Metabolic Pathways of Nutrition Intake in Obese Children

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 7 April 2025 | Viewed by 1568

Special Issue Editors


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Guest Editor
Institute of Health Sciences, Medical College of Rzeszów University, Rzeszów, Poland
Interests: children and adolescents; nutrition; obesity; physical activity; public health
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Institute of Health Sciences, Medical College of Rzeszów University, Rzeszów, Poland
Interests: nutrition; epidemiology; obesity; diet; children
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Institute of Health Sciences, Medical College of Rzeszów University, Rzeszów, Poland
Interests: health promotion; physical activity; public health; nutrition; obesity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Childhood obesity has become a worldwide epidemic in both the developed and developing world. Increased body mass index (BMI) and childhood obesity have significant long-term consequences, including an increased risk of developing chronic diseases such as type 2 diabetes (T2D) and cardiovascular disease (CVD), as well as impaired mental health, social, and economic outcomes. Elucidating the mechanisms of development of childhood obesity at the molecular level may contribute to identifying potential targeted intervention approaches to prevent childhood obesity and clarify the links between obesity and metabolic disease. Many dietary patterns are implicated in the pathway to childhood obesity, either as protective ones, such as the Mediterranean diet pattern, or as harmful ones, such as the Western-type diet pattern. Finally, nutrient intake in the context of childhood obesity could be impaired due to unhealthy eating patterns, and specific nutrients could be lacking in the diets of overweight or obese children. This could result in nutrient deficiencies that could have a harmful effect on their health.

Nutrition is a key part of the imbalance in energy intake and energy expenditure that, through complicated and poorly understood pathways, results in obesity. Metabolic pathways are highly coordinated and regulated to meet the body’s energy requirements throughout the day and night, and they provide molecules required for tissue growth and maintenance. When nutrients are plentiful, anabolic processes build up stores (glycogen and fats) which can be used catabolically to generate energy when nutrients are scarce. High-energy molecules generated by the oxidation of nutrients (carbohydrates, proteins, and fats) are used as an energy source for processes such as active transport and muscle contraction. The aim of this Special Issue of Metabolites is to highlight new insights into the complex role that nutrition plays in the etiology of childhood obesity.

Dr. Edyta Łuszczki
Dr. Katarzyna Dereń
Dr. Anna Bartosiewicz
Guest Editors

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Keywords

  • children and adolescents
  • dietary habits
  • Mediterranean diet
  • metabolic pathways
  • metabolic diseases
  • nutrition
  • obesity
  • Western-type diet

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Published Papers (1 paper)

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Review

20 pages, 1159 KiB  
Review
The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity
by Edyta Łuszczki, Justyna Wyszyńska, Agnieszka Dymek, Dorota Drożdż, Laura González-Ramos, Isa Hartgring, Nuria García-Carbonell, Artur Mazur, Serap Erdine, Justė Parnarauskienė and Julio Alvarez-Pitti
Metabolites 2024, 14(12), 655; https://doi.org/10.3390/metabo14120655 - 25 Nov 2024
Viewed by 1112
Abstract
Background/Objectives: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including [...] Read more.
Background/Objectives: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including depression and low self-esteem. Although the etiology of obesity is complex, research suggests that the diet and lifestyle of pregnant women play a key role in shaping metabolic and epigenetic changes that can increase the risk of obesity in their children. Excessive gestational weight gain, unhealthy dietary patterns (including the Western diet), and pregnancy complications (such as gestational diabetes) are some of the modifiable factors that contribute to childhood obesity. The purpose of this narrative review is to summarize the most important and recent information on the impact of the diet and lifestyle of pregnant women on the risk of childhood obesity. Methods: This article is a narrative review that aims to summarize the available literature on the impact of pregnant women’s diet and lifestyle on the risk of obesity in their offspring, with a focus on metabolic and epigenetic mechanisms. Results/Conclusions: Current evidence suggests that a pregnant woman’s lifestyle and diet can significantly contribute to lowering the risk of obesity in their offspring. However, further high-quality research is needed to understand better the metabolic and epigenetic relationships concerning maternal factors that predispose offspring to obesity. Full article
(This article belongs to the Special Issue Metabolic Pathways of Nutrition Intake in Obese Children)
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