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Regulation and Effect of Sulfur-Containing Amino Acids and Sulfur Compounds...
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Regulation and Effect of Sulfur-Containing Amino Acids and Sulfur Compounds on Metabolism 2nd Edition

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 8991

Special Issue Editors

Dr. Teruo Miyazaki

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Guest Editor
Ibaraki Medical Center, Tokyo Medical University, Tokyo 160-8402, Japan
Interests: energy metabolism; exercise; skeletal muscle; biochemistry; amino acids
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Takashi Ito

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Guest Editor
Faculty of Biotechnology, Fukui Prefectural University, Fukui, Japan
Interests: taurine; food factor; aging
Special Issues, Collections and Topics in MDPI journals
Dr. Alessia Baseggio Conrado

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Guest Editor
National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
Interests: sulfur natural compound; oxidative stress; antioxidants; phototoxicity; food allergy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Shigeru Murakami

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Guest Editor
Faculty of Biotechnology, Fukui Prefectural University, Fukui, Japan
Interests: obesity; diabetes; hepatic steatosis; lipid metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the first volume of this special issue on “Regulation and Effect of Taurine on Metabolism”, the newest insights of taurine (2-aminoethanesulfonic acid) in various fields of nutrition, sport and exercise science, neuroscience, basic medicine, marine science were presented. Taurine is the end product in the metabolic pathway of sulfur-containing amino acids; methionine and cysteine that play essential and important roles on maintenance of cellular system. The sulfur-containing amino acids as well as its derivatives and metabolites have the physiological and pharmacological functions on healthy conditions, preventing various diseases, and supporting growth and aging. The second volume of this special issue welcome researchers to submit original research, review articles, and basic and clinical data in wide fields focusing on not only taurine and its metabolites (hypotaurine, thiotaurine, N-acetyltaurine, N-methyltaurine, tauropine, taurine-conjugated bile acids) but also the common sulfur-containing amino acids (methionine and cysteine), its derivatives and metabolites (S-adenosylmethionine, homocysteine, N-acetylcysteine, S-allylcysteine, S-propylcysteine, S-adenosylhomocysteine), as well as sulfur compounds such as hydrogen sulfide and carbonyl sulfide.

Dr. Teruo Miyazaki
Prof. Dr. Takashi Ito
Dr. Alessia Baseggio Conrado
Prof. Dr. Shigeru Murakami
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolism
  • metabolites
  • in vivo study
  • in vitro study
  • taurine, its tderivatives and its metabolites
  • sulfur-containing amino acids, its derivatives and its metabolites
  • sulfur compounds

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Related Special Issue

Published Papers (3 papers)

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Research

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15 pages, 1213 KiB  
Article
Upregulation of Taurine Biosynthesis and Bile Acid Conjugation with Taurine through FXR in a Mouse Model with Human-like Bile Acid Composition
by Teruo Miyazaki, Hajime Ueda, Tadashi Ikegami and Akira Honda
Metabolites 2023, 13(7), 824; https://doi.org/10.3390/metabo13070824 - 5 Jul 2023
Cited by 5 | Viewed by 2557
Abstract
Taurine, the end product in the sulfur-containing amino acid pathway, is conjugated with bile acids (BAs) in the liver. The rate-limiting enzymes in both taurine synthesis and BA conjugation may be regulated by a nucleus receptor, FXR, that promotes BA homeostasis. However, it [...] Read more.
Taurine, the end product in the sulfur-containing amino acid pathway, is conjugated with bile acids (BAs) in the liver. The rate-limiting enzymes in both taurine synthesis and BA conjugation may be regulated by a nucleus receptor, FXR, that promotes BA homeostasis. However, it is controversial because BAs act as natural FXR agonists or antagonists in humans and mice, respectively, due to the species differences in BA synthesis. The present study evaluated the influences of different BA compositions on both pathways in the liver by comparing Cyp2a12−/−/Cyp2c70−/− mice with a human-like BA composition (DKO) and wild-type (WT) mice. The DKO liver contains abundant natural FXR agonistic BAs, and the taurine-conjugated BA proportion and the taurine concentration were significantly increased, while the total BA concentration was significantly decreased compared to those in the WT liver with natural FXR antagonistic BAs. The mRNA expression levels of the enzymes Bacs and Baat in BA aminations and Cdo and Fmo1 in the taurine synthesis, as well as Fxr and its target gene, Shp, were significantly higher in the DKO liver than in the WT liver. The present study, using a model with a human-like BA composition in the liver, confirmed, for the first time in mice, that both the taurine synthesis and BA amidation pathways are upregulated by FXR activation. Full article
(This article belongs to the Special Issue Regulation and Effect of Sulfur-Containing Amino Acids and Sulfur Compounds on Metabolism 2nd Edition)
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14 pages, 2617 KiB  
Article
Muscle Pathology in Dystrophic Rats and Zebrafish Is Unresponsive to Taurine Treatment, Compared to the mdx Mouse Model for Duchenne Muscular Dystrophy
by Jessica R. Terrill, Corinne Huchet, Caroline Le Guiner, Aude Lafoux, Dorian Caudal, Ankita Tulangekar, Robert J. Bryson-Richardson, Tamar E. Sztal, Miranda D. Grounds and Peter G. Arthur
Metabolites 2023, 13(2), 232; https://doi.org/10.3390/metabo13020232 - 4 Feb 2023
Cited by 2 | Viewed by 2295
Abstract
Inflammation and oxidative stress are strongly implicated in the pathology of Duchenne muscular dystrophy (DMD), and the sulphur-containing amino acid taurine ameliorates both and decreases dystropathology in the mdx mouse model for DMD. We therefore further tested taurine as a therapy using dystrophic [...] Read more.
Inflammation and oxidative stress are strongly implicated in the pathology of Duchenne muscular dystrophy (DMD), and the sulphur-containing amino acid taurine ameliorates both and decreases dystropathology in the mdx mouse model for DMD. We therefore further tested taurine as a therapy using dystrophic DMDmdx rats and dmd zebrafish models for DMD that have a more severe dystropathology. However, taurine treatment had little effect on the indices of dystropathology in both these models. While we and others have previously observed a deficiency in taurine in mdx mice, in the current study we show that the rat and zebrafish models had increased taurine content compared with wild-type, and taurine treatment did not increase muscle taurine levels. We therefore hypothesised that endogenous levels of taurine are a key determinate in potential taurine treatment efficacy. Because of this, we felt it important to measure taurine levels in DMD patient plasma samples and showed that in non-ambulant patients (but not in younger patients) there was a deficiency of taurine. These data suggest that taurine homeostasis varies greatly between species and may be influenced by age and disease progression. The potential for taurine to be an effective therapy may depend on such variables. Full article
(This article belongs to the Special Issue Regulation and Effect of Sulfur-Containing Amino Acids and Sulfur Compounds on Metabolism 2nd Edition)
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Review

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19 pages, 1502 KiB  
Review
Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease
by Chih-Jen Chen, Ming-Chou Cheng, Chien-Ning Hsu and You-Lin Tain
Metabolites 2023, 13(6), 688; https://doi.org/10.3390/metabo13060688 - 25 May 2023
Cited by 6 | Viewed by 3221
Abstract
Hydrogen sulfide (H2S) plays a decisive role in kidney health and disease. H2S can ben synthesized via enzymatic and non-enzymatic pathways, as well as gut microbial origins. Kidney disease can originate in early life induced by various maternal insults [...] Read more.
Hydrogen sulfide (H2S) plays a decisive role in kidney health and disease. H2S can ben synthesized via enzymatic and non-enzymatic pathways, as well as gut microbial origins. Kidney disease can originate in early life induced by various maternal insults throughout the process, namely renal programming. Sulfur-containing amino acids and sulfate are essential in normal pregnancy and fetal development. Dysregulated H2S signaling behind renal programming is linked to deficient nitric oxide, oxidative stress, the aberrant renin–angiotensin–aldosterone system, and gut microbiota dysbiosis. In animal models of renal programming, treatment with sulfur-containing amino acids, N-acetylcysteine, H2S donors, and organosulfur compounds during gestation and lactation could improve offspring’s renal outcomes. In this review, we summarize current knowledge regarding sulfide/sulfate implicated in pregnancy and kidney development, current evidence supporting the interactions between H2S signaling and underlying mechanisms of renal programming, and recent advances in the beneficial actions of sulfide-related interventions on the prevention of kidney disease. Modifying H2S signaling is the novel therapeutic and preventive approach to reduce the global burden of kidney disease; however, more work is required to translate this into clinical practice. Full article
(This article belongs to the Special Issue Regulation and Effect of Sulfur-Containing Amino Acids and Sulfur Compounds on Metabolism 2nd Edition)
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