Metabolomics Studies in Ruminant Models: Unraveling Nutritional Physiology and Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1353

Special Issue Editors


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Guest Editor
Section for Ruminants, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
Interests: metabolism; production diseases; ruminants; diagnostics
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Guest Editor
Department of Veterinary medicine, Faculty of Agriculture, University of Novi Sad, 21000 Novi Sad, Serbia
Interests: ruminant metabolism; clinical pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the application of metabolomics in ruminant models to elucidate the intricate relationships between nutrition, physiology, and health. Metabolomics, the comprehensive analysis of metabolites in biological systems, offers a powerful tool to understand how dietary interventions and nutritional status influence metabolic pathways and physiological processes in ruminants.

Scope:

The scope of this Special Issue encompasses a broad range of studies that utilize metabolomic approaches to investigate various aspects of ruminant health and nutrition. We invite original research articles, reviews, and case studies that explore:

  1. The impact of different diets and feed supplements on the metabolic profiles of ruminants.
  2. Metabolic biomarkers associated with health, disease, and productivity in ruminants.
  3. The physiological responses of ruminants to nutritional stressors and their implications for health and disease management.
  4. Innovations in metabolomic techniques and their applications in ruminant nutrition and health studies.
  5. Comparative metabolomic studies between different ruminant species or breeds.

Purpose:

The primary purpose of this Special Issue is to provide a comprehensive platform for advancing our understanding of how nutritional interventions affect ruminant health and physiology at the metabolic level. By showcasing cutting-edge research and innovative methodologies, we aim to highlight the potential of metabolomics in identifying biomarkers for nutritional status, health, and disease in ruminants. Further, we would like to promote the development of targeted nutritional strategies to improve ruminant health and productivity. Finally, our purpose is also to foster interdisciplinary collaborations among researchers in the fields of metabolomics, nutrition, physiology, and veterinary science.

This Special Issue aims to serve as a valuable resource for researchers, veterinarians, and nutritionists seeking to leverage metabolomic insights to enhance ruminant health and well-being. Through the contributions of leading experts and emerging scholars, we strive to unravel the complex interactions between diet, metabolism, and health in ruminant models, ultimately contributing to more sustainable and efficient livestock production systems.

Prof. Dr. Jože Starič
Prof. Dr. Marko R. Cincovic
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • feed supplements
  • metabolic profiles
  • metabolic biomarkers
  • metabolic stress
  • metabolomics

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Published Papers (1 paper)

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Research

14 pages, 771 KiB  
Article
The Impact of Negative Energy Balance in Holstein-Friesian Cows on the Blood Concentrations of Interleukin-6 and Plasminogen
by Kalina Wnorowska, Krzysztof Młynek and Kamila Puppel
Metabolites 2024, 14(10), 548; https://doi.org/10.3390/metabo14100548 - 14 Oct 2024
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Abstract
Background/Objectives: The negative energy balance activaties of spontaneous lipolysis. This may promotes inflammation within the adipose tissue. The aim of the study was to explain the development of inflammation during increased lactogenesis. It was hypothesized that lipolysis contributes synthesis of interleukin-6 and plasminogen. [...] Read more.
Background/Objectives: The negative energy balance activaties of spontaneous lipolysis. This may promotes inflammation within the adipose tissue. The aim of the study was to explain the development of inflammation during increased lactogenesis. It was hypothesized that lipolysis contributes synthesis of interleukin-6 and plasminogen. Methods: The study was in production conditions carried out using Holstein-Friesian cows. The period studied covered time of early lactation. Results: Up to the peak of lactation, milk yield strongly influenced the rate of loss of body condition. This had an impact on with the intensity of the release of the fatty acids. In both cases this relationships strengthened to the peak of production. Oobserved tendencies towards a decrease in the concentration of glucose and an increase in that of leptin. Loss of the body condition and the release of NEFA were were influencing to affect the blood concentrations of interleukin-6 and plasminogen. We have shown that IL-6 has a relatively strong correlation with the NEFA. They correlate with IL-6 independently of EB influence. This may suggest independent associations between these variables, which could potentially be applied in practice. Conclusions: The NEFA release in the long term can increase the inflammatory response within adipose tissue and can intensify the release of interleukin-6 and plasminogen. It is likely that in the initial stage of lactogenesis, the inflammatory process developing within adipose tissue is physiologically justified. Our results can provide background to this little-described area of research. Full article
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