Reactive Oxygen Species and Energy Metabolic Alterations in Health and Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2030

Special Issue Editors


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Guest Editor
Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico
Interests: cancer; metabolism; autophagy; reactive oxygen species; phytochemicals
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Guest Editor
Departamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico
Interests: mitochondria; intermediary metabolism; glycolysis; cancer; enzyme
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Cellular alterations in energy metabolism and metabolic reprogramming are considered hallmarks of diverse diseases including cancer, neurodegenerative diseases and certainly, metabolic disorders like metabolic syndrome and diabetes. For example, an altered cellular metabolism has been recognized as one of the hallmarks of cancer since malignant cells are known to divert flux through their metabolic pathways (glycolysis, pentose phosphate pathway, Krebs cycle, etc.) to increase macromolecule and organelle biosynthesis to maintain active cellular proliferation. Recent research has associated some of these metabolic changes, particularly in mitochondria, to the production of reactive oxygen species (ROS), reactive oxygen by-products with a strong oxidation and signaling functions.

This Special Issue welcomes submissions of original research and reviews from diverse areas of cellular biology and biomedical research fields concerned with metabolic and ROS functions and alterations in human diseases, with the purpose of stimulating intriguing perspectives in the discipline.

Dr. Paola Maycotte
Dr. Álvaro Marín-Hernández
Guest Editors

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Keywords

  • cancer
  • ROS
  • glycolysis
  • mitochondria
  • autophagy
  • antioxidant system
  • glutathione
  • oxidative phosphorylation

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Published Papers (1 paper)

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Research

17 pages, 3381 KiB  
Article
Metabolic and Oxidative Stress Management Heterogeneity in a Panel of Breast Cancer Cell Lines
by Paola Maycotte, Fabiola Lilí Sarmiento-Salinas, Alin García-Miranda, Cesar Ivan Ovando-Ovando, Diana Xochiquetzal Robledo-Cadena, Luz Hernández-Esquivel, Ricardo Jasso-Chávez and Alvaro Marín-Hernández
Metabolites 2024, 14(8), 435; https://doi.org/10.3390/metabo14080435 - 6 Aug 2024
Viewed by 1677
Abstract
Metabolic alterations are recognized as one of the hallmarks of cancer. Among these, alterations in mitochondrial function have been associated with an enhanced production of Reactive Oxygen Species (ROS), which activate ROS-regulated cancer cell signaling pathways. Breast cancer is the main cancer-related cause [...] Read more.
Metabolic alterations are recognized as one of the hallmarks of cancer. Among these, alterations in mitochondrial function have been associated with an enhanced production of Reactive Oxygen Species (ROS), which activate ROS-regulated cancer cell signaling pathways. Breast cancer is the main cancer-related cause of death for women globally. It is a heterogeneous disease with subtypes characterized by specific molecular features and patient outcomes. With the purpose of identifying differences in energy metabolism and the oxidative stress management system in non-tumorigenic, estrogen receptor positive (ER+) and triple negative (TN) breast cancer cells, we evaluated ROS production, protein enzyme levels and activities and profiled energy metabolism. We found differences in energetic metabolism and ROS management systems between non-tumorigenic and cancer cells and between ER+ and TN breast cancer cells. Our results indicate a dependence on glycolysis despite different glycolytic ATP levels in all cancer cell lines tested. In addition, our data show that high levels of ROS in TN cells are a result of limited antioxidant capacity in the NADPH producing and GSH systems, mitochondrial dysfunction and non-mitochondrial ROS production, making them more sensitive to GSH synthesis inhibitors. Our data suggest that metabolic and antioxidant profiling of breast cancer will provide important targets for metabolic inhibitors or antioxidant treatments for breast cancer therapy. Full article
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