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Metabolites
Special Issues
Interplay between Metabolism and Vascular Ageing in Chronic Kidney Disease
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Interplay between Metabolism and Vascular Ageing in Chronic Kidney Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (1 July 2023) | Viewed by 7417

Special Issue Editors

Dr. Živka Dika

E-Mail Website
Guest Editor
Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Univertisty Hospital Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Interests: arterial hypertension; cardiometabolic disorders in kidney disease; chronic kidney disease; toxic nepropathies; kidney biomarkers; urolithiasis
Dr. Bojan Jelaković

E-Mail Website
Guest Editor
Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Univertisty Hospital Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Interests: arterial hypertension; chronic kidney disease; Balkan endemic nephropathy; epidemiology; public health; preventive cardiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is a common non-communicable disease (NCD) of heterogeneous causes, with diabetes and arterial hypertension being the leading causes of kidney failure. The global burden of CKD and mortality from CKD have increased over the last three decades. In addition to the physiological aging of the kidneys, the kidneys and their vasculature age faster in CKD patients. Most patients with CKD die from cardiovascular disease. Premature vascular aging in these patients is the result of metabolic, hematological, and hemodynamic changes that occur at different CKD stages. This Special Issue highlights the interplay between metabolism and vascular ageing in CKD patients throughout all CKD stages; the role of gut dysbiosis and anemia on vascular and renal aging; and diagnostic and novel treatment strategies and future perspectives. Early detection and the prevention of risk factors for CKD, as well as risk factors for the progression of CKD, are key in reducing premature morbidity and mortality and preventing additional treatment costs.

Dr. Živka Dika
Dr. Bojan Jelaković
Guest Editors

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Keywords

  • Chronic Kidney Disease (CKD)
  • Early Vascular Aging (EVA)
  • renal aging
  • metabolism
  • cardiovascular disease
  • cardiovascular risk
  • vascular health management
  • cardiovascular prevention

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Published Papers (3 papers)

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Research

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11 pages, 2152 KiB  
Article
Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study
by Li Yin, Zhengzhipeng Zhang, Changming Xie, Dongling Luo, Wanbing He, Suli Huang and Hui Huang
Metabolites 2022, 12(12), 1258; https://doi.org/10.3390/metabo12121258 - 14 Dec 2022
Viewed by 1493
Abstract
Many studies have documented that dental diseases were associated with an increased risk of cardiovascular diseases. Aortic arch calcification (AoAC) is a powerful predictor of cardiovascular diseases. However, whether the status of dental health is associated with AoAC is still unknown. 9463 participants [...] Read more.
Many studies have documented that dental diseases were associated with an increased risk of cardiovascular diseases. Aortic arch calcification (AoAC) is a powerful predictor of cardiovascular diseases. However, whether the status of dental health is associated with AoAC is still unknown. 9463 participants over the age of 60 from Shenzhen community centers were included in the cross-sectional analysis. Physical examination data, blood biochemical tests, and AoAC scores calculated by chest radiography were collected and analyzed. Among them, 2630 participants were followed up for AoAC progression up to 36 months. Participants with AoAC suffered more tooth loss than those without AoAC (77.62% vs. 72.91%; p < 0.001). Association rule analysis suggested a strong association between dental diseases and AoAC. Tooth loss or decay increased the risk of AoAC progression (HR 1.459; 95%CI 1.284–1.658) after adjusting other risk factors including renal dysfunction. Dental diseases are potential predictors for AoAC in elderly people, which are independent of renal dysfunction. Full article
(This article belongs to the Special Issue Interplay between Metabolism and Vascular Ageing in Chronic Kidney Disease)
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12 pages, 801 KiB  
Article
Isolated Effects of Plasma Freezing versus Thawing on Metabolite Stability
by Jane L. Buchanan, Jovan Tormes Vaquerano and Eric B. Taylor
Metabolites 2022, 12(11), 1098; https://doi.org/10.3390/metabo12111098 - 11 Nov 2022
Cited by 3 | Viewed by 2062
Abstract
Freezing and thawing plasma samples is known to perturb metabolite stability. However, no study has systematically tested how different freezing and thawing methods affect plasma metabolite levels. The objective of this study was to isolate the effects of freezing from thawing on mouse [...] Read more.
Freezing and thawing plasma samples is known to perturb metabolite stability. However, no study has systematically tested how different freezing and thawing methods affect plasma metabolite levels. The objective of this study was to isolate the effects of freezing from thawing on mouse plasma metabolite levels, by comparing a matrix of freezing and thawing conditions through 10 freeze–thaw cycles. We tested freezing with liquid nitrogen (LN2), at −80 °C, or at −20 °C, and thawing quickly in room temperature water or slowly on ice. Plasma samples were extracted and the relative abundance of 87 metabolites was obtained via liquid chromatography–mass spectrometry (LC–MS). Observed changes in metabolite abundance by treatment group correlated with the amount of time it took for samples to freeze or thaw. Thus, snap-freezing with LN2 and quick-thawing with water led to minimal changes in metabolite levels. Conversely, samples frozen at −20 °C exhibited the most changes in metabolite levels, likely because freezing required about 4 h, versus freezing instantaneously in LN2. Overall, our results show that plasma samples subjected to up to 10 cycles of LN2 snap-freezing with room temperature water quick-thawing exhibit remarkable metabolomic stability. Full article
(This article belongs to the Special Issue Interplay between Metabolism and Vascular Ageing in Chronic Kidney Disease)
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Review

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16 pages, 1271 KiB  
Review
Hypomagnesemia as a Risk Factor and Accelerator for Vascular Aging in Diabetes Mellitus and Chronic Kidney Disease
by Ákos Géza Pethő, Mihály Tapolyai, Maria Browne and Tibor Fülöp
Metabolites 2023, 13(2), 306; https://doi.org/10.3390/metabo13020306 - 19 Feb 2023
Cited by 11 | Viewed by 3153
Abstract
The age-old axiom that one is as old as his or her vessels are, calls for ongoing critical re-examination of modifiable risk factors of accelerated vascular ageing in chronic kidney diseases. Attempts to modulate vascular risk with cholesterol-lowering agents have largely failed in [...] Read more.
The age-old axiom that one is as old as his or her vessels are, calls for ongoing critical re-examination of modifiable risk factors of accelerated vascular ageing in chronic kidney diseases. Attempts to modulate vascular risk with cholesterol-lowering agents have largely failed in advanced chronic kidney disease (CKD). In addition to nitrogen waste products, many pathological biochemical processes also play a role in vascular calcification in chronic kidney damage. Magnesium, a cation vital for the body, may substantially reduce cardiovascular diseases’ risk and progression. This narrative review aimed to address the relationship between hypomagnesemia and vascular calcification, which promotes further cardiovascular complications in diabetes, aging, and CKD. Articles with predefined keywords were searched for in the PubMed and Google Scholar databases with specific inclusion and exclusion criteria. We hypothesized that a decrease in serum magnesium levels contributes to increased vascular calcification and thereby increases cardiovascular mortality. In summary, based on existing evidence in the literature, it appears that simple and inexpensive oral magnesium supplementation may reduce the cardiovascular mortality of patients who are already severely affected by such diseases; in this context, the concept of ‘normal’ vs. ‘ideal’ serum magnesium levels should be carefully re-examined. Full article
(This article belongs to the Special Issue Interplay between Metabolism and Vascular Ageing in Chronic Kidney Disease)
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