Bio-MEMS for Cell and Tissue Engineering

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 6575

Special Issue Editor


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Guest Editor
Department of Biomedical Engineering, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
Interests: cardiomyocyte; metabolic switching; functional maturation
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Special Issue Information

Dear Colleagues,

The application of MEMS technology to biology has contributed to a wide range of application from basic biology to clinical applications. In particular, engineering cells and tissues by the development of bio-MEMS technologies have elucidated the fundamentals of cellular behaviour, the mechanisms of cell and tissue assembly, and the conditions of clinical applications in tissue regeneration. Recent development of microfabrication technologies such as complex microfluidic chips, 3D micro- patterning, and 3D lithography leads us to new research areas that have not been challenged before in cell tissue engineering. Research areas such as organoid formation, body on a chip, and microphysiological sysems will be novel challenging fields using these novel MEMS technologies. 

This Special Issue will collect research papers, short communications, and review articles that focus on novel bio-MEMS technologies for engineering cells and/or tissue.

Prof. Yongdoo Park
Guest Editor

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Keywords

  • microfluidics
  • micropatterning
  • cell and tissue assembly
  • body on a chip
  • tissue regeneration

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Published Papers (1 paper)

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Review

38 pages, 9793 KiB  
Review
Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering
by Ana Rita M. P. Santos, Yongjun Jang, Inwoo Son, Jongseong Kim and Yongdoo Park
Micromachines 2021, 12(4), 386; https://doi.org/10.3390/mi12040386 - 1 Apr 2021
Cited by 9 | Viewed by 6177
Abstract
Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro [...] Read more.
Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering techniques from simple to complex for fabricating matured cardiac tissue in vitro. Advancements in cardiomyocytes, extracellular matrix, geometry, and computational modeling will be discussed based on a technology perspective and their use for preparation of functional cardiac tissue. Since the heart is a very complex system at multiscale levels, an understanding of each technique and their interactions would be highly beneficial to the development of a fully functional heart in cardiac tissue engineering. Full article
(This article belongs to the Special Issue Bio-MEMS for Cell and Tissue Engineering)
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