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Micromachines
Special Issues
Ultrafast Photonics for Biomedical, Biological and Life Science Applications
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Ultrafast Photonics for Biomedical, Biological and Life Science Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "D：Materials and Processing".

Deadline for manuscript submissions: closed (10 April 2024) | Viewed by 4962

Special Issue Editors

Dr. Cyril Mauclair

E-Mail Website
Guest Editor
Hubert Curien Laboratory, Jean Monnet University, 18 Rue Professeur Benoît Lauras, 42100 Saint-Etienne, France
Interests: ultrafast laser surface machining; spatial beam shaping; ultrafast laser bulk machining; temporal pulse shaping
Special Issues, Collections and Topics in MDPI journals
Dr. Xxx Sedao

E-Mail Website
Guest Editor
Hubert Curien Laboratory, Jean Monnet University, 18 Rue Professeur Benoît Lauras, 42100 Saint-Etienne, France
Interests: surface functionalization; laser induced periodic surface structures (LIPSS); lasers for biomimetics; surface characterization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Courtesy of its ultimate precision, ultrafast laser patterning has become a widespread technique for the micro- and nanostructuring of bulk as well as surface modification of a wide variety of materials and tissues.

This highly localized structuration associated with a very low onset of thermal side-effects constitutes a strong advantage to achieve well-controlled modifications of an irradiated area, especially for the biomedical and biological fields, where high-value applications have been adapted to this relatively new technique.

For that very reason, ultrafast laser-induced surface and bulk functions have frequently been reported on in the literature concerning biocompatible materials and biological tissues/organs, with current hot topic functions such as repellent surfaces, antibacterial and antivirus surface properties, preferential cell growth, cell permeabilization, biological tissue ablation/softening/dissection, etc.

We would like to encourage researchers to showcase their latest research findings through the upcoming Special Issue “Frontiers in Ultrafast Laser Micro- and Nanoprocessing: Biomedical, Biological, and Life Science Applications”, to share their most recent results related to bulk or surface processing with femtosecond and picosecond pulses of biological tissues and/or biocompatible materials with the scope of rendering a local function of interest in the biomedical, biological, and life science domains. Particular interest is devoted to advanced laser beam delivery (to the site of interest) and modifications at the micrometric and/or nanometer level, as these scales are well-adapted for ultrafast laser irradiation.

Dr. Cyril Mauclair
Dr. Xxx Sedao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ultrafast laser interactions with biological media (tissues, cells, organs...)
  • laser-induced surface and bulk biological functions (antibacterial, antiviral, cell growth etc.)
  • organ/scaffold and lab on chip fabrication  (ablation, cutting, polymerisation, etching etc.)
  • ultrafast pulses for biological diagnostics (LIBS, nonlinear imaging etc.)
  • ultrafast NP generation for biological markers
  • cell permeabilization by ultrafast laser pulses
  • laser-assisted cell deposition/printing
  • implant fabrication, structuring and traceability

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Published Papers (2 papers)

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16 pages, 4560 KiB  
Article
Ultrafast Laser Patterning of Metals Commonly Used in Medical Industry: Surface Roughness Control with Energy Gradient Pulse Sequences
by Luca Leggio, Yoan Di Maio, Alina Pascale-Hamri, Gregory Egaud, Stephanie Reynaud, Xxx Sedao and Cyril Mauclair
Micromachines 2023, 14(2), 251; https://doi.org/10.3390/mi14020251 - 19 Jan 2023
Cited by 2 | Viewed by 2303
Abstract
Ultrafast laser ablation is widely used as a versatile method for accurate micro-machining of polymers, glasses and metals for a variety of industrial and biomedical applications. We report on the use of a novel process parameter, the modulation of the laser pulse energy [...] Read more.
Ultrafast laser ablation is widely used as a versatile method for accurate micro-machining of polymers, glasses and metals for a variety of industrial and biomedical applications. We report on the use of a novel process parameter, the modulation of the laser pulse energy during the multi-scan texturing of surfaces. We show that this new and straightforward control method allows us to attain higher and lower roughness (Ra) values than the conventional constant pulse energy irradiation sequence. This new multi-scanning laser ablation strategy was conducted on metals that are commonly used in the biomedical industry, such as stainless steel, titanium, brass and silver samples, using a linear (increasing or decreasing) gradient of pulse energy, i.e., varying the pulse energy across successive laser scans. The effects of ablation were studied in terms of roughness, developed interfacial area ratio, skewness and ablation efficiency of the processed surfaces. Significantly, the investigation has shown a global trend for all samples that the roughness is minimum when a decreasing energy pulse sequence is employed, i.e., the irradiation sequence ends up with the applied laser fluences close to threshold laser fluences and is maximum with increasing energy distribution. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis on single craters with the three different energy deposition conditions revealed a chaotic and random material redistribution in the cases of uniform and increasing energy distributions and the presence of regular laser-induced periodic surface structures (LIPSS) at the bottom of the ablation region in the case of decreasing energy distribution. It is also shown that the ablation efficiency of the ablated surfaces does not significantly change between the three cases. Therefore, this novel energy control strategy permits the control of the roughness of the processed surfaces without losing the ablation efficiency. Full article
(This article belongs to the Special Issue Ultrafast Photonics for Biomedical, Biological and Life Science Applications)
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9 pages, 1851 KiB  
Article
Characterization of Femtosecond Laser and Porcine Crystalline Lens Interactions by Optical Microscopy
by Olfa Ben Moussa, Abderazek Talbi, Sylvain Poinard, Thibaud Garcin, Anne-Sophie Gauthier, Gilles Thuret, Philippe Gain, Aurélien Maurer, Xxx Sedao and Cyril Mauclair
Micromachines 2022, 13(12), 2128; https://doi.org/10.3390/mi13122128 - 1 Dec 2022
Viewed by 1555
Abstract
The use of ultrafast laser pulses for eye anterior segment surgery has seen a tremendous growth of interest as the technique has revolutionized the field, from the treatment of myopia, hyperopia, and presbyopia in the cornea to laser-assisted cataract surgery of the crystalline [...] Read more.
The use of ultrafast laser pulses for eye anterior segment surgery has seen a tremendous growth of interest as the technique has revolutionized the field, from the treatment of myopia, hyperopia, and presbyopia in the cornea to laser-assisted cataract surgery of the crystalline lens. For the latter, a comprehensive understanding of the laser–tissue interaction has yet to be achieved, mainly because of the challenge of observing the interaction zone in situ with sufficient spatial and temporal resolution in the complex and multi-layered tissue of the crystalline lens. We report here on the dedicated characterization results of the laser–tissue interaction zone in the ex vivo porcine lens using three different methods: in situ and real-time microscopy, wide-field optical imaging, and phase-contrast microscopy of the histological cross sections. These complementary approaches together revealed new physical and biological consequences of laser irradiation: a low-energy interaction regime (pulse energy below ~1 µJ) with very limited cavitation effects and a stronger photo-disruption regime (pulse energy above 1 µJ) with a long cavitation duration from seconds to minutes, resulting in elongated spots. These advances in the understanding of the ultrafast laser’s interactions with the lens are of the utmost importance for the preparation of the next-generation treatments that will be applied to the lens. Full article
(This article belongs to the Special Issue Ultrafast Photonics for Biomedical, Biological and Life Science Applications)
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