Metabolic Disorders in Chronic Obstructive Pulmonary Disease and Atherosclerosis
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".
Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 4857
Special Issue Editors
Interests: COPD; respiratory diseases; atherosclerosis; lipid metabolism, lipid transport, inflammation; innate immune system
Special Issue Information
Dear Colleagues,
COPD is one of the most important problems in respiratory medicine. The disease demonstrates adverse trends in prevalence, as well as in its impact on quality of life and prognosis. In turn, the clinical significance of atherosclerosis is emphasized by the heavy medical, economic and social burden on patients, society and health care systems in many countries. It is important to note that COPD and atherosclerosis often occur in the same patient, and in most cases, it is impossible to determine exactly which one developed first. The diseases are often diagnosed in an untimely manner and mutually worsen each other's course, affecting the patient’s quality of life and prognosis. These and other data draw clinicians’ and researchers’ attention to the comorbid course of COPD and atherosclerosis.
A growing amount of evidence suggests an immune and metabolic axis that links COPD and atherosclerosis in their comorbid development and course. Metabolic dysregulation is one of the most important links in the complex chain of processes underlying the pathogenesis of both COPD and atherosclerosis. Immunometabolic switching of immune cells is an important part of inflammation in both COPD and atherosclerosis. It should be noted that the key to understanding many links in the pathogenesis of both isolated and comorbid courses of COPD and atherosclerosis is still largely unknown by clinicians and researchers.
Thus, this Special Issue focuses on original research and thorough reviews of recent advances concerning the metabolic and immune mechanisms underlying COPD and atherosclerosis. These articles can focus on various research aspects that will help to improve the understanding of the metabolic links and their pathophysiological and clinical significance.
Dr. Stanislav Kotlyarov
Dr. Xiaoyan Zhang
Guest Editors
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Keywords
- COPD
- atherosclerosis
- comorbidity
- metabolism
- innate immune system
- inflammation
- immunometabolism
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