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Microorganisms
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An Update on Listeria monocytogenes, Third Edition
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An Update on Listeria monocytogenes, Third Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: 15 February 2025 | Viewed by 2137

Special Issue Editor

Prof. Dr. Elena González-Fandos

E-Mail Website
Guest Editor
Food Technology Department, CIVA Research Center, University of La Rioja, Madre de Dios 53, 26006 Logroño, La Rioja, Spain
Interests: campylobacter; poultry; Listeria; foodborne pathogens
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issues, “An Update on Listeria monocytogenes” and “An Update on Listeria monocytogenes 2.0”.

Listeria monocytogenes causes listeriosis, a disease with a relatively low incidence (2549 reported cases in the European Union in 2018) but with a high mortality rate (15.6%). Listeria monocytogenes is widely distributed in nature, and is resistant to adverse environmental conditions. The control of this pathogen in food-processing facilities is necessary to prevent the contamination of food. Recent large outbreaks (South Africa 2017–2018 and Spain 2019) have resulted in a renewed interest in this pathogen. An update on the epidemiology, prevalence, pathogenicity, antibiotic resistance, biofilm formation, and control of L. monocytogenes is of great interest in order to develop a better understanding of its persistence in the food chain and to establish strategies to reduce human infections.

The objective of this Special Issue of Microorganisms is to present the latest research on various aspects of L. monocytogenes, including prevalence, epidemiology, pathogenicity, antibiotic resistance, biofilm formation, growth and survival in foods, as well as strategies to control this pathogen. Original research and review articles are invited for submission.

Prof. Dr. Elena González-Fandos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Listeria monocytogenes
  • epidemiology
  • pathogenicity
  • antibiotic resistance
  • biofilm formation

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Published Papers (1 paper)

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Research

18 pages, 2690 KiB  
Article
Druggability Analysis of Protein Targets for Drug Discovery to Combat Listeria monocytogenes
by Robert Hanes, Yanhong Liu and Zuyi Huang
Microorganisms 2024, 12(6), 1073; https://doi.org/10.3390/microorganisms12061073 - 25 May 2024
Viewed by 1352
Abstract
Extensive research has been conducted to identify key proteins governing stress responses, virulence, and antimicrobial resistance, as well as to elucidate their interactions within Listeria monocytogenes. While these proteins hold promise as potential targets for novel strategies to control L. monocytogenes, [...] Read more.
Extensive research has been conducted to identify key proteins governing stress responses, virulence, and antimicrobial resistance, as well as to elucidate their interactions within Listeria monocytogenes. While these proteins hold promise as potential targets for novel strategies to control L. monocytogenes, given their critical roles in regulating the pathogen’s metabolism, additional analysis is needed to further assess their druggability—the chance of being effectively bound by small-molecule inhibitors. In this work, 535 binding pockets of 46 protein targets for known drugs (mainly antimicrobials) were first analyzed to extract 13 structural features (e.g., hydrophobicity) in a ligand–protein docking platform called Molsoft ICM Pro. The extracted features were used as inputs to develop a logistic regression model to assess the druggability of protein binding pockets, with a value of one if ligands can bind to the protein pocket. The developed druggability model was then used to evaluate 23 key proteins from L. monocytogenes that have been identified in the literature. The following proteins are predicted to be high-potential druggable targets: GroEL, FliH/FliI complex, FliG, FlhB, FlgL, FlgK, InlA, MogR, and PrfA. These findings serve as an initial point for future research to identify specific compounds that can inhibit druggable target proteins and to design experimental work to confirm their effectiveness as drug targets. Full article
(This article belongs to the Special Issue An Update on Listeria monocytogenes, Third Edition)
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