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Metabolites
Special Issues
Animal Intestinal Health and Metabolic Diseases
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Animal Intestinal Health and Metabolic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 5960

Special Issue Editor

Dr. Yiwei Ma

E-Mail Website
Guest Editor
Department of Food Science and Nutrition, University of Minnesota Twin Cities, Minneapolis, MN 55108, USA
Interests: nutrition; metabolomics; animal metabolism

Special Issue Information

Dear Colleagues,

Maintaining and enhancing intestinal health is essential for improving the welfare, productivity, and sustainability of the animal industry today, especially in regions aiming to reduce antibiotic and zinc use.

The bacterial ecosystem (microbiota) living in animals’ intestines plays a crucial role in maintaining the structural integrity of the gut mucosal layer and imparting host nutrient metabolism. Consequently, an imbalanced microbiota causes dysbiosis, undermines the intestinal defense system, and leads to a causal factor of various metabolic diseases. Considering the influence of gut microbiota on the occurrence, development, and consequences of metabolic diseases, it is important to understand the factors influencing gut microbiota and its metabolites to identify strategies to improve intestinal health and prevent metabolic diseases—for example, nutritional interventions.

The aim of this Special Issue is to advance this field by collecting cutting-edge findings on intestinal health and metabolic disease and to identify practical strategies for prevention and treatment. Original recent research findings, reviews, communications, and opinions are all welcome.

Dr. Yiwei Ma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intestinal health
  • gut microbiota
  • metabolic diseases
  • metabolites
  • nutrition
  • antibiotic

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Published Papers (2 papers)

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Research

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15 pages, 9399 KiB  
Article
In Vitro Evaluation of Intestinal Transport and High-Density Fermentation of Lactobacillus acidophilus
by Xin Su, Bilige Menghe, Heping Zhang and Wenjun Liu
Metabolites 2023, 13(10), 1077; https://doi.org/10.3390/metabo13101077 - 13 Oct 2023
Cited by 2 | Viewed by 1544
Abstract
Lactobacillus acidophilus strains have limiting factors such as low cell density and complex nutritional requirements in industrial production, which greatly restricts their industrial application. In this study, fermentation conditions for L. acidophilus were optimized and transcriptomic analysis used to understand growth mechanisms under [...] Read more.
Lactobacillus acidophilus strains have limiting factors such as low cell density and complex nutritional requirements in industrial production, which greatly restricts their industrial application. In this study, fermentation conditions for L. acidophilus were optimized and transcriptomic analysis used to understand growth mechanisms under high-density fermentation conditions. We found that L. acidophilus IMAU81186 has strong tolerance to gastrointestinal juice. In addition, its optimal culture conditions were 3% inoculum (v/v); culture temperature 37 °C; initial pH 6.5; and medium composition of 30.18 g/L glucose, 37.35 g/L soybean peptone, 18.68 g/L fish peptone, 2.46 g/L sodium citrate, 6.125 g/L sodium acetate, 2.46 g/L K2HPO4, 0.4 g/L MgSO4·7H2O,0.04 g/L MnSO4·5H2O, 0.01 g/L serine, and 0.3 g/L uracil. After optimization, viable counts of IMAU81186 increased by 7.03 times. Differentially expressed genes in IMAU81186 were analyzed at different growth stages using transcriptomics. We found that a single carbon source had limitations in improving the biomass of the strain, and terP and bfrA were significantly down-regulated in the logarithmic growth period, which may be due to the lack of extracellular sucrose. After optimizing the carbon source, we found that adding 12 g/L sucrose to the culture medium significantly increased cell density. Full article
(This article belongs to the Special Issue Animal Intestinal Health and Metabolic Diseases)
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Review

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16 pages, 1323 KiB  
Review
The Kidney–Gut Axis as a Novel Target for Nutritional Intervention to Counteract Chronic Kidney Disease Progression
by Sandra Cabała, Małgorzata Ożgo and Agnieszka Herosimczyk
Metabolites 2024, 14(1), 78; https://doi.org/10.3390/metabo14010078 - 22 Jan 2024
Cited by 6 | Viewed by 3325
Abstract
A well-balanced diet is integral for overall health, aiding in managing key risk factors for kidney damage like hypertension while supplying necessary precursors for metabolite production. Dietary choices directly influence the composition and metabolic patterns of the gut microbiota, showing promise as therapeutic [...] Read more.
A well-balanced diet is integral for overall health, aiding in managing key risk factors for kidney damage like hypertension while supplying necessary precursors for metabolite production. Dietary choices directly influence the composition and metabolic patterns of the gut microbiota, showing promise as therapeutic tools for addressing various health conditions, including chronic kidney diseases (CKD). CKD pathogenesis involves a decline in the glomerular filtration rate and the retention of nitrogen waste, fostering gut dysbiosis and the excessive production of bacterial metabolites. These metabolites act as uremic toxins, contributing to inflammation, oxidative stress, and tissue remodeling in the kidneys. Dietary interventions hold significance in reducing oxidative stress and inflammation, potentially slowing CKD progression. Functional ingredients, nutrients, and nephroprotective phytoconstituents could modulate inflammatory pathways or impact the gut mucosa. The “gut–kidney axis” underscores the impact of gut microbes and their metabolites on health and disease, with dysbiosis serving as a triggering event in several diseases, including CKD. This review provides a comprehensive overview, focusing on the gut–liver axis, and explores well-established bioactive substances as well as specific, less-known nutraceuticals showing promise in supporting kidney health and positively influencing CKD progression. Full article
(This article belongs to the Special Issue Animal Intestinal Health and Metabolic Diseases)
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