Oral Microorganisms and Systemic Diseases

A special issue of Microbiology Research (ISSN 2036-7481).

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 5449

Special Issue Editors


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Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, 84081 Salerno, Italy
Interests: dentistry; microbiology; paediatric dentistry; periodontology; implantology

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Guest Editor
Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84100 Salerno, Italy
Interests: restorative dentistry; pediatric dentistry; endodontics; esthetic dentistry; dental materials; dental public health
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Special Issue Information

Dear Colleagues,

The human being is a superorganism made up of both its own cells and microorganisms that live on or in the human body. Most of these microorganisms are commensals and perform very important functions for humans. However, in the event of systemic problems or immunosuppression on the part of the subject, these microorganisms can become pathogenic and cause systemic problems or contribute to the aggravation of systemic disease pictures. In fact, under particular conditions, the virulence factors of oral microorganisms can reach distant organs or affect host immune responses.

Dr. Giuseppe Sangiovanni
Dr. Alfredo Iandolo
Dr. Francesco D’Ambrosio
Dr. Massimo Pisano
Guest Editors

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Keywords

  • dentistry
  • microorganism
  • oral pathogens
  • periodontology
  • endodontics

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Published Papers (1 paper)

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Review

17 pages, 624 KiB  
Review
The Interaction between the Oral Microbiome and Systemic Diseases: A Narrative Review
by Massimo Pisano, Francesco Giordano, Giuseppe Sangiovanni, Nicoletta Capuano, Alfonso Acerra and Francesco D’Ambrosio
Microbiol. Res. 2023, 14(4), 1862-1878; https://doi.org/10.3390/microbiolres14040127 - 9 Nov 2023
Cited by 12 | Viewed by 4960
Abstract
Background: The human being is defined as a ‘superorganism’ since it is made up of its own cells and microorganisms that reside inside and outside the human body. Commensal microorganisms, which are even ten times more numerous than the cells present in [...] Read more.
Background: The human being is defined as a ‘superorganism’ since it is made up of its own cells and microorganisms that reside inside and outside the human body. Commensal microorganisms, which are even ten times more numerous than the cells present in the body, perform very important functions for the host, as they contribute to the health of the host, resist pathogens, maintain homeostasis, and modulate the immune system. In the mouth, there are different types of microorganisms, such as viruses, mycoplasmas, bacteria, archaea, fungi, and protozoa, often organized in communities. The aim of this umbrella review is to evaluate if there is a connection between the oral microbiome and systematic diseases. Methodology: A literature search was conducted through PubMed/MEDLINE, the COCHRANE library, Scopus, and Web of Science databases without any restrictions. Because of the large number of articles included and the wide range of methods and results among the studies found, it was not possible to report the results in the form of a systematic review or meta-analysis. Therefore, a narrative review was conducted. We obtained 73.931 results, of which 3593 passed the English language filter. After the screening of the titles and abstracts, non-topic entries were excluded, but most articles obtained concerned interactions between the oral microbiome and systemic diseases. Discussion: A description of the normal microbial flora was present in the oral cavity both in physiological conditions and in local pathological conditions and in the most widespread systemic pathologies. Furthermore, the therapeutic precautions that the clinician can follow in order to intervene on the change in the microbiome have been described. Conclusions: This review highlights what are the intercorrelations of the oral microbiota in healthy subjects and in subjects in pathological conditions. According to several recent studies, there is a clear correlation between dysbiosis of the oral microbiota and diseases such as diabetes, cardiovascular diseases, chronic inflammatory diseases, and neurodegenerative diseases. Full article
(This article belongs to the Special Issue Oral Microorganisms and Systemic Diseases)
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