Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.0
Journals
Micromachines
Special Issues
Optical Coherence Tomography (OCT) Technique and Its Applications
share announcement

Optical Coherence Tomography (OCT) Technique and Its Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 5005

Special Issue Editor

Dr. Shaohua Pi

E-Mail Website
Guest Editor
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Interests: optical coherence tomography; ophthalmic imaging

Special Issue Information

Dear Colleagues,

Optical coherence tomography (OCT) has become an indispensable tool with the capability of offering in vivo, non-invasive, micron-resolution, dye-free, and 3D imaging. It has now been widely used in clinics and research to image living animals and humans. OCT works as a Michelson Interferometer where the light backscattered from biological tissue interferes with the light traveling in the reference arm. For time-domain OCT (TD-OCT), the reference mirror moves periodically to scan along the axial direction. For Fourier-domain OCT (FD-OCT), the interference is captured either by a spectrometer in spectral-domain OCT (SD-OCT) or by a photodetector in a swept-source OCT (SS-OCT). The emerging extensions of OCT include OCT angiography (OCTA), polarization-sensitive OCT (PS-OCT), Doppler OCT, full-field OCT (FF-OCT), and OCT oximetry. These technologies hold great potential in ophthalmology, dermatology, neuroscience, and other fields. Accordingly, this Special Issue seeks to showcase research papers, communications, and review articles that focus on novel methodological developments and bioengineering applications of OCT.

We look forward to receiving your submissions.

Dr. Shaohua Pi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopsy
  • biomedical applications
  • optical coherence tomography
  • optical imaging
  • eye
  • brain
  • skin

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

9 pages, 7405 KiB  
Article
Quantitative Optimization of Handheld Probe External Pressure on Dermatological Microvasculature Using Optical Coherence Tomography-Based Angiography
by Jiacheng Gu, Jinpeng Liao, Tianyu Zhang, Yilong Zhang, Zhihong Huang and Chunhui Li
Micromachines 2024, 15(9), 1128; https://doi.org/10.3390/mi15091128 - 4 Sep 2024
Viewed by 782
Abstract
Optical Coherence Tomography (OCT)-based angiography (OCTA) is a high-resolution, high-speed, and non-invasive imaging method that can provide vascular mapping of subcutaneous tissue up to approximately 2 mm. In dermatology applications of OCTA, handheld probes are always designed with a piece of transparent but [...] Read more.
Optical Coherence Tomography (OCT)-based angiography (OCTA) is a high-resolution, high-speed, and non-invasive imaging method that can provide vascular mapping of subcutaneous tissue up to approximately 2 mm. In dermatology applications of OCTA, handheld probes are always designed with a piece of transparent but solid contact window placed at the end of the probe to directly contact the skin for achieving better focusing between the light source and the tissue, reducing noise caused by minor movements. The pressure between the contact window and the skin is usually uncontrollable, and high external pressure affects the quality of microvascular imaging by compressing the vessels and obstructing the underlying blood flow. Therefore, it is necessary to determine a pressure range to ensure that the vessels can be fully imaged in high-quality images. In this paper, two pressure sensors were added to the existing handheld OCT probe, and the imaging probe was fixed to a metal stand and adjusted vertically to change the pressure between the probe and the tested skin site, a gradient of roughly 4 kPa (with 1–2 kPa error) increase was applied in each experiment, and the impact of pressure to the vessel was calculated. The experiment involved a total of five subjects, three areas of which were scanned (palm, back of the hand, and forearm). The vessel density was calculated to evaluate the impact of external pressure on angiography. In addition, PSNR was calculated to ensure that the quality of different tests was at a similar level. The angiography showed the highest density (about 10%) when the pressure between the contact window on the probe and the test area was between 3 and 5 kPa. As the pressure increased, the vascular density decreased, and the rate of decrease varied in different test areas. After fitting all the data points according to the different sites, the slope of the fitted line, i.e., the rate of decrease in density per unit value of pressure, was found to be 4.05% at the palm site, 6.93% at the back of the hand, and 4.55% at the forearm site. This experiment demonstrates that the pressure between the skin and contact window is a significant parameter that cannot be ignored. It is recommended that in future OCTA data collection processes and probe designs, the impact of pressure on the experiment be considered. Full article
(This article belongs to the Special Issue Optical Coherence Tomography (OCT) Technique and Its Applications)
►▼ Show Figures

Figure 1

13 pages, 21488 KiB  
Article
Assessment of Early Glaucomatous Optic Neuropathy in the Dog by Spectral Domain Optical Coherence Tomography (SD-OCT)
by Annie Oh, Christine D. Harman, Kristin L. Koehl, Jiayan Huang, Leandro B. C. Teixeira, Laurence M. Occelli, Eric S. Storey, Gui-Shuang Ying and András M. Komáromy
Micromachines 2024, 15(6), 780; https://doi.org/10.3390/mi15060780 - 13 Jun 2024
Viewed by 1021
Abstract
Background: Inherited primary open-angle glaucoma (POAG) in Beagle dogs is a well-established large animal model of glaucoma and is caused by a G661R missense mutation in the ADAMTS10 gene. Using this model, the study describes early clinical disease markers for canine glaucoma. Methods: [...] Read more.
Background: Inherited primary open-angle glaucoma (POAG) in Beagle dogs is a well-established large animal model of glaucoma and is caused by a G661R missense mutation in the ADAMTS10 gene. Using this model, the study describes early clinical disease markers for canine glaucoma. Methods: Spectral-domain optical coherence tomography (SD-OCT) was used to assess nine adult, ADAMTS10-mutant (median age 45.6 months, range 28.8–52.8 months; mean diurnal intraocular pressure (IOP): 29.9 +/− SEM 0.44 mmHg) and three related age-matched control Beagles (mean diurnal IOP: 18.0 +/− SEM 0.53 mmHg). Results: Of all the optic nerve head (ONH) parameters evaluated, the loss of myelin peak height in the horizontal plane was most significant (from 154 +/− SEM 38.4 μm to 9.3 +/− SEM 22.1 μm; p < 0.01). There was a strong significant negative correlation between myelin peak height and IOP (Spearman correlation: −0.78; p < 0.003). There were no significant differences in the thickness of any retinal layers evaluated. Conclusions: SD-OCT is a useful tool to detect early glaucomatous damage to the ONH in dogs before vision loss. Loss in myelin peak height without inner retinal thinning was identified as an early clinical disease marker. This suggests that initial degenerative changes are mostly due to the loss of myelin. Full article
(This article belongs to the Special Issue Optical Coherence Tomography (OCT) Technique and Its Applications)
►▼ Show Figures

Figure 1

9 pages, 2326 KiB  
Article
A Novel Small Form-Factor Handheld Optical Coherence Tomography Probe for Oral Soft Tissue Imaging
by Alok K. Kushwaha, Minqi Ji, Sneha Sethi, Lisa Jamieson, Robert A. McLaughlin and Jiawen Li
Micromachines 2024, 15(6), 742; https://doi.org/10.3390/mi15060742 - 31 May 2024
Viewed by 925
Abstract
Tissue imaging is crucial in oral cancer diagnostics. Imaging techniques such as X-ray imaging, magnetic resonance imaging, optical coherence tomography (OCT) and computed tomography (CT) enable the visualization and analysis of tissues, aiding in the detection and diagnosis of cancers. A significant amount [...] Read more.
Tissue imaging is crucial in oral cancer diagnostics. Imaging techniques such as X-ray imaging, magnetic resonance imaging, optical coherence tomography (OCT) and computed tomography (CT) enable the visualization and analysis of tissues, aiding in the detection and diagnosis of cancers. A significant amount of research has been conducted on designing OCT probes for tissue imaging, but most probes are either heavy, bulky and require external mounting or are lightweight but straight. This study addresses these challenges, resulting in a curved lightweight, low-voltage and compact handheld imaging probe for oral soft tissue examination. To the best of our knowledge, this is the first curved handheld OCT probe with its shape optimized for oral applications. This probe features highly compact all-fiber optics with a diameter of 125 μm and utilizes innovative central deflection magnetic actuation for controlled beam scanning. To ensure vertical stability while scanning oral soft tissues, the fiber was secured through multiple narrow slits at the probe’s distal end. This apparatus was encased in a 3D-printed angular cylinder tube (15 mm outer diameter, 12 mm inner diameter and 160 mm in length, weighing < 20 g). An angle of 115° makes the probe easy to hold and suitable for scanning in space-limited locations. To validate the feasibility of this probe, we conducted assessments on a multi-layered imaging phantom and human tissues, visualizing microstructural features with high contrast. Full article
(This article belongs to the Special Issue Optical Coherence Tomography (OCT) Technique and Its Applications)
►▼ Show Figures

Figure 1

Review

Jump to: Research

24 pages, 17770 KiB  
Review
Growing Trend to Adopt Speckle Variance Optical Coherence Tomography for Biological Tissue Assessments in Pre-Clinical Applications
by Ruchire Eranga Wijesinghe, Nipun Shantha Kahatapitiya, Changho Lee, Sangyeob Han, Shinheon Kim, Sm Abu Saleah, Daewoon Seong, Bhagya Nathali Silva, Udaya Wijenayake, Naresh Kumar Ravichandran, Mansik Jeon and Jeehyun Kim
Micromachines 2024, 15(5), 564; https://doi.org/10.3390/mi15050564 - 25 Apr 2024
Cited by 1 | Viewed by 1384
Abstract
Speckle patterns are a generic feature in coherent imaging techniques like optical coherence tomography (OCT). Although speckles are granular like noise texture, which degrades the image, they carry information that can be benefited by processing and thereby furnishing crucial information of sample structures, [...] Read more.
Speckle patterns are a generic feature in coherent imaging techniques like optical coherence tomography (OCT). Although speckles are granular like noise texture, which degrades the image, they carry information that can be benefited by processing and thereby furnishing crucial information of sample structures, which can serve to provide significant important structural details of samples in in vivo longitudinal pre-clinical monitoring and assessments. Since the motions of tissue molecules are indicated through speckle patterns, speckle variance OCT (SV-OCT) can be well-utilized for quantitative assessments of speckle variance (SV) in biological tissues. SV-OCT has been acknowledged as a promising method for mapping microvasculature in transverse-directional blood vessels with high resolution in micrometers in both the transverse and depth directions. The fundamental scope of this article reviews the state-of-the-art and clinical benefits of SV-OCT to assess biological tissues for pre-clinical applications. In particular, focus on precise quantifications of in vivo vascular response, therapy assessments, and real-time temporal vascular effects of SV-OCT are primarily emphasized. Finally, SV-OCT-incorporating pre-clinical techniques with high potential are presented for future biomedical applications. Full article
(This article belongs to the Special Issue Optical Coherence Tomography (OCT) Technique and Its Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop