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Dynamic Nano-Biomaterials for Diverse Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2640

Special Issue Editors


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Guest Editor
Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, India
Interests: antimicrobial resistance (AMR); antibacterial biomaterials; nano-theragnostic materials for AMR and cancer; biomaterials for cancer therapies; functional nanomaterials for biomedical application
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Guest Editor
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Interests: pharmaceutical biotechnology; nanomedicine; nano-biotechnology; drug delivery for cancer applications
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur 603 203, Chennai, Tamil Nadu, India
Interests: oxidative stress; molecular immunology; free radical biology; molecular biology; bioinformatics; peptide biology

Special Issue Information

Dear Colleagues,

Trends in the reactions of dynamic nanomaterials to cell engineering have resulted in innovative tissue remodelling methodologies for better understanding cell regulatory processes and associated applications in recent years. The integration of modern biomaterials-associated systems and methodologies in tissue regeneration approaches in particular enables us to monitor cellular responses during material applications. Furthermore, the tissue-specific milieu that surrounds cells is dynamic as opposed to static. The use of dynamic nanomaterials in tissue remodelling and drug delivery ena-bles diverse biomedical applications by utilising distinct biomaterials and cell-specific modulation capabilities.

Our Special Issue encourages the publication of studies on dynamically designed biomaterials modulating cell fate decision/drug delivery and offers a fresh conceptual approach to regenerative medicine, stem cell treatment, immunomodulation, and cancer therapeutics. Our goal is to provide a suitable platform for innovative biological insights into the function of biomaterials in cell engineering, cell material interactions, extracellular matrix regulation, stem cell biology, novel drug delivery, stimuli-responsive drug delivery, and cancer-targeted delivery treatments. 

This Special Issue welcomes original research and review articles dealing with new concepts relating to the significance of advanced nanomaterials and functional materials platforms for cellular, nano, health, and materials scientists interested in publishing publications on nanoengineering features. Furthermore, this Special Issue will examine the emerging aspects of dynamic biomaterials and their advanced applications, focusing on tissue engineering and drug delivery for their outlook.

Potential topics include, but are not limited to, the following:

  • Dynamic nanomaterials for tissue engineering, disease modeling, drug testing and wound healing applications;
  • Engineering new nanomaterials for regenerative medicine;
  • Challenging approaches to the fabrication and physicochemical/biological response of nanomaterials at the biointerface with cells, tissues, or organs;
  • Nano-based hydrogels for the engineering of 3D cellular microenvironment;
  • Multi-functional nanoparticles for therapy and diagnostics;
  • Advanced strategies of nanotechnology in cancer for systematic diagnosis and therapy;
  • Nanotechnology for better targeting and delivery uniformity for cancer treatment;
  • Novel tools based on nanostructured carriers for cancer patients;
  • Advances in nanostructured materials-based biosensors for cancer detection;
  • Analyzing biomarkers with precision for cancer management.

Prof. Dr. Muthupandian Saravanan
Dr. Hamed Barabadi
Dr. Jesu Arockiaraj
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • tissue engineering
  • cancer therapeutics
  • diagnosis
  • drug delivery
  • regenerative medicine
  • biosensors
  • biomarkers

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Published Papers (1 paper)

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Research

17 pages, 5625 KiB  
Article
Anti-Cancer and Anti-Inflammatory Activities of a Short Molecule, PS14 Derived from the Virulent Cellulose Binding Domain of Aphanomyces invadans, on Human Laryngeal Epithelial Cells and an In Vivo Zebrafish Embryo Model
by Manikandan Velayutham, Purabi Sarkar, Gokul Sudhakaran, Khalid Abdullah Al-Ghanim, Shahid Maboob, Annie Juliet, Ajay Guru, Saravanan Muthupandian and Jesu Arockiaraj
Molecules 2022, 27(21), 7333; https://doi.org/10.3390/molecules27217333 - 28 Oct 2022
Cited by 16 | Viewed by 2175
Abstract
In this study, the anti-cancer and anti-inflammatory activities of PS14, a short peptide derived from the cellulase binding domain of pathogenic fungus, Aphanomyces invadans, have been evaluated, in vitro and in vivo. Bioinformatics analysis of PS14 revealed the physicochemical properties and the [...] Read more.
In this study, the anti-cancer and anti-inflammatory activities of PS14, a short peptide derived from the cellulase binding domain of pathogenic fungus, Aphanomyces invadans, have been evaluated, in vitro and in vivo. Bioinformatics analysis of PS14 revealed the physicochemical properties and the web-based predictions, which indicate that PS14 is non-toxic, and it has the potential to elicit anti-cancer and anti-inflammatory activities. These in silico results were experimentally validated through in vitro (L6 or Hep-2 cells) and in vivo (zebrafish embryo or larvae) models. Experimental results showed that PS14 is non-toxic in L6 cells and the zebrafish embryo, and it elicits an antitumor effect Hep-2 cells and zebrafish embryos. Anticancer activity assays, in terms of MTT, trypan blue and LDH assays, showed a dose-dependent inhibitory effect on cell proliferation. Moreover, in the epithelial cancer cells and zebrafish embryos, the peptide challenge (i) caused significant changes in the cytomorphology and induced apoptosis; (ii) triggered ROS generation; and (iii) showed a significant up-regulation of anti-cancer genes including BAX, Caspase 3, Caspase 9 and down-regulation of Bcl-2, in vitro. The anti-inflammatory activity of PS14 was observed in the cell-free in vitro assays for the inhibition of proteinase and lipoxygenase, and heat-induced hemolysis and hypotonicity-induced hemolysis. Together, this study has identified that PS14 has anti-cancer and anti-inflammatory activities, while being non-toxic, in vitro and in vivo. Future experiments can focus on the clinical or pharmacodynamics aspects of PS14. Full article
(This article belongs to the Special Issue Dynamic Nano-Biomaterials for Diverse Biomedical Applications)
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