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Medicina
Special Issues
Medical Developments for Male Reproductive and Urinary Cancer
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Medical Developments for Male Reproductive and Urinary Cancer

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 1911

Special Issue Editors

Dr. Jakub Kła̧cz

E-Mail Website
Guest Editor
1. Department of Urology, Neo Hospital, Krakow, Poland
2. Department of Urology, INVICTA Fertility and Reproductive Center, Gdansk, Poland
Interests: urology; prostate cancer; kidney cancer, bladder cancer; urethral cancer; testicular cancer; male infertility; urinary incontinence; erectile dysfunction; robotic surgical treatment; reconstructive urology; artificial urinary sphincter; penile prosthesis
Dr. Piotr Wierzbicki

E-Mail Website
Guest Editor
Department of Histology, Gdanski Uniwersytet Medyczny, Gdańsk, Poland
Interests: biochemistry & molecular biology; cell biology; oncology; research & experimental medicine; gastroenterology & hepatology
Dr. Tomasz Władysław Konecki

E-Mail Website
Guest Editor
1st Clinic of Urology, Medical University of Lodz, Lodz, Poland
Interests: urology; bladder cancer; prostate cancer; robotic surgical treatment

Special Issue Information

Dear Colleagues,

Cancers of the male reproductive and the urinary system are diseases of increasing prevalence, the treatment of which are undergoing a continuous process of evolution. The characteristic feature of these tumors is that in the majority they remain asymptomatic until they are locally advanced or metastasized. Many of these tumors are still a major problem for oncological urology as well as systemic oncological treatment. Therefore, the development of new technologies, surgical instruments, and surgical methods as well as the implementation of new therapies remain an unsatisfied need of modern urological oncology.

This Special Issue aims to discuss new approaches to male reproductive and urinary system cancers. We prefer original research and review papers concerning progress in Medical Developments for Male Reproductive and Urinary Cancer.

Dr. Jakub Kła̧cz
Dr. Piotr Wierzbicki
Dr. Tomasz Władysław Konecki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • urinary cancers
  • kidney cancer
  • ureteral cancer
  • bladder cancer
  • urethral cancer
  • urothelial cancer
  • penile cancer
  • testicular cancer
  • robotic surgical treatment
  • reconstructive urology
  • phalloplasty
  • male incontinence
  • targeted therapy

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Published Papers (1 paper)

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8 pages, 743 KiB  
Brief Report
Pro-Inflammatory Cytokine Gene Expression in Penile Cancer: Preliminary Studies
by Mateusz Czajkowski, Piotr M. Wierzbicki, Anna Kotulak-Chrząszcz, Bartosz Małkiewicz, Roman Sosnowski, Zbigniew Kmieć and Marcin Matuszewski
Medicina 2023, 59(9), 1623; https://doi.org/10.3390/medicina59091623 - 8 Sep 2023
Viewed by 1591
Abstract
Background and Objectives: Penile cancer is a rare neoplasm in developed countries with an incidence of 0.8/100,000 per male inhabitant. Despite the development of personalized medicine and multimodal treatment, the outcome of penile cancer treatment is insufficient. Our study aimed to assess the [...] Read more.
Background and Objectives: Penile cancer is a rare neoplasm in developed countries with an incidence of 0.8/100,000 per male inhabitant. Despite the development of personalized medicine and multimodal treatment, the outcome of penile cancer treatment is insufficient. Our study aimed to assess the levels of pro-inflammatory cytokines’ mRNA such as interleukin 1-A (encoded by IL1A gene, alias IL-1A), interleukin 1-B (IL1B, IL-1B), interleukin 1 receptor antagonist (IL1RN, IL-1RN), interleukin 6 (IL6, IL-6), transforming growth factor β1 (TGFB1, TGFβ-1), and Interferon-gamma (INFG, INF-γ) in penile cancer tissue and associate them with tumor progression and patient survival. Material and Methods: Skin biopsies from patients suffering from penile cancer (n = 6) and unchanged foreskin from 13 healthy adult males undergoing circumcision due to a short frenulum were obtained. Pro-inflammatory cytokine mRNA levels were quantified through qPCR. Results: We observed higher expression of pro-inflammatory cytokine genes (IL-1A, IL-1B, IL-6, INF-γ, TGF-β) in penile cancer tissue. The average follow-up period was 48 months (range: 38–54 months), during which only one penile tumor progression was observed However, this was without association with the nature of tumor (patient refused radical treatment). Conclusions: This is the first study to show increased expression of cytokines such as IL-1A, IL-1B, IL-6, INF-γ, and TGF-β in penile cancer with positive correlation between TNM staging and INF-γ levels in tumor samples (rs = 0.672, p = 0.045), which may be associated with the immunosuppressive role of the tumor environment. Full article
(This article belongs to the Special Issue Medical Developments for Male Reproductive and Urinary Cancer)
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