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Bioactive Compounds from Natural Sources: Discovery, Evaluation and Applications, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 808

Special Issue Editors

Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China
Interests: natural product; drug discovery; pharmacology; biochemical engineering; purification; mass spectrometry; fatty acid; collagen
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Guest Editor
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Interests: bioactive molecules; drug design and synthesis; endocannabinoid system modulators; neurodegenerative diseases; anticancer agents; anti-inflammatory activity
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
Interests: medicinal chemistry; drug synthesis; drug discovery; organic synthesis; endocannabinoid system modulators synthesis; polyphenols
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive compounds from natural sources and related structural analogues are attracting particular attention for their possible therapeutic potential and medical applications, especially for cancer, cardiovascular diseases, and infectious diseases. Nevertheless, bioactive compounds from complex matrix sources also present a great challenge to discovery, isolation, characterization, evaluation, and application. Improved isolation techniques, analytical tools, genome mining, engineering strategies, and microbial culturing advances are addressing such challenges and opening up new opportunities. The aim of this Special Issue is to collect important contributions in the field of bioactive compounds from plants, microbes, and animals. It covers research topics, including the following:

  1. The isolation, structural elucidation, synthesis, transformation, and chemical modification of bioactive compounds.
  2. Applications of advanced analytical technologies to bioactive compounds, including NMR, LC-MS, HRMS, IR, microcrystal electron diffraction, metabolomics, the profiling of responses to bioactive molecules at the single-cell level, genome-mining-driven discovery of bioactive compounds and related structural analogues, and the application of advanced microbial culturing approaches to identify new bioactive compounds.
  3. The potential therapeutic applications and mechanisms of natural and natural-derived bioactive compounds based on in vitro or in vivo experiments.

We encourage you to send research and review articles related to aspects relevant to this Special Issue topic. Bioactive evaluations of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.

Dr. Tao Liu
Dr. Clementina Manera
Dr. Francesca Gado
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compound
  • natural product
  • isolation
  • synthesis
  • structural elucidation
  • bioactivity evaluation

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Published Papers (1 paper)

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Research

29 pages, 4917 KiB  
Article
Polyphenolic Compounds in the Stems of Raspberry (Rubus idaeus) Growing Wild and Cultivated
by Ain Raal, Anni Vahtra, Oleh Koshovyi, Tetiana Ilina, Alla Kovalyova and Tõnu Püssa
Molecules 2024, 29(21), 5016; https://doi.org/10.3390/molecules29215016 - 23 Oct 2024
Viewed by 542
Abstract
The stems of Rubus idaeus L., a byproduct of the fruit–food industry, are known sources of bioactive compounds. The main objective of this study was to investigate the composition of polyphenolic compounds in R. idaeus stems. Seven cultivated raspberry varieties, thirteen garden samples, [...] Read more.
The stems of Rubus idaeus L., a byproduct of the fruit–food industry, are known sources of bioactive compounds. The main objective of this study was to investigate the composition of polyphenolic compounds in R. idaeus stems. Seven cultivated raspberry varieties, thirteen garden samples, including five well-known raspberry varieties, and thirteen wild raspberry samples from different locations in Estonia were analyzed. The HPLC-MS method detected 62 substances, of which 42 were identified, 12 were tentatively identified, and 8 compounds remained unknown. Protocatechuic acid pentoside was dominant in most varieties and in all garden and wild raspberry samples. Dihydroxybenzoic acid hexoside 1, p-coumaroyl quinic acid 1, quercetin 4’-glucuronide, and p-coumaric acid glycoside were found in significant quantities. Correlations among the contents of individual compounds were established. When studying the dynamics of polyphenolic compound accumulation in, for example, the GR1 sample over a year, it was found that, in raspberry stems, the largest amount of them accumulated in April and slightly less in January and October. Investigating the dependence of the accumulation of polyphenols on the parts of the stem, it was found that the upper parts have the highest phenolic contents. Therefore, it is recommended to harvest approximately the upper third of the stem. Full article
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