareunia, and infertility. Despite its ubiquity, the management of endometriosis is challenging due to its heterogeneous presentation, limitations in diagnostic methods, variable therapeutic responses, and personal and [...] Read more.
Endometriosis, an inflammatory disease primarily affecting the pelvis and peritoneum, manifests with pelvic pain, dysmenorrhea, dyschezia, dyspareunia, and infertility. Despite its ubiquity, the management of endometriosis is challenging due to its heterogeneous presentation, limitations in diagnostic methods, variable therapeutic responses, and personal and socio-cultural impact on quality of life. This review attempts to consolidate the current literature on endometriosis occurring during and beyond menopause, and to present details regarding management strategies that take into account individual outcomes and goals when managing this condition. The topics included in this review are the clinical features and differential diagnosis of pelvic pain in postmenopausal patients, imaging considerations, serum and laboratory biomarkers, indications for surgery, the principles of hormone replacement therapy, the de novo development of endometriosis after menopause, and malignant transformation. Each topic includes a summary of the current literature, utilizing clinical research, case reports, and expert opinion. Despite a better understanding of the impact of endometriosis beyond menopause, there are many limitations to this condition, specifically with regard to cancer risk and indications for surgery. The existing evidence supports the use of shared decision making and the incorporation of patient preferences in guiding clinical management. Future research endeavors must shed light on the natural history of postmenopausal endometriosis through longitudinal studies in order to foster a deeper understanding of its complicated disease course across women’s lifespans. Full article
(This article belongs to the Special Issue Current Advancements in Menopause Treatment and Management)
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