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Microbiology Research
Special Issues
Antifungal Activities of Plant Extracts
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Antifungal Activities of Plant Extracts

A special issue of Microbiology Research (ISSN 2036-7481).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1571

Special Issue Editor

Prof. Dr. Julliana Ribeiro Alves Santos

E-Mail Website
Guest Editor
Instituto de Ciências Biológicas (ICB), Universidade de Pernambuco (UPE), Recife, Pernambuco, Brazil
Interests: medical mycology; antifungal resistance; antifungal treatment; coinfection; yeast; filamentous fungi; molecular characterization of fungi; phenotypic characterization of fungi; fungal pathogenicity

Special Issue Information

Dear Colleagues,

Mycoses are responsible for high rates of morbidity and mortality. One of the major problems related to these diseases is antifungal treatment, due to the limited number of antifungal drugs and increasing cases of antifungal resistance. In this context, natural plant products stand out as an important alternative for the treatment of mycoses.

This Special Issue will address the antifungal activity of plant extracts for insights into the potential of natural products for the treatment of mycoses.

This Special Issue of the Microbiology Research will present state-of-the-art reviews and research articles on the topic of “Antifungal Activities of Plant Extracts” in order to support antifungal treatment.

Prof. Dr. Julliana Ribeiro Alves Santos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microbiology Research is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antifungal activity
  • plant extracts
  • mycoses treatment
  • natural products
  • yeast
  • filamentous fungi

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Published Papers (1 paper)

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Research

18 pages, 2923 KiB  
Article
In Vitro and In Vivo Wide-Spectrum Dual Antimycetomal Activity of Eight Essential Oils Coupled with Chemical Composition and Metabolomic Profiling
by Shereen O. Abd Algaffar, Prabodh Satyal, Naglaa S. Ashmawy, Annelies Verbon, Wendy W. J. van de Sande and Sami A. Khalid
Microbiol. Res. 2024, 15(3), 1280-1297; https://doi.org/10.3390/microbiolres15030086 - 22 Jul 2024
Viewed by 864
Abstract
Mycetoma, a neglected infection of subcutaneous tissues, poses a significant health burden, especially in tropical regions. It is caused by fungal (eumycetoma) and bacterial (actinomycetoma) pathogens, with current treatments often providing unsatisfactory outcomes. This study aims to discover novel broad-spectrum antimicrobial agents to [...] Read more.
Mycetoma, a neglected infection of subcutaneous tissues, poses a significant health burden, especially in tropical regions. It is caused by fungal (eumycetoma) and bacterial (actinomycetoma) pathogens, with current treatments often providing unsatisfactory outcomes. This study aims to discover novel broad-spectrum antimicrobial agents to circumvent the lengthy and costly diagnostic procedures. Eight essential oils (EOs) from the roots and aerial parts of Geigeria alata, Lavandula angustifolia, Melaleuca alternifolia, Myristica fragrans, Pimpinella anisum, Syzigum aromaticum, and Thymus vulgaris were prepared using steam distillation. The in vitro antimycetomal activity against Madurella mycetomatis and Actinomadura madurae strains was assessed using resazurin assays. The chemical compositions of the EOs were analyzed using gas chromatography and mass spectrometry (GC–MS). Promising EOs underwent further in vivo toxicity and efficacy testing in Galleria mellonella larvae models. EOs of G. alata roots, M. fragrans, P. anisum, S. aromaticum, and T. vulgaris showed wide-spectrum dual in vitro antimycetomal activity against all tested strains, with minimum inhibitory concentrations (MICs) ranging from 0.004 to 0.125% v/v. G. alata aerial parts and L. angustifolia EOs demonstrated activity predominantly against A. madurae, while M. alternifolia EO did not inhibit any tested strains. M. fragrans and P. anisum EOs significantly enhanced the survival of M. mycetomatis-infected larvae without inducing toxicity in uninfected larvae. Notably, P. anisum EO tended to enhance the survival of A. madurae-infected larvae, ranking it as the most promising EO among those tested. The investigated EOs, particularly P. anisum, exhibited promising broad-spectrum antimycetomal activity against fungal and bacterial pathogens responsible for mycetoma. These findings highlight the potential of essential oils as a basis for developing novel antimycetomal agents, offering hope for improved treatment strategies for this neglected disease. Full article
(This article belongs to the Special Issue Antifungal Activities of Plant Extracts)
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