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Cannabinoids in Health and Disease

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 5816

Special Issue Editors


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Guest Editor
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Interests: bioactive molecules; drug design and synthesis; endocannabinoid system modulators; neurodegenerative diseases; anticancer agents; anti-inflammatory activity
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Interests: cannabinoid receptors; orthosteric/allosteric modulators of cannabinoid receptors; antineurodegenerative agents; antitumoral agents; drug design and synthesis

Special Issue Information

Dear Colleagues,

The research in the field of cannabinoids was initially associated with the active principles present in the Cannabis plant, which were identified in the first 70 years of the past century, with the discovery of Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient of the Cannabis plant, in 1964. However, it was the discovery of cannabinoid receptors, their endogenous ligands (endocannabinoids), and enzymes whose discovery occurred in the 1980s–1990s, that provided the basis for further developments in cannabinoid research. Since then, the (patho)physiology of this system has been a very active research area focused on exploring its function in numerous physiological processes in the CNS and its periphery, and, in particular, on elucidating its therapeutic value in numerous disorders.

The purpose of this Special Issue is to publish original research papers, and relevant updates of literature data, on the beneficial effects of cannabinoids in many pathologic conditions, with the aim of highlighting the diversity and innovation of this research field for novel therapeutic applications.

Dr. Clementina Manera
Dr. Simone Bertini
Guest Editors

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Keywords

  • Endocannabinoid system
  • Cannabinoid receptors
  • Endocannabinoids
  • Phytocannabinoids
  • Synthetic cannabinoids

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Published Papers (1 paper)

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Review

26 pages, 6528 KiB  
Review
Cannabinoids and Neurogenesis: The Promised Solution for Neurodegeneration?
by Andrea Valeri and Emanuela Mazzon
Molecules 2021, 26(20), 6313; https://doi.org/10.3390/molecules26206313 - 19 Oct 2021
Cited by 11 | Viewed by 5196
Abstract
The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in the adult brain give hope that some compounds or drugs can enhance this process, helping to reverse the outcomes of diseases or traumas that [...] Read more.
The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in the adult brain give hope that some compounds or drugs can enhance this process, helping to reverse the outcomes of diseases or traumas that once were thought to be everlasting. Cannabinoids, both from natural and artificial origins, already proved to have several beneficial effects (e.g., anti-inflammatory, anti-oxidants and analgesic action), but also capacity to increase neuronal population, by replacing the cells that were lost and/or regenerate a damaged nerve cell. Neurogenesis is a process which is not highly represented in literature as neuroprotection, though it is as important as prevention of nervous system damage, because it can represent a possible solution when neuronal death is already present, such as in neurodegenerative diseases. The aim of this review is to resume the experimental evidence of phyto- and synthetic cannabinoids effects on neurogenesis, both in vitro and in vivo, in order to elucidate if they possess also neurogenetic and neurorepairing properties. Full article
(This article belongs to the Special Issue Cannabinoids in Health and Disease)
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