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Membranes
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Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity,...
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Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Membrane Applications".

Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 43748

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special Issue Editors

Prof. Dr. Andrzej Lewenstam

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Guest Editor
1. Faculty of Materials Science and Ceramics, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Kraków, Poland
2. Johan Gadolin Process Chemistry Centre, c/o Centre for Process Analytical Chemistry and Sensor Technology (ProSens), Åbo Akademi University, Biskopsgatan 8, 20500 Åbo-Turku, Finland
Interests: sensor technology; electroanalysis; analytical/clinical chemistry; ion-selective electrodes; ion-sensor architectures; membranes and electroactive materials for ion-sensors
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Krzysztof Dołowy

E-Mail Website
Guest Editor
Department of Biophysics, Warsaw University of Life Sciences – SGGW, 159 Nowoursynowska St., 02-776 Warsaw, Poland
Interests: biological membranes; ion channels and transporters; epithelial transport of ions and water; mitochondria bioelectrochemistry; sensors; microfluidic systems; mathematical modeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ion-sensors, conventionally known as ion-selective membrane electrodes, were founded a hundred years ago by the invention of a pH electrode with a glass membrane (in 1906 Cremer, in 1909 Haber and Klemensiewicz). That electrode type had a symmetric design with an internal contact made by a solution.

Today there are many membranes made of glass, solid-state, plastics, and composites, as well numerous internal contacts made of conducting polymers, carbon nanotubes, graphene, conducting clays, and composites. For this reason, the sensors can be miniaturized; made service-free; and produced by a mass fabrication technique, such as 3D printing. Responses are now treated by models that are able to the access time-and-space domains of the sensors. Supported by advanced modeling, the ion-sensors are now deliberately calibration-free, and they may undergo automatic quality check. The sensors can act in ad hoc and routine applications theaters, hospitals, sports, water control, etc.

The heart of the ion-sensors is always the same: a membrane that is able to develop the ion-response due to selective, fast, and reversible ion-exchange at the sample–membrane interface. The membrane can be artificial or biological. 

The aim of this Special Issue is to present novel waves and to show the progress that has been made recently in ion-sensor technology. All aspects that contribute to successful advancements of the design, understanding, and application of ion-sensors are of interest. I look forward to receiving your contributions. The submission site is ready to receive your contributions to sensors science.

Prof. Andrzej Lewenstam
Prof. Krzysztof Dołowy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Ion-sensor architectures
  • Membranes and electroactive materials for ion-sensors
  • New fabrication schemes
  • Response interpretation and modeling
  • New applications: wearable, disposable, remotely controlled ion-sensors
  • Routine ion-sensors application

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Related Special Issue

Published Papers (8 papers)

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Editorial

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5 pages, 201 KiB  
Editorial
Special Issue “Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs, and Applications for Ion Measurement”
by Andrzej Lewenstam and Krzysztof Dołowy
Membranes 2020, 10(12), 427; https://doi.org/10.3390/membranes10120427 - 15 Dec 2020
Cited by 3 | Viewed by 1930
Abstract
Ion sensors, conventionally known as ion-selective membrane electrodes, were devised 100 years ago with the invention of a pH electrode with a glass membrane (in 1906 Cremer, in 1909 Haber and Klemensiewicz) [...] Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)

Research

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17 pages, 7686 KiB  
Article
Plasticized PVC Membrane Modified Electrodes: Voltammetry of Highly Hydrophobic Compounds
by Ernő Lindner, Marcin Guzinski, Bradford Pendley and Edward Chaum
Membranes 2020, 10(9), 202; https://doi.org/10.3390/membranes10090202 - 27 Aug 2020
Cited by 11 | Viewed by 4941
Abstract
In the last 50 years, plasticized polyvinyl chloride (PVC) membranes have gained unique importance in chemical sensor development. Originally, these membranes separated two solutions in conventional ion-selective electrodes. Later, the same membranes were applied over a variety of supporting electrodes and used in [...] Read more.
In the last 50 years, plasticized polyvinyl chloride (PVC) membranes have gained unique importance in chemical sensor development. Originally, these membranes separated two solutions in conventional ion-selective electrodes. Later, the same membranes were applied over a variety of supporting electrodes and used in both potentiometric and voltammetric measurements of ions and electrically charged molecules. The focus of this paper is to demonstrate the utility of the plasticized PVC membrane modified working electrode for the voltammetric measurement of highly lipophilic molecules. The plasticized PVC membrane prevents electrode fouling, extends the detection limit of the voltammetric methods to sub-micromolar concentrations, and minimizes interference by electrochemically active hydrophilic analytes. Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)
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18 pages, 3374 KiB  
Article
Optimization of Ruthenium Dioxide Solid Contact in Ion-Selective Electrodes
by Nikola Lenar, Beata Paczosa-Bator and Robert Piech
Membranes 2020, 10(8), 182; https://doi.org/10.3390/membranes10080182 - 9 Aug 2020
Cited by 20 | Viewed by 3123
Abstract
Ruthenium dioxide occurs in two morphologically varied structures: anhydrous and hydrous form; both of them were studied in the scope of this work and applied as mediation layers in ion-selective electrodes. The differences between the electrochemical properties of those two materials underlie their [...] Read more.
Ruthenium dioxide occurs in two morphologically varied structures: anhydrous and hydrous form; both of them were studied in the scope of this work and applied as mediation layers in ion-selective electrodes. The differences between the electrochemical properties of those two materials underlie their diverse structure and hydration properties, which was demonstrated in the paper. One of the main differences is the occurrence of structural water in RuO2•xH2O, which creates a large inner surface available for ion transport and was shown to be a favorable feature in the context of designing potentiometric sensors. Both materials were examined with SEM microscope, X-ray diffractometer, and contact angle microscope, and the results revealed that the hydrous form can be characterized as a porous structure with a smaller crystallite size and more hydrophobic properties contrary to the anhydrous form. Potentiometric and electrochemical tests carried out on designed GCD/RuO2/K+-ISM and GCD/RuO2•xH2O/K+-ISM electrodes proved that the loose porous microstructure with chemically bounded water, which is characteristic for the hydrous form, ensures the high electrical capacitance of electrodes (up to 1.2 mF) with consequently more stable potential (with the potential drift of 0.0015 mV/h) and a faster response (of a few seconds). Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)
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29 pages, 2738 KiB  
Article
Precipitation of Inorganic Salts in Mitochondrial Matrix
by Jerzy J. Jasielec, Robert Filipek, Krzysztof Dołowy and Andrzej Lewenstam
Membranes 2020, 10(5), 81; https://doi.org/10.3390/membranes10050081 - 27 Apr 2020
Cited by 10 | Viewed by 6853
Abstract
In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. [...] Read more.
In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and, hence, can contribute in maintaining ATP production in ischemic conditions, which delays irreversible damage to heart and brain cells after stroke. Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)
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13 pages, 6597 KiB  
Article
Measurement of Multi Ion Transport through Human Bronchial Epithelial Cell Line Provides an Insight into the Mechanism of Defective Water Transport in Cystic Fibrosis
by Miroslaw Zajac, Andrzej Lewenstam, Piotr Bednarczyk and Krzysztof Dolowy
Membranes 2020, 10(3), 43; https://doi.org/10.3390/membranes10030043 - 12 Mar 2020
Cited by 9 | Viewed by 4411
Abstract
We measured concentration changes of sodium, potassium, chloride ions, pH and the transepithelial potential difference by means of ion-selective electrodes, which were placed on both sides of a human bronchial epithelial 16HBE14σ cell line grown on a porous support in the presence of [...] Read more.
We measured concentration changes of sodium, potassium, chloride ions, pH and the transepithelial potential difference by means of ion-selective electrodes, which were placed on both sides of a human bronchial epithelial 16HBE14σ cell line grown on a porous support in the presence of ion channel blockers. We found that, in the isosmotic transepithelial concentration gradient of either sodium or chloride ions, there is an electroneutral transport of the isosmotic solution of sodium chloride in both directions across the cell monolayer. The transepithelial potential difference is below 3 mV. Potassium and pH change plays a minor role in ion transport. Based on our measurements, we hypothesize that in a healthy bronchial epithelium, there is a dynamic balance between water absorption and secretion. Water absorption is caused by the action of two exchangers, Na/H and Cl/HCO3, secreting weakly dissociated carbonic acid in exchange for well dissociated NaCl and water. The water secretion phase is triggered by an apical low volume-dependent factor opening the Cystic Fibrosis Transmembrane Regulator CFTR channel and secreting anions that are accompanied by paracellular sodium and water transport. Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)
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22 pages, 2616 KiB  
Article
Reference Electrodes with Polymer-Based Membranes—Comprehensive Performance Characteristics
by Peter Lingenfelter, Bartosz Bartoszewicz, Jan Migdalski, Tomasz Sokalski, Mirosław M. Bućko, Robert Filipek and Andrzej Lewenstam
Membranes 2019, 9(12), 161; https://doi.org/10.3390/membranes9120161 - 29 Nov 2019
Cited by 22 | Viewed by 6793
Abstract
Several types of liquid membrane and solid-state reference electrodes based on different plastics were fabricated. In the membranes studied, equitransferent organic (QB) and inorganic salts (KCl) are dispersed in polyvinyl chloride (PVC), polyurethane (PU), urea-formaldehyde resin (UF), polyvinyl acetate (PVA), as well as [...] Read more.
Several types of liquid membrane and solid-state reference electrodes based on different plastics were fabricated. In the membranes studied, equitransferent organic (QB) and inorganic salts (KCl) are dispersed in polyvinyl chloride (PVC), polyurethane (PU), urea-formaldehyde resin (UF), polyvinyl acetate (PVA), as well as remelted KCl in order to show the matrix impact on the reference membranes’ behavior. The comparison of potentiometic performance was made using specially designed standardized testing protocols. A problem in the reference electrode research and literature has been a lack of standardized testing, which leads to difficulties in comparing different types, qualities, and properties of reference electrodes. Herein, several protocols were developed to test the electrodes’ performance with respect to stability over time, pH sensitivity, ionic strength, and various ionic species. All of the prepared reference electrodes performed well in at least some respect and would be suitable for certain applications as described in the text. Most of the reference types, however, demonstrated some weakness that had not been previously highlighted in the literature, due in large part to the lack of exhaustive and/or consistent testing protocols. Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)
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Review

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14 pages, 593 KiB  
Review
Unintended Changes of Ion-Selective Membranes Composition—Origin and Effect on Analytical Performance
by Krzysztof Maksymiuk, Emilia Stelmach and Agata Michalska
Membranes 2020, 10(10), 266; https://doi.org/10.3390/membranes10100266 - 28 Sep 2020
Cited by 28 | Viewed by 3994
Abstract
Ion-selective membranes, as used in potentiometric sensors, are mixtures of a few important constituents in a carefully balanced proportion. The changes of composition of the ion-selective membrane, both qualitative and quantitative, affect the analytical performance of sensors. Different constructions and materials applied to [...] Read more.
Ion-selective membranes, as used in potentiometric sensors, are mixtures of a few important constituents in a carefully balanced proportion. The changes of composition of the ion-selective membrane, both qualitative and quantitative, affect the analytical performance of sensors. Different constructions and materials applied to improve sensors result in specific conditions of membrane formation, in consequence, potentially can result in uncontrolled modification of the membrane composition. Clearly, these effects need to be considered, especially if preparation of miniaturized, potentially disposable internal-solution free sensors is considered. Furthermore, membrane composition changes can occur during the normal operation of sensors—accumulation of species as well as release need to be taken into account, regardless of the construction of sensors used. Issues related to spontaneous changes of membrane composition that can occur during sensor construction, pre-treatment and their operation, seem to be underestimated in the subject literature. The aim of this work is to summarize available data related to potentiometric sensors and highlight the effects that can potentially be important also for other sensors using ion-selective membranes, e.g., optodes or voltammetric sensors. Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)
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24 pages, 14297 KiB  
Review
Solid-Contact Ion-Selective Electrodes: Response Mechanisms, Transducer Materials and Wearable Sensors
by Yan Lyu, Shiyu Gan, Yu Bao, Lijie Zhong, Jianan Xu, Wei Wang, Zhenbang Liu, Yingming Ma, Guifu Yang and Li Niu
Membranes 2020, 10(6), 128; https://doi.org/10.3390/membranes10060128 - 23 Jun 2020
Cited by 100 | Viewed by 10827
Abstract
Wearable sensors based on solid-contact ion-selective electrodes (SC-ISEs) are currently attracting intensive attention in monitoring human health conditions through real-time and non-invasive analysis of ions in biological fluids. SC-ISEs have gone through a revolution with improvements in potential stability and reproducibility. The introduction [...] Read more.
Wearable sensors based on solid-contact ion-selective electrodes (SC-ISEs) are currently attracting intensive attention in monitoring human health conditions through real-time and non-invasive analysis of ions in biological fluids. SC-ISEs have gone through a revolution with improvements in potential stability and reproducibility. The introduction of new transducing materials, the understanding of theoretical potentiometric responses, and wearable applications greatly facilitate SC-ISEs. We review recent advances in SC-ISEs including the response mechanism (redox capacitance and electric-double-layer capacitance mechanisms) and crucial solid transducer materials (conducting polymers, carbon and other nanomaterials) and applications in wearable sensors. At the end of the review we illustrate the existing challenges and prospects for future SC-ISEs. We expect this review to provide readers with a general picture of SC-ISEs and appeal to further establishing protocols for evaluating SC-ISEs and accelerating commercial wearable sensors for clinical diagnosis and family practice. Full article
(This article belongs to the Special Issue Advances in Artificial and Biological Membranes: Mechanisms of Ionic Sensitivity, Ion-Sensor Designs and Applications for Ions Measurement)
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