Signaling Pathways Interplay and Crosstalk with Metabolism in Cancer: Where We Stand and Future Perspectives
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 293
Special Issue Editors
Interests: signaling pathways; saliva; oral biocompatibility; periodontal disease; burns; cancer cells metabolism; metabolic reprogramming; autoimmune diseases
Interests: dental biochemistry; oxidative stress in systemic and oral diseases; salivary biomarkers; AKT/mTOR signaling pathway; molecular and biochemical aspects in burns
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer cell survival and growth have been shown to be supported by metabolic alterations. Thus, in the 21st century, one of the major breakthroughs in cancer research was the dispel of the idea that cancer is a purely cell-intrinsic disorder resulting from epigenetic or genetic alterations. Likewise, it is now acknowledged that mitochondrial metabolism plays a vital role not only in all stages of oncogenesis, but in the response to treatment as well. Mutations in oncogenes and tumor suppressors determine how most tumor cells reprogram their metabolism, resulting in the activation of signaling pathways essential in cell proliferation. Moreover, various signaling pathways have been linked to the phenotypic changes associated with malignancies, promoting invasion and metastasis.
Metabolic reprogramming is not a new concept, being recognized as a hallmark of cancer for over a century but, in the context of the crosstalk with the signaling mechanisms involved in tumorigenesis, could provide patients with interesting and novel therapeutic opportunities.
The molecular aspects of the interplay between signaling pathways and the crosstalk with metabolism in cancer cells will be highlighted in this Special Issue, which aims to emphasize the importance of metabolism reprogramming and to present future perspectives in the molecular targeted therapy of cancers. Both original research and review articles are encouraged.
Dr. Iulia-Ioana Stanescu-Spinu
Prof. Dr. Maria Greabu
Guest Editors
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Keywords
- signaling pathways
- cancer cells metabolism
- metabolic reprogramming
- molecular targeted cancer therapy
- metabolomics
- biomarkers
- oxidative stress
- lipid metabolism
- glucose metabolism
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