Bacterial Secondary Metabolite Biosynthesis and Application for Biopharmaceutical and Bioengineering
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".
Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 6020
Special Issue Editor
Interests: marine drug leads; efficient discovery; biosynthesis; fermentation preparation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bacterial natural products (NPs) are some of the most important sources of therapeutic agents. These NP-based drugs have made a tremendous contribution to human health throughout the world since they constitute half of the pharmaceuticals on the market today. However, the emerging and re-emerging infectious diseases (e.g., drug-resistant pathogens, coronavirus variants) pose complex and serious challenges to the global public health and the need for new antibiotics is highly urgent. In the past two decades, bacterial NPs have greatly decreased. Fortunately, the application of new interdisciplinary approaches (e.g., genome mining and shuffling, metabolomics, ribosome engineering, heterologous expression) has substantially improved our ability to discover and develop novel functional biomolecules from these microbes and reinvigorated interest in natural product research in recent years.
This Special Issue welcomes both fundamental research papers and critical review works in the most recent and innovative developments of bacterial NP biosynthesis and application for biopharmaceutical and bioengineering. We sincerely wish that this issue can collect groundbreaking contributions in this field.
Prof. Dr. Huawei Zhang
Guest Editor
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Keywords
- new bacterial NP discovery and biosynthetic analysis
- antibiotic biosynthesis
- extending metabolite diversity
- genome mining and metabolomics
- gene characterization and heteroexpression
- activation of cryptic gene cluster of secondary metabolite
- enhancement of valuable metabolite production
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