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Microorganisms
Special Issues
Skin Microbiome
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Skin Microbiome

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: 15 April 2025 | Viewed by 1599

Special Issue Editor

Prof. Dr. Zhe-Xue Quan

E-Mail Website
Guest Editor
Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, School of Life Sciences, Fudan University, Shanghai 200438, China
Interests: nitrification; comammox; enrichment; skin microbiome; metatranscriptome

Special Issue Information

Dear Colleagues,

The skin, our largest organ, is the first line of defense against the external environment. Beneath its surface lies a complex and diverse community: the skin microbiome. This network of microorganisms, including bacteria, fungi, viruses, and mites, plays a key role in maintaining skin health and influences conditions ranging from acne to eczema, psoriasis, and even broader systemic diseases. Recent advances in multi-omics and bioinformatics have greatly expanded our understanding of the diversity and functions of skin microbes, altering how we perceive their interactions with the host and the environment.

This Special Issue of Microorganisms gathers cutting-edge research and in-depth reviews that explore the essential components of the skin microbiota, examine host-microbe relationships, and address the possibilities of modifying the skin microbiome for health benefits. With contributions from experts around the globe, this collection seeks to extend current knowledge and encourage a deeper exploration of the skin microbiome’s role in health and disease.

We are excited to present this Special Issue and hope the diverse range of topics will inspire further research and cooperation in this promising field.

Prof. Dr. Zhe-Xue Quan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin health
  • skin microbes
  • multi-omics and bioinformatics
  • host-microbe relationship

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Published Papers (2 papers)

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Research

12 pages, 2179 KiB  
Article
Distinct Intraspecies Variation of Cutibacterium acnes and Staphylococcus epidermidis in Acne Vulgaris and Healthy Skin
by Tina Hamann, Holger Brüggemann, Cecilie Feidenhansl, Erinda Rruci, Julia Gallinger, Stefan Gallinat and Jennifer Hüpeden
Microorganisms 2025, 13(2), 299; https://doi.org/10.3390/microorganisms13020299 - 29 Jan 2025
Viewed by 528
Abstract
Human skin hosts a diverse array of microorganisms that contribute to its health. Key players in the facial skin microbiome include Cutibacterium acnes and staphylococci, whose colonization patterns may influence dermatological conditions like acne vulgaris. This study examined the facial microbiome composition of [...] Read more.
Human skin hosts a diverse array of microorganisms that contribute to its health. Key players in the facial skin microbiome include Cutibacterium acnes and staphylococci, whose colonization patterns may influence dermatological conditions like acne vulgaris. This study examined the facial microbiome composition of 29 individuals, including 14 with moderate to severe acne and 15 with healthy skin, using single locus sequence typing (SLST) amplicon sequencing. The results showed a shift in the relative abundances of C. acnes phylotypes: SLST types A, C, and F were increased in acne, while types H, K, and L were reduced compared to healthy skin. Among staphylococci, the relative abundance of S. epidermidis, S. capitis, and S. saphrophyticus increased in acne, while S. saccharolyticus and S. hominis decreased. The amplicon sequencing approach could also identify a population shift of S. epidermidis: a specific S. epidermidis phylogenetic lineage (type 3) was reduced in acne, while two abundant lineages (types 1 and 2) were elevated. These findings suggest that distinct phylogenetic lineages of both C. acnes and S. epidermidis are linked to healthy versus diseased skin, highlighting a potential role for both microorganisms in disease prevention and aggravation, respectively. Full article
(This article belongs to the Special Issue Skin Microbiome)
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21 pages, 5649 KiB  
Article
Bidirectional Mendelian Randomization Analysis to Study the Relationship Between Human Skin Microbiota and Radiation-Induced Skin Toxicity
by Hui Chen, Xiaojie Xia, Kexin Shi, Tianyi Xie, Xinchen Sun, Zhipeng Xu and Xiaolin Ge
Microorganisms 2025, 13(1), 194; https://doi.org/10.3390/microorganisms13010194 - 17 Jan 2025
Viewed by 592
Abstract
Radiation-induced skin toxicity, resulting from ionizing or nonionizing radiation, is a common skin disorder. However, the underlying relationship between skin microbiota and radiation-induced skin toxicity remains largely unexplored. Herein, we uncover the microbiota–skin interaction based on a genome-wide association study (GWAS) featuring 150 [...] Read more.
Radiation-induced skin toxicity, resulting from ionizing or nonionizing radiation, is a common skin disorder. However, the underlying relationship between skin microbiota and radiation-induced skin toxicity remains largely unexplored. Herein, we uncover the microbiota–skin interaction based on a genome-wide association study (GWAS) featuring 150 skin microbiota and three types of skin microenvironment. Summary datasets of human skin microbiota were extracted from the GWAS catalog database, and summary datasets of radiation-induced skin toxicity from the FinnGen biobank. Mendelian Randomization (MR) analysis was leveraged to sort out the causal link between skin microbiota and radiation-induced skin toxicity. We identified 33 causal connections between human skin microbiota and radiation-induced skin toxicity, including 19 positive and 14 negative causative directions. Among these potential associations, the genus Staphylococcus could serve as a common risk factor for radiation-induced skin toxicity, especially for radiodermatitis. And Streptococcus salivarius was identified as a potential protective factor against radiation-induced skin toxicity. Additional analysis indicated no pleiotropy, heterogeneity, or reverse causal relationship in the results. We comprehensively assessed potential associations of skin microbiota with radiation-induced skin toxicity and identified several suggestive links. Our results provide promising targets for the prevention and treatment of radiation-induced skin toxicity. Full article
(This article belongs to the Special Issue Skin Microbiome)
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