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Metabolites
Special Issues
Metabolic Biomarkers in Type 2 Diabetes: From Discovery to Application
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Metabolic Biomarkers in Type 2 Diabetes: From Discovery to Application

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 2 April 2025 | Viewed by 1190

Special Issue Editors

Dr. Eiji Kutoh

E-Mail Website
Guest Editor
Biomedical Center, Tokyo 132-0034, Japan
Interests: type 2 diabetes; insulin resistance; molecular endocrinology
Dr. Shengshuai Shan

E-Mail Website
Guest Editor
Clinical and Experimental Therapeutics, University of Georgia, Augusta, GA 30912, USA
Interests: metabolism; metabolic disorder; metabolic biomarkers; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic biomarkers provide valuable insights into the underlying pathophysiology and mechanisms of type 2 diabetes (T2DM). Recent research has identified several key biomarkers associated with glucose metabolism, insulin resistance, and lipid profiles. These biomarkers play a crucial role in:

  1. Accurate diagnosis of T2DM in the early stages.
  2. Predicting disease progression and the risk of complications.
  3. Evaluating treatment responses and identifying individuals who may benefit from personalized interventions.
  4. Understanding the underlying pathophysiology of T2DM and identifying potential therapeutic targets.

Given the rapid advancements in biomarker research, there is an urgent need to translate these discoveries into clinical practice. This Special Issue seeks to address this gap by inviting submissions that explore the discovery, validation, and application of metabolic biomarkers in T2DM. We welcome original research articles, reviews, and case studies that focus on:

  • The identification and validation of novel metabolic biomarkers.
  • The use of biomarkers in predicting disease progression and therapeutic responses.
  • Clinical trials evaluating biomarker-driven personalized treatment strategies.
  • The integration of biomarkers into routine clinical practice and their impact on patient outcomes.

The rationale for this Special Issue is to bridge the current gap between research and practice, facilitating a deeper understanding of T2DM and improving patient care through the effective use of metabolic biomarkers. Despite their potential, challenges such as the validation of biomarkers and their integration into daily clinical practice still require further work. Collaboration between physicians, scientists, and healthcare providers is essential to overcoming these hurdles and advancing the field.

This Special Issue aims to provide a platform for disseminating cutting-edge research and fostering collaboration across disciplines, ultimately contributing to improved management and understanding of T2DM.

Dr. Eiji Kutoh
Dr. Shengshuai Shan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic biomarkers
  • type 2 diabetes (T2DM)
  • glucose metabolism
  • insulin resistance
  • lipid profiles
  • diagnosis and prognosis

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Published Papers (1 paper)

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Research

15 pages, 1179 KiB  
Article
A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response in People with Type 2 Diabetes and Overweight or Obesity
by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten and Odd Erik Johansen
Metabolites 2025, 15(1), 61; https://doi.org/10.3390/metabo15010061 - 16 Jan 2025
Viewed by 625
Abstract
Purpose: Whey protein (WP) consumption prior to a meal curbs appetite and reduces postprandial glucose (PPG) through stimulating endogenous GLP-1 secretion and insulin. Methods: We assessed the metabolic effects of a concentrated WP, using a new micelle-technology (WPM), in people with [...] Read more.
Purpose: Whey protein (WP) consumption prior to a meal curbs appetite and reduces postprandial glucose (PPG) through stimulating endogenous GLP-1 secretion and insulin. Methods: We assessed the metabolic effects of a concentrated WP, using a new micelle-technology (WPM), in people with type 2 diabetes (T2D) and overweight or obesity (NCT04639726). In a randomized-crossover design, participants performed two 240 min lunch meal (622 kcal) tests 7 ± 4 days apart. After an overnight fast and a standardized breakfast, 10 g (125 mL) WPM (40 kcal) or placebo (125 mL water, 0 kcal) was consumed 15 min ahead of the mixed-nutrient meal. Effects on PPG (primary endpoint), insulin, GLP-1, and branched-chain amino acids (BCAAs) were evaluated with frequent blood sampling. Changes in incremental areas under the concentration curve (iAUC) were compared using a mixed model. Results: Twenty-six individuals (14 females, mean ± SD age 62.0 ± 8.3 years, HbA1c 58 ± 12 mmol/mol/7.5 ± 1.1%, BMI 29.2 ± 4.8 kg/m2) completed both tests. WPM significantly reduced PPG iAUC0–2h by 22% (p = 0.028), and iAUC0–3h numerically by −18% (p = 0.090) vs. placebo. WPM also increased insulin iAUC0–1h by 61% (p < 0.001), and iAUC0–3h by 30% (p = 0.004), respectively. Total GLP-1 iAUC0–2h was enhanced by 66% (p < 0.001). Postprandial plasma BCAA patterns were characterized by a rapid increase and larger iAUC0–2h (all p < 0.001) after WPM. No adverse events were ascribed to consuming WPM. Conclusions: A 125 mL pre-meal drink containing just 10 g WPM before a mixed meal reduced PPG and increased insulin, GLP-1, and BCAAs. WPM may therefore serve as a metabolic modulator in people with T2D living with overweight or obesity. Full article
(This article belongs to the Special Issue Metabolic Biomarkers in Type 2 Diabetes: From Discovery to Application)
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