Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 1609

Special Issue Editors


E-Mail Website
Guest Editor
Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo 03828-000, Brazil
Interests: inflammation; nutrigenomics; nutrigenetics; obesity; exercise; protein metabolism; fatty acid metabolism.

E-Mail Website
Guest Editor
Facultad de Medicina y Psicología, Universidad Autónoma Baja California, Tijuana 22390, Mexico
Interests: functional foods; nutrition; exercise physiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases comprise a growing group of disorders associated with inherited and acquired errors in critical enzymes controlling metabolic pathways and homeostatic processes in health. The development of these diseases is widely recognized as being highly linked to fetal development conditions, an individual’s nutritional status, altered endocrine responses, and dietary factors. In this context, “Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases” aims to delve into the physiological factors and mechanisms that may regulate an individual towards a reduced risk of highly prevalent metabolic diseases (such as obesity, fatty liver disease, cancer, hypertension, and/or diabetes), with a particular emphasis on bioactive compounds or food metabolites that positively regulate specific processes.

The scope of this Special Issue focuses on disseminating the scientific community’s advances related to the analysis of bioactives and their metabolites, as well as the regulation of pathways or processes in metabolic disturbances. Researchers seek to uncover potential interventions or preventive measures against metabolic diseases by exploring the roles of bioactive components derived from food sources.

Prof. Dr. Marcelo Macedo Rogero
Dr. Marco Antonio Hernández-Lepe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolism
  • diseases
  • bioactive compounds
  • food
  • metabolites

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

10 pages, 489 KiB  
Article
Oral Supplementation with Betaine Powder Ameliorated High Blood Pressure in Spontaneously Hypertensive Rats
by Samanthi Wathsala Pelpolage, Rie Sasaki, Kenichiro Shimada, Taizo Nagura, Hirokatsu Uchino, Kyu-Ho Han and Michihiro Fukushima
Metabolites 2024, 14(7), 390; https://doi.org/10.3390/metabo14070390 - 18 Jul 2024
Viewed by 1280
Abstract
Supplementation of betaine is associated with improved cardiac health, potentially due to its function in re-methylation of homocysteine, an independent risk factor for cardiovascular diseases. We investigated the effects of oral betaine supplementation on blood pressure homeostasis in spontaneously hypertensive (SHR) rats and [...] Read more.
Supplementation of betaine is associated with improved cardiac health, potentially due to its function in re-methylation of homocysteine, an independent risk factor for cardiovascular diseases. We investigated the effects of oral betaine supplementation on blood pressure homeostasis in spontaneously hypertensive (SHR) rats and Wistar Kyoto (WKY) rats in an 8 week-feeding trial with control (SHR-con and WKY-con) and 1% betaine supplemented (SHR-b and WKY-b) diets. Systolic, diastolic, and mean blood pressure in the SHR-b group were significantly lower at week 8 (p = 0.013, p = 0.011, p = 0.010, respectively). Furthermore, serum nitric oxide (NO) levels were significantly (p < 0.05) improved in the WKY-b and SHR-b groups, suggesting a healthy endothelial function. Additionally, the serum angiotensin I converting enzyme level in SHR-b rats was also significantly lowered, which may have been another reason for lower blood pressure. A significantly higher non-HDL level in the SHR-b group might reflect enhanced lipid secretion into the circulation in the form of very-low-density lipoprotein (VLDL). Betaine is known for its effect on the synthesis of phosphatidylcholine, a key component of VLDL. However, the long-term net outcomes of both blood pressure lowering and serum lipid increment should be further studied. Full article
Show Figures

Figure 1

Back to TopTop