Fast Bio-Chemical Test

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 August 2022) | Viewed by 5948

Special Issue Editors


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Guest Editor
Department of Mechanical and Industrial Engineering, Concordia University, 1455 de Maisonneuve Blvd. West, Montreal, QC H3G 1M8, Canada
Interests: microsystems; sensing (inertial, flow, load, strain); design of MEMS; data processing; modeling of coupled micro and macro systems; packaging of microsensors; MEMS for turbulence control; microfabrication; non-conventional microfabrication; rapid prototyping; migration from auto to aero; reliability of MEMS; failure models; test methodologies
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Guest Editor
Faculty of Engineering, Autonomous University of Queretaro, San Juan del Rio, Querétaro, Mexico
Interests: MEMS; microfluidics; paper-based systems

Special Issue Information

Dear Colleagues,

Given the present circumstances, the research community is participating in contributing to the detection and monitoring of viruses and bacteria. Efforts in this direction are found everywhere in the world, as all humanity is currently facing the present pandemic. We plan to prepare a Special Issue to gather the efforts of all the researchers who have interests in and have carried out work in fast bio-chemical testing, and could present principles, methods, platforms, or results of their efforts to develop a fast and safe test to detect specific medical conditions including viral infections. Paper-based devices represent a great potential in this search and such works are welcomed, though the treatment of virus-induced diseases is another subject that is not targeted by our Special Issue (although the subject dominates the interests of the applied medical science and the clinicians). However, detection is a subject in which science and technology might make a significant contribution into the development of such practical and extremely necessary platforms. Hence, papers that cover the subject are welcomed from scientists from any area of investigation including biochemistry, engineering, medical sciences, etc.

The main objective of this Special Issue is to gather the multidisciplinary knowledge that could contribute to the development of a fast test for viral assessment that will be of great use in the next pandemic. Any small step forward could make possible a major step forward towards the eradication of such conditions. We shall publicize the results of the findings of the contributors to international and national funding agencies.

Fast testing means a procedure that could be carried out outside a care facility and that could yield a trusty assessment. The principle of detection should be producing consistent results based on detectable bio-chemical reaction, spectral analysis, micro-calorimetric method, colorimetric or other detectable physical or chemical and biological methods. Microfluidic platforms integrated with one of the above principles may represent a potential solution to the problem.

Prof. Dr. Ion Stiharu
Dr. Angel Perez-Cruz
Guest Editors

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Keywords

  • fast tests
  • rapid diagnostics
  • microfluidic platforms
  • paper-based systems
  • bio-chemical reaction
  • viruses and bacteria
  • COVID-19

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Published Papers (2 papers)

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Review

22 pages, 2221 KiB  
Review
Lateral Flow Immunoassays for Detecting Viral Infectious Antigens and Antibodies
by Rowa Y. Alhabbab
Micromachines 2022, 13(11), 1901; https://doi.org/10.3390/mi13111901 - 3 Nov 2022
Cited by 5 | Viewed by 3001
Abstract
Abundant immunological assays currently exist for detecting pathogens and identifying infected individuals, making detection of diseases at early stages integral to preventing their spread, together with the consequent emergence of global health crises. Lateral flow immunoassay (LFIA) is a test characterized by simplicity, [...] Read more.
Abundant immunological assays currently exist for detecting pathogens and identifying infected individuals, making detection of diseases at early stages integral to preventing their spread, together with the consequent emergence of global health crises. Lateral flow immunoassay (LFIA) is a test characterized by simplicity, low cost, and quick results. Furthermore, LFIA testing does not need well-trained individuals or laboratory settings. Therefore, it has been serving as an attractive tool that has been extensively used during the ongoing COVID-19 pandemic. Here, the LFIA strip’s available formats, reporter systems, components, and preparation are discussed. Moreover, this review provides an overview of the current LFIAs in detecting infectious viral antigens and humoral responses to viral infections. Full article
(This article belongs to the Special Issue Fast Bio-Chemical Test)
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10 pages, 977 KiB  
Review
Neuronal Activity Reporters as Drug Screening Platforms
by Igal Sterin, Ana C. Santos and Sungjin Park
Micromachines 2022, 13(9), 1500; https://doi.org/10.3390/mi13091500 - 9 Sep 2022
Viewed by 2187
Abstract
Understanding how neuronal activity changes and detecting such changes in both normal and disease conditions is of fundamental importance to the field of neuroscience. Neuronal activity plays important roles in the formation and function of both synapses and circuits, and dysregulation of these [...] Read more.
Understanding how neuronal activity changes and detecting such changes in both normal and disease conditions is of fundamental importance to the field of neuroscience. Neuronal activity plays important roles in the formation and function of both synapses and circuits, and dysregulation of these processes has been linked to a number of debilitating diseases such as autism, schizophrenia, and epilepsy. Despite advances in our understanding of synapse biology and in how it is altered in disease, the development of therapeutics for these diseases has not advanced apace. Many neuronal activity assays have been developed over the years using a variety of platforms and approaches, but major limitations persist. Current assays, such as fluorescence indicators are not designed to monitor neuronal activity over a long time, they are typically low-throughput or lack sensitivity. These are major barriers to the development of new therapies, as drug screening needs to be both high-throughput to screen through libraries of compounds, and longitudinal to detect any effects that may emerge after continued application of the drug. This review will cover existing assays for measuring neuronal activity and highlight a live-cell assay recently developed. This assay can be performed with easily accessible lab equipment, is both scalable and longitudinal, and can be combined with most other established methods. Full article
(This article belongs to the Special Issue Fast Bio-Chemical Test)
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