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Microorganisms
Special Issues
Microbiota in Human Health and Disease
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Microbiota in Human Health and Disease

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 3598

Special Issue Editors

Dr. Claire Morgan

E-Mail Website
Guest Editor
College of Medicine, Institute of Life Science, Swansea University, Swansea SA2 8PP, UK
Interests: cancer
Dr. Paul D. Facey

E-Mail Website
Guest Editor
Biomedical Sciences, Swansea University Medical School, Singleton Park Campus, Swansea SA2 8PP, Wales, UK
Interests: gut microbiome; microbiology; genome evolution
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In this special collection, we extend an invitation to researchers to submit manuscripts falling within the broad scope of "Microbiota in Human Health and Disease". We welcome original research papers that focus on the interplay between microbial communities and their hosts. Review articles and case studies will also be considered. The primary focus of this collection is to showcase studies that not only deepen our understanding of the implications of changes in microbiota composition for disease states but also offer valuable insights into translational applications. Manuscripts exploring avenues for therapeutic and preventive interventions are of particular interest.

Dr. Claire Morgan
Dr. Paul D. Facey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiota
  • probiotics
  • prebiotics
  • synbiotics
  • biotherapeutics
  • probiogenomics
  • health and disease

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

12 pages, 1417 KiB  
Article
Coronal and Root Canal Microbiota in Apical Periodontitis with Different PAI
by Adelaide Teofani, Antonio Libonati, Valeria Unida, Silvia Biocca, Alessandro Desideri and Vincenzo Campanella
Microorganisms 2024, 12(8), 1518; https://doi.org/10.3390/microorganisms12081518 - 24 Jul 2024
Viewed by 809
Abstract
Apical periodontitis is an inflammatory disease triggered by oral pathogens invading necrotic root canals. The aim of this study was to evaluate the coronal and root canal bacterial community profiles in primary endodontic infections with different periapical (PAI) indices in comparison to oral [...] Read more.
Apical periodontitis is an inflammatory disease triggered by oral pathogens invading necrotic root canals. The aim of this study was to evaluate the coronal and root canal bacterial community profiles in primary endodontic infections with different periapical (PAI) indices in comparison to oral mucosa controls. A total of 31 patients with primary apical periodontitis, 14 with PAI-1 and 17 with PAI-3 were recruited. Microbial specimens from mucosa (control samples) and endodontic necrotic tissues were collected in each patient. Microbiota composition was studied through 16S ribosomal RNA gene amplicon sequencing analysis. Overall, 2953 taxa from 168 different genera of 451 various microbial species were retrieved in the controls and PAI-1 and PAI-3 groups. Firmicutes is the predominant phylum in the oral controls (34.5%) and PAI-1 (44.4%) groups, while Bacteroidetes is predominant in PAI-3 (38.6%). The Proteobacteria (21.5%) and Fusobacteria (12.5%) relative abundance is higher in oral controls while that of Synergistetes is higher in the PAI-1 (3.5%) and PAI-3 (2.5%) groups, being almost absent in controls (less than 0.1%). Most of the increased bacterial species found in the PAI groups were strict anaerobes. A diminished microbial diversity was found in apical periodontitis with higher PAI. These samples were also characterized by an increase in bacteria belonging to phyla and genera with an increased anaerobic character. Full article
(This article belongs to the Special Issue Microbiota in Human Health and Disease)
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18 pages, 4546 KiB  
Article
Facial Skin Microbiome Composition and Functional Shift with Aging
by Allison Garlet, Valerie Andre-Frei, Nicolas Del Bene, Hunter James Cameron, Anita Samuga, Vimal Rawat, Philipp Ternes and Sabrina Leoty-Okombi
Microorganisms 2024, 12(5), 1021; https://doi.org/10.3390/microorganisms12051021 - 18 May 2024
Cited by 3 | Viewed by 2284
Abstract
The change in the skin microbiome as individuals age is only partially known. To provide a better understanding of the impact of aging, whole-genome sequencing analysis was performed on facial skin swabs of 100 healthy female Caucasian volunteers grouped by age and wrinkle [...] Read more.
The change in the skin microbiome as individuals age is only partially known. To provide a better understanding of the impact of aging, whole-genome sequencing analysis was performed on facial skin swabs of 100 healthy female Caucasian volunteers grouped by age and wrinkle grade. Volunteers’ metadata were collected through questionnaires and non-invasive biophysical measurements. A simple model and a biological statistical model were used to show the difference in skin microbiota composition between the two age groups. Taxonomic and non-metric multidimensional scaling analysis showed that the skin microbiome was more diverse in the older group (≥55 yo). There was also a significant decrease in Actinobacteria, namely in Cutibacterium acnes, and an increase in Corynebacterium kroppenstedtii. Some Streptococcus and Staphylococcus species belonging to the Firmicutes phylum and species belonging to the Proteobacteria phylum increased. In the 18–35 yo younger group, the microbiome was characterized by a significantly higher proportion of Cutibacterium acnes and Lactobacillus, most strikingly, Lactobacillus crispatus. The functional analysis using GO terms revealed that the young group has a higher significant expression of genes involved in biological and metabolic processes and in innate skin microbiome protection. The better comprehension of age-related impacts observed will later support the investigation of skin microbiome implications in antiaging protection. Full article
(This article belongs to the Special Issue Microbiota in Human Health and Disease)
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